Impact of kidney function and urinary protein excretion on pulmonary function in Japanese patients with chronic kidney disease

Nakade, Yusuke; Toyama, Tadashi; Furuichi, Kengo; Kitajima, Shinji; Ohkura, Noriyuki; Sagara, Akihiro; Shinozaki, Yukiko; Hara, Akinori; Kitagawa, Kiyoki; Shimizu, Miho; Iwata, Yasunori; Oe, Hiroyasu; Nagahara, M; Horita, Hiroshi; Sakai, Yoshio; Kaneko, Shuichi; Wada, Takashi

doi:10.1007/s10157-013-0920-7

Cited by 6 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, it is also an independent risk factor of cardiovascular events and mortality [ 8 ]. Although previous studies have identified a relationship between pulmonary function and UACR as well as chronic kidney disease with reduced estimated glomerular filtration rate (eGFR) [ 9 – 11 ], few studies focus on the T2DM patients with preserved eGFR. As we know, those with T2DM are more likely to have albuminuria and at a higher risk for cardiovascular disease even with preserved eGFR [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between pulmonary function and albuminuria in type 2 diabetic patients with preserved renal function

Chen

Fang

et al. 2020

BMC Endocr Disord

View full text Add to dashboard Cite

Background: Albuminuria is the early manifestation of the pathogenesis of diabetic nephropathy (DN). The current study was to investigate the relationship of pulmonary function with albuminuria in type 2 diabetic patients with preserved renal function to evaluate the role of pulmonary function in the early stage of DN. Methods: A total of 326 patients with type 2 diabetes mellitus (T2DM) including 270 without albuminuria and 56 with albuminuria, and 265 non-diabetic patients were enrolled. The patients' general information, and the parameters of pulmonary function, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, total lung capacity (TLC), diffusion capacity for carbon monoxide of lung (DLCO) were compared between T2DM and control groups, as well as T2DM patients with and without albuminuria groups. All pulmonary function parameters were expressed as a percentage of those predicted (%pred). Logistic regression models were constructed to test the association of albuminuria and pulmonary function. Results: The values of FVC%pred, FEV1%pred, TLC%pred and DLCO%pred were lower, and the proportion of subjects with FVC%pred < 80, FEV1%pred < 80, and DLCOc%pred < 80 was higher in T2DM subjects than controls (all P < 0.05). Subgroup analysis of diabetic patients showed that the values of FVC%pred, FEV1%pred, TLC%pred, and DLCOc%pred (97.18 ± 13.45, 93.95 ± 14.51, 90.64 ± 9.97, 87.27 ± 13.13, respectively) were significantly lower in T2DM subjects with albuminuria than those without albuminuria (103.94 ± 14.12, 99.20 ± 14.25, 93.79 ± 10.36, 92.62 ± 13.45, all P < 0.05). There was a significantly negative correlation between the urine albumin-to-creatinine ratio (UACR) and DLCOc%pred (r = − 0.143, P = 0.010) in spearman linear correlation test. In logistic regression analysis, the FVC%pred (OR 0.965, 95%CI 0.944-0.988), FEV1%pred (OR 0.975, 95%CI 0.954-0.996), and DLCOc%pred (OR 0.974, 95%CI 0.951-0.998) were independently associated with albuminuria after adjustments for smoking index, duration, HbA1c, FBG, and TG. Conclusion: Our results demonstrated albuminuria is associated with a restrictive pulmonary function as well as pulmonary diffusion function in T2DM with preserved renal function, which remind us to be alert of the pulmonary function decline even in the early stage of DN.

show abstract

Section: Introductionmentioning

confidence: 99%

Relationship between pulmonary function and albuminuria in type 2 diabetic patients with preserved renal function

Chen

Fang

et al. 2020

BMC Endocr Disord

View full text Add to dashboard Cite

show abstract

“…A small Japanese study also reported that reduced GFR is associated with reduced pulmonary diffusing capacity 17 . In another retrospective longitudinal analysis, an increased risk of chronic kidney disease was associated with decreased airflow as measured by the FEV1/FVC ratio 18 .…”

Section: Discussionmentioning

confidence: 98%

“…Yu et al [ 16 ] found that in a cohort comprising 1454 Australian and 5824 Chinese individuals, an increased risk of reduced renal function was related to obstructive lung function, and that FEV1 and FVC < 3.05 L increased the risk of impaired renal function. A small Japanese study also reported that reduced GFR is associated with reduced pulmonary diffusing capacity [ 17 ]. In another retrospective longitudinal analysis, an increased risk of chronic kidney disease was associated with decreased airflow as measured by the FEV1/FVC ratio [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Association between serum creatinine levels and pulmonary function of Korean adults: the 2016-2019 Korea National Health and Nutrition Examination Survey

