Impact of mucus and biofilm on antimicrobial photodynamic therapy: Evaluation using Ruthenium(II) complexes

Photodynamic Eradication of Pseudomonas aeruginosa with Ru-Photosensitizers Encapsulated in Enzyme Degradable Nanocarriers

“…The mechanisms for this improvement via the nanocarrier require further investigation. One may hypothesize that, apart from stabilizing the PS itself, the nanocarriers may affect the interaction of RuPhen3 with the bacterial cell wall, which depends both on the bacterial pathogen and its wall structure (Gram-positive or Gram-negative) and the surrounding media [ 27 , 36 ].…”

“…Corresponding PLA block copolymers have been previously reported for the encapsulation of signaling molecules and their triggered release in the presence of, e.g., the model enzyme proteinase K [ 33 , 34 ]. In this current study, this strategy was adapted and applied to the encapsulation of a potent Ru-based photosensitizer that was reported to show an aPDT effect against planktonic cultures of Pseudomonas aeruginosa and Staphylococcus aureus strains [ 12 , 35 , 36 ]. In particular, the effectiveness of aPDT against Pseudomonas aeruginosa was studied for PEG 114 - block -PLA x micelles and vesicles (polymersomes).…”

2‐Thiophenyl–Isoquinoline Ir(III) Complex: A Promising Tool in Antipseudomonal Photodynamic Therapy under Red Irradiation

“…More interestingly, depending on the nature of the metal and organic moieties, some complexes can be activated with light to generate reactive oxygen species (ROS), and could therefore be employed as photosensitizers (PS) in antibacterial photodynamic therapy (PDT). [11][12][13][14][15][16][17][18] In this booming field, ruthenium complexes have been particularly investigated for their light-promoted antibacterial activity. [11][12][13][14] Other metallic complexes were evaluated more scarcely.…”

“…[11][12][13][14][15][16][17][18] In this booming field, ruthenium complexes have been particularly investigated for their light-promoted antibacterial activity. [11][12][13][14] Other metallic complexes were evaluated more scarcely. As potential antibacterials, iridium complexes offer interesting properties, [15][16][17][18] such as a good photostability and a compatible redox potential at excited state for ROS generation during the irradiation time.…”

“…Absorption maxima and molar absorption coefficient in parenthesis in dichloromethane solution. [b] In deaerated dichloromethane solution c = 1.10 -5 M using an excitation wavelength of 310 nm (5 et 6) or 450 nm(7)(8)(9)(10)(11)(12).…”