Impact of oligon central venous catheters on catheter colonization and catheter-related bloodstream infection

Ranucci, Marco; Isgrò, Giuseppe; Giomarelli, P.; Pavesi, Marco; Luzzani, Aldo; Cattabriga, Iolter; Carli, Manuela; Giomi, Paolo; Compostella, Antonio; Digito, A; Mangani, Valerio; Silvestri, Vito N.; Mondelli, Enzo

doi:10.1097/00003246-200301000-00008

Cited by 85 publications

(38 citation statements)

References 30 publications

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“…By July 2005 a further 11 trials had been published. [8][9][10][11][12][13][14][15][16][17][18] This review was commissioned to determine the clinical effectiveness and cost-effectiveness of CVCs treated with anti-infective agents (AI-CVCs).…”

Section: Introductionmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

Hockenhull¹,

Dwan²,

Boland³

et al. 2008

Health Technol Assess

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Section: Introductionmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

Hockenhull¹,

Dwan²,

Boland³

et al. 2008

Health Technol Assess

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Section: Discussionmentioning

confidence: 99%

“…In prospective randomized clinical trails, the Oligon Vantex CVCs (SPC-CVCs) significantly reduced the incidence of catheter colonization (7,36). However, the study by Ranucci et al lacked the power to detect differences in rates of catheterrelated bloodstream infection (36). Another recent prospective, randomized, controlled multicenter clinical trial showed that the Oligon Vantex CVCs failed to prevent CR-BSI and catheter colonization (24).…”

Section: Discussionmentioning

confidence: 99%

Comparative In Vitro Efficacies and Antimicrobial Durabilities of Novel Antimicrobial Central Venous Catheters

Hanna

Bahna

Reitzel

et al. 2006

Antimicrob Agents Chemother

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We investigated the efficacies and durability of novel antimicrobial central venous catheters (CVCs) in preventing the adherence of microbial organisms to the surfaces of the CVCs. Novel antimicrobial CVCs investigated in this in vitro study were impregnated with antibiotics (minocycline and rifampin), with Oligon agent (silver, platinum, and carbon black), with approved antiseptics (chlorhexidine and silver sulfadiazine), or with a novel antiseptic agent, gendine, which contains gentian violet and chlorhexidine. When tested against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, gendine-coated CVC segments provided protection against bacterial adherence significantly more than all other types of tested CVCs (P < 0.05). Gendine-coated CVCs also provided better protection against Candida albicans and Candida parapsilosis than CVCs impregnated with antibiotics or with silver, platinum, and carbon (P < 0.02). After 28 days of being soaked in serum, the CVCs impregnated with chlorhexidine and silver sulfadiazine and the CVCs impregnated with silver, platinum, and carbon had lost antimicrobial activity against MRSA, P. aeruginosa, and C. parapsilosis, and the CVCs impregnated with minocycline and rifampin had lost activity against P. aeruginosa and C. parapsilosis. The CVCs impregnated with gendine maintained antimicrobial activities against MRSA, P. aeruginosa, and C. parapsilosis after 28 days of being soaked in serum. Central venous catheters impregnated with the novel investigational antiseptic gendine showed in vitro efficacy and provided protection against bacterial adherence more than other approved novel antimicrobial-coated CVCs.

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“…After one hour of interaction, all systems yielded 100% of death. Antimicrobial silver particles alone or in combination with other metals or elements, such as carbon or platinum (Ranucci et al, 2003) or copper (Mclean et al, 1993) were also used to impregnate biomaterials (Davenas et al, 2002). Thin polymeric films prepared by the LbL method assembled oppositely charged polyelectrolytes, loaded with silver nanoparticles and presented differential cytotoxicity representing a good approach to manage microbial burden in wounds without impairment of wound healing (Agarwal et al, 2010).…”

Section: B Amentioning

confidence: 99%

“…Silver has also been extensively used for the development of infection-resistant catheters. Polyurethane catheters in which carbon, silver and platinum particles are incorporated led to an electrochemically driven release of silver ions in the outer and inner vicinities of the catheter surface, demonstrating low catheter-related bloodstream infections (Ranucci et al, 2003). Silver-containing zeolite compounds received approval of Food and Drug Administration (FDA) for being used as food contact surfaces (Joerger, 2007).…”

Section: B Amentioning

confidence: 99%

Antimicrobial Biomimetics

María¹,

Barbassa²,

Melo³

2011

Biomimetic Based Applications

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Impact of oligon central venous catheters on catheter colonization and catheter-related bloodstream infection

Abstract: Oligon treatment is effective in limiting the catheter colonization rate. Due to the limited amount of events, this study lacked the power to detect significant differences in terms of catheter-related bloodstream infection rate.

Cited by 85 publications

References 30 publications

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

Comparative In Vitro Efficacies and Antimicrobial Durabilities of Novel Antimicrobial Central Venous Catheters

Antimicrobial Biomimetics

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