Impact of mind–body intervention on proinflammatory cytokines interleukin 6 and 1β: A three-arm randomized controlled trial for persons with sleep disturbance and depression

Ng, Siu-Man; Yin, Margaret Xi Can; Chan, Joanna; Chan, Celia H. Y.; Fong, Ted C. T.; Li, Ang; So, Kwok‐Fai; Yuen, Lai-Ping; Chen, Jianping; Chung, Ka-Fai

doi:10.1016/j.bbi.2021.09.022

Cited by 10 publications

(13 citation statements)

References 59 publications

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“…Our findings on the dose-response are consistent with the previous meta-analysis reporting that improvements in sleep quality were greater when the intervention’s frequency, duration, and total duration were achieved [ 10 ]. Several studies have shown that only MBM intervention longer than three months leads to significant improvements in metabolic profiles [ 101 , 102 ], proinflammatory cytokine [ 103 ], and mental health [ 104 , 105 , 106 ]. Furthermore, the inverted U-shaped hypothesis proposes that moderate-intensity exercise has the most significant cognitive benefits [ 107 , 108 ].…”

Section: Discussionmentioning

confidence: 99%

“…In turn, 74% of patients with anxiety disorders reported sleep disturbances [ 112 ]. Although the exact cause and effect between emotional disorders and poor sleep quality remain unknown, it has been shown that MBM has the potential to effectively treat both major depressive disorder [ 113 , 114 , 115 ] and sleep problems [ 81 , 103 ]. The alleviated negative moods often accompany improved sleep quality after practicing MBM [ 81 , 116 , 117 ].…”

Section: Discussionmentioning

confidence: 99%

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Mindfulness-Based Movement Intervention to Improve Sleep Quality: A Meta-Analysis and Moderator Analysis of Randomized Clinical Trials

Yang

Du²,

Shen

et al. 2022

IJERPH

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(1) Background: Given that the most effective dose, optimal type, and most beneficial population for improving sleep with mindfulness-based movement (MBM) remains unknown, we conducted a systematic review and meta-analysis with moderator analysis of randomized controlled trials (RCTs) to assess these effects. (2) Methods: Three electronic databases (PubMed, Web of Science, and EBSCO) were systematically searched for RCTs published through August 2021 for analysis. The risk of bias of the included studies was assessed with Review Manager 5.3, and the meta-analysis was performed in Stata 16.0. (3) Results: A meta-analysis of 61 RCTs with 2697 participants showed that MBM significantly improved sleep quality compared to controls (SMD = −0.794; 95% CI: −0.794 to −0.994, p < 0.001, I2 = 90.7%). Moderator analysis showed that a long-term MBM (SMD = −0.829; 95% CI: 0.945 to 0.712; p < 0.001) had a larger effect size on sleep than a short-term MBM (SMD = −0.714; 95% CI: 0.784 to 0.644; p < 0.001). Practicing at least twice per week (SMD = −0.793; 95% CI: −0.868 to −0.718; p < 0.001) was more effective compared to practicing once per week (SMD = −0.687; 95% CI: −0.804 to −0.570; p < 0.001). Studies with a total intervention time of more than 24 h also revealed better sleep quality improvement (SMD = −0.759; 95% CI: −0.865 to −0.653; p < 0.001). In addition, the healthy population and older adults gained more from MBM than the patients and younger adults. (4) Conclusions: MBM can effectively improve subjective sleep quality, and the optimal intervention dose of MBM can be utilized in future intervention studies to treat or improve sleep disturbance. (MBM more than twice a week for more than three months, with a total intervention time of more than 24 h).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mindfulness-Based Movement Intervention to Improve Sleep Quality: A Meta-Analysis and Moderator Analysis of Randomized Clinical Trials

Yang

Du²,

Shen

et al. 2022

IJERPH

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“…As introduced in our previous article on the RCT (Ng et al, 2022), the IBMS and Qigong programs were offered twice, respectively, to around 50 participants per intervention in an activity hall, both aiming to promote people's physical, emotional, cognitive, and spiritual wellbeing. They were delivered between 2013 and 2014 under the same schedule with eight weekly 3-hour sessions (i.e., 24 contact hours in total) through initial short lectures and demonstrations, followed by practice and discussion in small groups of 10 to 12.…”

Section: Interventionsmentioning

confidence: 99%

Who Benefits More From IBMS or Qigong? Clinical Data-Mining RCT Data

Fung

Yin

et al. 2023

Research on Social Work Practice

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Purpose: A recent three-arm randomized controlled trial (RCT) with depressed Hong Kong adults demonstrated the comparable effectiveness of integrative Body-Mind-Spirt (IBMS) and Qigong interventions in relieving sleep disturbance and depression, but not which is best for whom? Guided by concept and theory-based hypotheses, clinical data-mining (CDM), the RCT data answers the more clinically relevant question: who responds best to which intervention? Method: Paired-sample t-tests and Wilcoxon signed-ranked tests were adopted to compare the within-subgroup differences; linear mixed models for normally distributed outcomes and generalized linear mixed models for non-normally distributed outcomes were used to compare the between-subgroup differences. Results: Results indicate that IBMS is more efficacious for older, more educated females, suffering from physical pain and illness; whereas younger, less educated males, not in full-time employment benefit more from Qigong. Discussion: This productive joining together of RCT and CDM recommends itself to both past and future RCTs, further informing evidence-based practice decision making.

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“…Not nearly as elegant or as difficult to execute as Ng et al’s (2022) RCT, but relying on the same inherent experimental logic, Herman’s study made use of available agency data routinely collected from depressed and anxiety clients who all received a standardized model of group cognitive behavior therapy (GCBT). The choice of group intervention was both evidence-based and more economical than individual CBT.…”

mentioning

confidence: 99%

“…In fact, I was so impressed by the RCT itself that I nominated him and the paper for a Social Sciences Outstanding Research Award at The University of Hong Kong. Ng et al's (2022) exquisitely executed and arduously implemented, waitlist-controlled study began with screening over 1000 depressed Hong Kong adults and winnowed down to 281 who were eligible, then randomized for study purposes. Ultimately, no one was denied intervention which was either an Integrative Body-Mind-Spirit (IBMS) protocol or a series of Qigong treatments.…”

mentioning

confidence: 99%

One Last Fandango Professor Por Favor? The Potential Contribution of Clinical Data-Mining to Randomized Clinical Trials

Epstein

2022

Research on Social Work Practice

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Impact of mind–body intervention on proinflammatory cytokines interleukin 6 and 1β: A three-arm randomized controlled trial for persons with sleep disturbance and depression

Cited by 10 publications

References 59 publications

Mindfulness-Based Movement Intervention to Improve Sleep Quality: A Meta-Analysis and Moderator Analysis of Randomized Clinical Trials

Mindfulness-Based Movement Intervention to Improve Sleep Quality: A Meta-Analysis and Moderator Analysis of Randomized Clinical Trials

Who Benefits More From IBMS or Qigong? Clinical Data-Mining RCT Data

One Last Fandango Professor Por Favor? The Potential Contribution of Clinical Data-Mining to Randomized Clinical Trials

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