Impact of Macrocephaly, as an Isolated Trait, on EEG Signal as Measured by Spectral Power and Multiscale Entropy during the First Year of Life

López-Arango, Gabriela; Deguire, Florence; Agbogba, Kristian; Audet-Duchesne, Élisabeth; Boucher, Marc-Antoine; Knoth, Inga S; El-Jalbout, Ramy; Damphousse, Amélie; Kadoury, Samuel; Lippé, Sarah

doi:10.1159/000529722

Cited by 1 publication

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“…On the other hand, few to no literature exists regarding exact time intervals of brain activity. The results found here and in our previous publications 40 , 43 , 61 , 62 show theta and alpha activity after a post-stimulus delay, and beta activity early after stimuli onset. Thus, for selecting time intervals, ITC maps were created for each stimulus and testing time point (visit 1 and visit 2) to assess the time–frequency windows (TFW) in which EEG activity showed greater variation in synchronization across trials and testing time points.…”

Section: Methodssupporting

confidence: 89%

EEG repetition and change detection responses in infancy predict adaptive functioning in preschool age: a longitudinal study

Deguire

López-Arango

Knoth

et al. 2023

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Neurodevelopmental disorders (NDDs) are mostly diagnosed around the age of 4–5 years, which is too late considering that the brain is most susceptive to interventions during the first two years of life. Currently, diagnosis of NDDs is based on observed behaviors and symptoms, but identification of objective biomarkers would allow for earlier screening. In this longitudinal study, we investigated the relationship between repetition and change detection responses measured using an EEG oddball task during the first year of life and at two years of age, and cognitive abilities and adaptive functioning during preschool years (4 years old). Identification of early biomarkers is challenging given that there is a lot of variability in developmental courses among young infants. Therefore, the second aim of this study is to assess whether brain growth is a factor of interindividual variability that influences repetition and change detection responses. To obtain variability in brain growth beyond the normative range, infants with macrocephaly were included in our sample. Thus, 43 normocephalic children and 20 macrocephalic children were tested. Cognitive abilities at preschool age were assessed with the WPPSI-IV and adaptive functioning was measured with the ABAS-II. Time–frequency analyses were conducted on the EEG data. Results indicated that repetition and change detection responses in the first year of life predict adaptive functioning at 4 years of age, independently of head circumference. Moreover, our findings suggested that brain growth explains variability in neural responses mostly in the first years of life, so that macrocephalic children did not display repetition suppression responses, while normocephalic children did. This longitudinal study demonstrates that the first year of life is an important period for the early screening of children at risk of developing NDDs.

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