Impact of intracytoplasmic morphologically selected sperm injection on assisted reproduction outcome: a review

Nadalini, Marco; Tarozzi, Nicoletta; Distratis, V; Scaravelli, Giulia; Borini, Andrea

doi:10.1016/s1472-6483(10)60283-0

Cited by 69 publications

(41 citation statements)

References 46 publications

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“…Using this technique, it is possible to observe morphological abnormalities in sperm cells, which are not visible with magnification ×400 (Fig. 1) (Antinori et al 2008, Nadalini et al 2009, Montjean et al 2012, Gatimel et al 2013.…”

Section: Evaluation Of Sperm Morphologymentioning

confidence: 99%

Evaluation of morphological criteria of sperm quality before in vitro fertilization and intracytoplasmic sperm injection

Lasienë

Gedrimas

Vitkus

et al. 2013

Polish Journal of Veterinary Sciences

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The quality of sperm has a direct influence on the fertilization and developmental competence of embryos. In the literature we did not find defined criteria for evaluation of normal sperm parameters in various species of domestic mammals. Therefore we attempted to review evaluation of criteria of morphologically normal human sperm and their abnormalities. All sperm cells observed in the stained sample are classified as normal or abnormal. Any abnormalities in morphology of sperm have a negative effect on the outcome in in vitro fertilization and intracytoplasmic sperm injection. Abnormal sperm are categorized into subgroups according to the observed defects (concerning the head and/or midpiece and/or tail). Most morphologically abnormal sperm have multiple defects. This article can be considered as guideline for the manual of sperm quality evaluation in different species of domestic mammals.

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Section: Evaluation Of Sperm Morphologymentioning

confidence: 99%

Evaluation of morphological criteria of sperm quality before in vitro fertilization and intracytoplasmic sperm injection

Lasienë

Gedrimas

Vitkus

et al. 2013

Polish Journal of Veterinary Sciences

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“…MSOME has been applied to the selection of sperm for ICSI [9,10,12,15]. This technique, termed intracytoplasmic morphology selected sperm injection (IMSI, [16,17]) has been reported to increase pregnancy rates and reduce spontaneous pregnancy loss in ICSI cycles [10,[17][18][19][20]. In particular, data from IMSI cycles has suggested that the presence of vacuoles in the nuclei of motile spermatozoa negatively affects reproductive outcome [10], although it has been suggested that these are derived from the acrosome region and are simply indicative of the presence of the acrosome [21].…”

Section: Introductionmentioning

confidence: 99%

Intracytoplasmic injection of morphologically selected spermatozoa (IMSI) improves outcome after assisted reproduction by deselecting physiologically poor quality spermatozoa

Wilding¹,

Coppola²,

Matteo

et al. 2010

J Assist Reprod Genet

118

100

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Purpose We used computer assisted sperm selection (MSOME) during cycles of intracytoplasmic sperm injection to test whether this technique improves results over traditional ICSI protocols. We also used the TUNEL assay to test whether MSOME could deselect physiologically abnormal spermatozoa. Methods Individual spermatozoa were examined with MSOME. Normal and abnormal spermatozoa were tested for the level of DNA fragmentation using TUNEL assay. In a prospective, randomized trial, patients were selected for standard ICSI, or IMSI techniques. We tested the two groups for biological and clinical parameters. Results 64.8% of spermatozoa, otherwise selectable for ICSI, were characterized by abnormalities after computer-assisted sperm analysis. These sperm were also characterized by an increase in the level of DNA fragmentation. We noted an increase in embryo quality, pregnancy and implantation rates after computerized sperm selection during ICSI procedures. Conclusions Computerised selection of spermatozoa during ICSI procedures deselects physiological abnormal spermatozoa and improves clinical results.

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“…Others have substantiated these findings and shown a significant and clear trend for better results in the IMSI group, particularly for ongoing pregnancy and live birth rates (both nearly doubled) and miscarriage (about 50 % reduced) [65,98,117]. Patients with poor sperm quality have been reported to benefit the most from the IMSI procedure [8,88], and indeed, this procedure is mainly offered to couples with male factor infertility and embryos of poor morphological quality.…”

Section: Male Contribution To Embryo Competence For Implantationmentioning

confidence: 89%

Assessment and treatment of repeated implantation failure (RIF)

Simon

Laufer

2012

J Assist Reprod Genet

210

161

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Repeated implantation failure (RIF) is determined when embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant. New methods of time-lapse imaging of embryos and assessment of their metabolic functions may improve selection of embryos for transfer, and subsequent outcomes for IVF patients, as well as for those diagnosed with RIF. This review discusses the various causes associated with RIF and addresses appropriate treatments.

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Impact of intracytoplasmic morphologically selected sperm injection on assisted reproduction outcome: a review

Cited by 69 publications

References 46 publications

Evaluation of morphological criteria of sperm quality before in vitro fertilization and intracytoplasmic sperm injection

Evaluation of morphological criteria of sperm quality before in vitro fertilization and intracytoplasmic sperm injection

Intracytoplasmic injection of morphologically selected spermatozoa (IMSI) improves outcome after assisted reproduction by deselecting physiologically poor quality spermatozoa

Assessment and treatment of repeated implantation failure (RIF)

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