Impact of nocturia on patients' health‐related quality of life and healthcare resource utilisation compared with OAB and BPH: Results from an observational survey in European and American patients

Abstract

Objective To evaluate the impact of nocturia on patients' quality of life and healthcare resource utilisation (HRU) compared with overactive bladder (OAB) and benign prostatic hyperplasia (BPH). Methods Data were drawn from a multinational (France, Germany, Spain, UK and US) survey of physician and patient‐reported outcomes. The patient groups of interests were those diagnosed with only nocturia, with only OAB, and with only BPH. Health‐related quality of life (HRQoL) and productivity measures were derived from the EuroQoL‐5D, OAB‐q and the Work Productivity and Activity Impairment Questionnaire (WPAI). Measures of HRU included lower urinary tract symptoms (LUTS)‐relevant surgeries, hospitalisations, current use of pads and related physician visits. Bivariate and multivariate regression analyses were used to evaluate associations between HRQoL/HRU/Productivity and nocturia status. Multivariate analysis was used to address any potential confounding factors among the groups, ie age, gender, body mass index (BMI), ethnicity and comorbidities. Results A total of 3552 patients were identified including 358 nocturia patients, 1415 OAB patients and 1779 BPH patients. The mean age of the nocturia patients was 61.2 years with a mean BMI of 27.3. About 60.6% were women, 87.2% were Caucasian, and their most common comorbidities included depression, hypertension and diabetes. In terms of impact, nocturia patients were significantly worse off than OAB patients in their HRQoL. There was no significant difference regarding HRU and productivity measurement. Nocturia patients also presented with significantly worse HRQoL and lower productivity compared with BPH patients. Nocturia patients also had more physician visits. Conclusions Nocturia should be emphasised as a standalone LUTS disease with substantial patient impact. Compared with OAB and/or BPH, nocturia patients presented with a significant reduction on patients' quality of life, reduced work productivity and increased utilisation of healthcare resources.

Nocturia and effect on the quality of life. A study at Ramathibodi Hospital

“…19 Zeng et al reported that nocturia patients presented as having a significantly reduced quality of life, reduced work productivity and increased utilization of healthcare resources when compared with OAB and/or BPH. 20 Theerawirojana et al reported a correlation between bladder capacity and lower urinary tract symptoms after renal transplantation and concluded that nocturia and nocturnal polyuria are characteristics of lower urinary tract function after renal transplantation, and are probably associated with long term anuria during hemodialysis and small bladder capacity. Quality of life was not impacted by lower urinary tract symptoms evidenced by a low symptom score for most patients.…”

Psychometric validation and interpretation of the Nocturia Impact Diary in a clinical trial setting

“…Although nocturia can have multiple causes, the most common is nocturnal polyuria-overproduction of urine at night [4]. Lifestyle modifications are the first intervention for the management of nocturia but as symptoms progress, such measures may be inadequate, and pharmacotherapy warranted [3,[5][6][7][8][9][10]. Nocturia has a pronounced negative impact on patient QoL [8,[11][12][13] and is associated with reduced work productivity, more frequent physician visits, socioeconomic burden [5,6,10,12,14], sleep impairment [15,16], higher risk of falls and fractures, depression, and increased mortality [3,17,18].…”

“…Lifestyle modifications are the first intervention for the management of nocturia but as symptoms progress, such measures may be inadequate, and pharmacotherapy warranted [3,[5][6][7][8][9][10]. Nocturia has a pronounced negative impact on patient QoL [8,[11][12][13] and is associated with reduced work productivity, more frequent physician visits, socioeconomic burden [5,6,10,12,14], sleep impairment [15,16], higher risk of falls and fractures, depression, and increased mortality [3,17,18]. There has, however, been an unmet need for a validated, reliable, and specific patient-reported instrument to assess the impact of nocturia on patient QoL.…”

Achieving clinically meaningful quality of life benefits in nocturia takes time: Results from a long‐term, multicenter phase 3 study of desmopressin in Japanese patients

“…Nocturnal polyuria, recently defined as excessive production of urine during an individual's main sleep period and previously defined as overproduction of urine at night (>20%‐33% of total 24‐hour urine volume, depending on age), 1 is a frequent contributor to and is present in most patients with nocturia 3 . Nocturia negatively affects quality of life (QoL), 5‐7 with greater QoL effects seen with increasing frequency of nocturnal voids 6,8,9 . The impact on QoL is often due to sleep disruption caused by frequently waking at night to void, with associations seen between nocturia and subjective and objective sleep quality 3,9,10 .…”

“…most patients with nocturia. 3 Nocturia negatively affects quality of life (QoL), [5][6][7] with greater QoL effects seen with increasing frequency of nocturnal voids. 6,8,9 The impact on QoL is often due to sleep disruption caused by frequently waking at night to void, with associations seen between nocturia and subjective and objective sleep quality.…”