Impact of oxidative stress on female fertility

Ruder, Elizabeth H.; Hartman, Terryl J.; Goldman, Marlene B.

doi:10.1097/gco.0b013e32832924ba

Cited by 207 publications

(148 citation statements)

References 43 publications

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“…However, no significant change in malondialdehyde (MDA) concentrations was seen after the consumption of selenium supplements in rats [16]. Beneficial effects of selenium supplementation on improved reproductive outcomes, biomarkers of inflammation, and oxidative stress might be attributed to its inhibitory effect on augmentation of proinflammatory cytokines and reactive oxygen species/reactive nitrogen species [17,18]. Borderline selenium status is high among healthy Iranian women.…”

Section: Affiliationsmentioning

confidence: 99%

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

et al. 2015

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Selenium supplementation could be effective on reproductive outcomes, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS). The aim of the study was to determine the effects of selenium supplementation on reproductive outcomes, biomarkers of inflammation, and oxidative stress in PCOS patients. The present randomized double-blind, placebo-controlled trial was conducted on 64 women aged 18?40 years old with PCOS at the clinic affiliated to Ardabil University of Medical Sciences, Ardabil, Iran. The participants were randomly assigned to 2 groups receiving either 200??g selenium daily (n=32) or placebo (n=32) for 8 weeks. Hormonal profiles, biomarkers of inflammation, and oxidative stress were measured and compared both before and after the treatment. After 8 weeks of intervention, pregnancy rate in the selenium group was higher than in the placebo group: 18.8 (6/32) vs. 3.1% (1/32), p=0.04. In addition, alopecia (40.6 vs. 9.4%, p=0.004) and acne (46.9 vs. 12.5 %, p=0.003) decreased following the consumption of selenium supplements compared with placebo. Additionally, patients who received selenium supplements had significantly decreased serum dehydroepiandrosterone (DHEA) levels (p=0.02), hirsutism (modified Ferriman?Gallwey scores) (p<0.001), serum high sensitivity C-reactive protein (hs-CRP) (p=0.02), and plasma malondialdehyde (MDA) levels (p=0.01) compared with placebo. We did not observe any significant effects of taking selenium supplements on other hormonal profiles, nitric oxide (NO), and other biomarkers of oxidative stress. Taken together, selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels.

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Section: Affiliationsmentioning

confidence: 99%

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

et al. 2015

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“…In addition, oxidative stress and a disrupted antioxidant system are reported to be involved in a variety of pregnancy complications such as preterm labor, fetal growth restriction, preeclampsia and miscarriage Sugino et al, 2007). Numerous studies have also shown that oxidative stress plays a role in the pathophysiology of infertility (Tremellen, 2008;Ruder et al, 2009) and assisted fertility .…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress status of highly prolific sows during gestation and lactation

Berchieri-Ronchi

Kim

Yan

et al. 2011

Animal

159

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Elevated oxidative stress is reported to be associated with pregnancy complications in highly prolific sows. Oxidative DNA damage and the antioxidant status were determined in blood samples collected during the course of gestation and lactation in multiparous sows. Blood samples were drawn from sows (n 5 5) on days 30, 60, 90 and 110 of gestation (G30, G60, G90 and G110, respectively), on day 3, 10 and 18 of lactation (L3, L10 and L18, respectively) and on day 5 of postweaning (W5). Lymphocytes were isolated from the fresh blood and cryopreserved in each time point. Lymphocyte DNA damage was analyzed by alkaline single-cell gel electrophoresis (comet assay) to determine the single-and double-strand brakes and endogenous antioxidant concentrations using an HPLC system with UV detection. The comet assay showed elevated (P , 0.05) DNA damage (between 38% and 47%) throughout the gestational and lactational periods than during early gestation (G30; 21%). Plasma retinol concentration was reduced (P , 0.05) at the end of gestation (G110) compared with G30. Plasma a-tocopherol concentrations also showed a similar trend as to retinol. This study indicates that there is an increased systemic oxidative stress during late gestation and lactation, which are not fully recovered until the weaning compared with the G30, and that antioxidant nutrients in circulation substantially reduced in the mother pig at G110.

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“…Thus, antioxidants promote meiosis-II [108]. The ROS produced by the preovulatory follicle is considered an important inducer of ovulation [109]. Thus, ROS do not always cause adverse effects [110].…”

Section: Relationship Between Progesterone and Oxidative Stress In Rumentioning

confidence: 99%

Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

Kuru¹,

Kükürt²,

Oral³

et al. 2018

Sex Hormones in Neurodegenerative Processes and Diseases

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Studies to determine the physiological effects and functions of progesterone started in the twentieth century. Progesterone is a steroid-structured hormone with 21 carbon atoms originating from cholesterol. The corpus luteum, formed after ovulation in ruminants, secretes progesterone, which plays a role in the continuity of the pregnancy. Progestagens can be used for estrus synchronization in cows and heifers. Similarly, they are used for estrus synchronization during the breeding season or outside the breeding season by taking advantage of the negative feedback effect of progesterone in small ruminants. It is applied for the treatment of embryonic deaths due to luteal insufficiency in cows with high milk yield. In anovulatory anestrus, exogenous progesterone applications can be very useful. Progesterone treatment contributes to the resolution of the anestrus by rearranging hypothalamic functions in cattle with follicular cysts. The oxidative stress index in the luteal phase, when progesterone is high in ruminants, is higher than in the follicular phase. In the critical period of pregnancy, a high index of oxidative stress-induced progesterone causes embryonic death. Factors that cause stress in high milk-yielding cows can affect the amount of progesterone synthesis by inhibiting luteal cell function due to excessive free radical production.

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Impact of oxidative stress on female fertility

Cited by 207 publications

References 43 publications

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome

Oxidative stress status of highly prolific sows during gestation and lactation

Clinical Use of Progesterone and Its Relation to Oxidative Stress in Ruminants

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