Impact of obesity on autoimmune arthritis and its cardiovascular complications

Raemdonck, Katrien Van; Umar, Sadiq; Szekanecz, Zoltán; Zomorrodi, Ryan K; Shahrara, Shiva

doi:10.1016/j.autrev.2018.02.007

Cited by 49 publications

(33 citation statements)

References 272 publications

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“…Similar studies have shown no definitive correlations in patients with systemic sclerosis [36]. HLADR4, DRβ1, protein tyrosine phosphatase 22, and peptidyl arginine deiminase 4 (PADI4) are among the genes identified with an association for an increased susceptibility in patients with RA [37]. One recent study also suggests an association with PADI4 gene polymorphisms and patients with SLE with additional PADI4 polymorphisms conferring an increased risk of renal involvement in the form of lupus nephritis [38].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Disease-Associated Hypertension

Wolf

Ryan

2019

Curr Hypertens Rep

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Purpose of Review To highlight important new findings on the topic of autoimmune disease-associated hypertension. Recent Findings Autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis are associated with an increased risk for hypertension and cardiovascular disease. A complex interaction among genetic, environmental, hormonal, and metabolic factors contribute to autoimmune disease susceptibility while promoting chronic inflammation that can lead to alterations in blood pressure. Recent studies emphasize an important mechanistic role for autoantibodies in autoimmune disease-associated hypertension. Moving forward, understanding how sex hormones, neutrophils, and mitochondrial dysfunction contribute to hypertension in autoimmune disease will be important. Summary This review examines the prevalent hypertension in autoimmune disease with a focus on the impact of immune system dysfunction on vascular dysfunction and renal hemodynamics as primary mediators with oxidative stress as a main contributor.

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Section: Introductionmentioning

confidence: 99%

Autoimmune Disease-Associated Hypertension

Wolf

Ryan

2019

Curr Hypertens Rep

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“…Obesity is caused by energy input exceeding energy output over a prolonged period. Obesity leads to many health problems, including hypertension (Jayedi et al, 2018), hyperlipidemia (Klop et al, 2013), diabetes mellitus (Caspard et al, 2018), cardiovascular disease (Kotsis et al, 2018), arthritis (Van Raemdonck et al, 2018), atherosclerosis (Lovren et al, 2015), and cancer (Ottaiano et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial

Park

Choi

Ha³

et al. 2019

Food Sci Biotechnol

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Steamed ginger ethanolic extract (SGE) is a product with a high 6-shogaol contents and is thought to be more potent than other ginger products. We conducted a 12-week, randomized, double-blind, placebo-controlled clinical trial to determine the effects of SGE on weight and body fat loss. Eighty healthy obese participants were recruited and randomly divided into the SGE and placebo groups. The outcome measures comprised indicators of efficacy (body weight, body mass index, body composition, and blood markers) and safety. Following the supplementation period, mean body weight, body mass index, and body fat level were significantly lower in the SGE group than in the placebo group. No clinically significant changes were observed for any safety parameter. These results suggest that SGE is a potent anti-obesity agent that does not cause significant side effects. Therefore, SGE supplementation combined with lifestyle modification could be effective in the management of body weight and fat mass.

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“…These sets may be useful in future studies that aim to explain the overlap of obesity, autoimmune disease and cardiovascular disease. [20][21][22] The green module genes were overrepresented in all three types of disease, were strongly associated as a set with TNFa, and were nearly all up-regulated by TNFa, while PLOS ONE the cyan module genes were overrepresented in metabolic and cardiovascular disease but not autoimmune disease, were not associated as a set with TNFa, and were mostly not up-regulated by TNFa. It is therefore possible that it is the green module genes, and not the cyan module genes, that are driving the overlap among these disease types, but further investigation is needed.…”

Section: Plos Onementioning

confidence: 99%

Global expression and CpG methylation analysis of primary endothelial cells before and after TNFa stimulation reveals gene modules enriched in inflammatory and infectious diseases and associated DMRs

et al. 2020

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Endothelial cells are a primary site of leukocyte recruitment during inflammation. An increase in tumor necrosis factor-alpha (TNFa) levels as a result of infection or some autoimmune diseases can trigger this process. Several autoimmune diseases are now treated with TNFa inhibitors. However, genomic alterations that occur as a result of TNF-mediated inflammation are not well understood. To investigate molecular targets and networks resulting from increased TNFa, we measured DNA methylation and gene expression in 40 human umbilical vein endothelial cell primary cell lines before and 24 hours after stimulation with TNFa via microarray. Weighted gene co-expression network analysis identified 15 gene groups (modules) with similar expression correlation patterns; four modules showed a strong association with TNFa treatment. Genes in the top TNFa-associated module were all up-regulated, had the highest proportion of hypomethylated regions, and were associated with 136 Disease Ontology terms, including autoimmune/inflammatory, infectious and cardiovascular diseases, and cancers. They included chemokines CXCL1, CXCL10 and CXCL8, and genes associated with autoimmune diseases including HLA-C, DDX58, IL4, NFKBIA and TNFAIP3. Cardiovascular and metabolic disease genes, including APOC1, ACLY, ELOVL6, FASN and SCD, were overrepresented in a module that was not associated with TNFa treatment. Of 223 hypomethylated regions identified, several were in promoters of autoimmune disease GWAS loci (ARID5B, CD69, HDAC9, IL7R, TNIP1 and TRAF1). Results reveal specific gene groups acting in concert in endothelial cells, delineate those driven by TNFa, and establish their relationship to DNA methylation changes, which has strong implications for understanding disease etiology and precision medicine approaches.

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Impact of obesity on autoimmune arthritis and its cardiovascular complications

Cited by 49 publications

References 272 publications

Autoimmune Disease-Associated Hypertension

Autoimmune Disease-Associated Hypertension

The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial

Global expression and CpG methylation analysis of primary endothelial cells before and after TNFa stimulation reveals gene modules enriched in inflammatory and infectious diseases and associated DMRs

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