Yeun¹,

Kwak²,

Kim³

2023

Phys Act Nutr

View full text Add to dashboard Cite

[Purpose] Research on the interaction between renal and lung functions has been conducted; however, studies on the general adult population are limited. This study aimed to investigate the association between serum creatinine levels and pulmonary function in Korean adults.[Methods] From the 2016–2019 Korean National Health and Nutrition Examination Survey, we recruited 11,380 participants who were 40 years or older for this study. Serum creatinine levels were divided into three groups: low, normal, and high. Pulmonary function was divided into three groups: normal, restrictive, and obstructive. The odds ratios for abnormal pulmonary function patterns were calculated using weighted multinomial logistic regression analysis.[Results] The odds ratios were 0.97 for low vs. normal (0.40–2.33) and 2.00 for high vs. normal (1.18–3.38) for the restrictive pattern, and 0.12 for low vs. normal (0.02–0.49) and 1.74 for high vs. normal (0.90–3.35) for the obstructive pattern after being adjusted for age, sex, smoking status, alcohol consumption, regular exercise, body mass index, diabetes mellitus, hypertension, cardiovascular disease, total energy, and total proteins.[Conclusion] High serum creatinine levels were associated with an increased odds ratio for restrictive and obstructive pulmonary function patterns. The odds ratio of the restrictive pattern was higher than that of the obstructive pattern. Screening for abnormal pulmonary function in individuals with high serum creatinine levels may be useful to ensure that there is no abnormal pulmonary function before the onset of potential pulmonary problems. Thus, this study highlights the relationship between renal and pulmonary function using serum creatine levels, which can be easily tested in the primary medical environment of the general population.

show abstract

“…The National Health and Nutrition Examination Survey 2007–2012 investigated 7610 participants aged 40–79 years and revealed that impaired lung function is common in those with and without chronic kidney disease, and eGFR <60 ml/min/1.73 m2 was associated with higher odds of obstructive lung function [3]. In another small Japanese sample, it was also found that decreased eGFR is associated with decreased pulmonary function markers of pulmonary diffusion capacity [21]. In another cohort study incorporating vascular surgery patients, chronic obstructive pulmonary disease (COPD) was found to be associated with restricted renal function and chronic kidney disease [22].…”

Section: Discussionmentioning

confidence: 99%

Association between pulmonary function and renal function: findings from China and Australia

Chen

Cai

et al. 2017

BMC Nephrol

View full text Add to dashboard Cite

BackgroundThe relationship between obstructive lung function and impaired renal function is unclear. This study investigated the dose-response relationship between obstructive lung function and impaired renal function.MethodsTwo independent cross-sectional studies with representative sampling were applied. 1454 adults from rural Victoria, Australia (1298 with normal renal function, 156 with impaired renal function) and 5824 adults from Nanjing, China (4313 with normal renal function, 1511 with impaired renal function). Pulmonary function measurements included forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Estimated glomerular filtration rate (eGFR), and impaired renal function marked by eGFR <60 mL/min/1.73m2 were used as outcome.ResultseGFR increased linearly with FEV1 in Chinese participants and with FVC in Australians. A non-linear relationship with peaked eGFR was found for FEV1 at 2.65 L among Australians and for FVC at 2.78 L among Chinese participants, respectively. A non-linear relationship with peaked eGFR was found for the predicted percentage value of forced expiratory volume in 1 s (PFEV1) at 81–82% and for the predicted percentage value of forced vital capacity (PFVC) at 83–84% among both Chinese and Australian participants, respectively.The non-linear dose-response relationships between lung capacity measurements (both for FEV1 and FVC) and risk of impaired renal function were consistently identified in both Chinese and Australian participants. An increased risk of impaired renal function was found below 3.05 L both for FEV1 and FVC, respectively. The non-linear relationship between PFEV and PVC and the risk of impaired renal function were consistently identified in both Chinese and Australian participants. An increased risk of impaired renal function was found below 76–77% for PFEV1 and 79–80% for PFVC, respectively.ConclusionsIn both Australian and Chinese populations, the risk of impaired renal function increased both with FEV1 and FVC below 3.05 L, with PFEV1 below 76–77% or with PFVC below 79–80%, respectively. Obstructive lung function was associated with increased risk of reduced renal function. The screen for impaired renal function in patients with obstructive lung disease might be useful to ensure there was no impaired renal function before the commencement of potentially nephrotoxic medication where indicated (eg diuretics).Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-017-0565-y) contains supplementary material, which is available to authorized users.

show abstract

Impact of kidney function and urinary protein excretion on pulmonary function in Japanese patients with chronic kidney disease

Abstract: This study suggests that decreased eGFR is associated with decreased %DLCO in proteinuric patients.

Cited by 6 publications

References 38 publications

Relationship between pulmonary function and albuminuria in type 2 diabetic patients with preserved renal function

Relationship between pulmonary function and albuminuria in type 2 diabetic patients with preserved renal function

Association between serum creatinine levels and pulmonary function of Korean adults: the 2016-2019 Korea National Health and Nutrition Examination Survey

Association between pulmonary function and renal function: findings from China and Australia

Contact Info

Product

Resources

About