Impact of infections, preneoplasia and cancer on micronucleus formation in urothelial and cervical cells: A systematic review

Setayesh, Tahereh; Nersesyan, Armen; Kundi, Michael; Mišík, Miroslav; Fenech, Michael; Bolognesi, Claudia; Stopper, Helga; Parsadanyan, Gohar; Ernst, Benjamin Philipp; Knasmueller, Siegfried

doi:10.1016/j.mrrev.2020.108361

Cited by 10 publications

(5 citation statements)

References 104 publications

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“…In fact, a recent review shows that micronuclei are more suited for the prognosis of blood, colorectal, and urogenital cancers, but not for, e.g., skin and prostate cancer [17,77]. A better prognosis for urogenital cancers, to which kidney cancers belong, could be achieved by analyzing micronuclei in cells obtained from urine or directly from the affected tissue [78,79]. Furthermore, the patient population investigated in this study differed significantly from that of other studies.…”

Section: Discussionmentioning

confidence: 88%

Differential Modulation of Markers of Oxidative Stress and DNA Damage in Arterial Hypertension

Kreutzmann,

Kraus,

Christa

et al. 2023

Antioxidants

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Patients with arterial hypertension have an increased risk of developing tumors, particularly renal cell carcinoma. Arterial hypertension is linked to DNA damage via the generation of oxidative stress, in which an upregulated renin–angiotensin–aldosterone system plays a crucial role. The current study investigated surrogates of oxidative stress and DNA damage in a group of hypertensive patients (HypAll, n = 64) and subgroups of well (HypWell, n = 36) and poorly (HypPoor, n = 28) controlled hypertensive patients compared to healthy controls (n = 8). In addition, a longitudinal analysis was performed with some of the hypertensive patients. Markers for oxidative stress in plasma (SHp, D-ROM, and 3-nitrotyrosine) and urine (8-oxodG, 15-F2t-isoprostane, and malondialdehyde) and markers for DNA damage in lymphocytes (γ-H2AX and micronuclei) were measured. In HypAll, all markers of oxidative stress except malondialdehyde were increased compared to the controls. After adjustment for age, this association was maintained for the protein stress markers SHp and 3-nitrotyrosine. With regard to the markers for DNA damage, there was no difference between HypAll and the controls. Further, no significant differences became apparent in the levels of both oxidative stress and DNA damage between HypWell and HypPoor. Finally, a positive correlation between the development of blood pressure and oxidative stress was observed in the longitudinal study based on the changes in D-ROM and systolic blood pressure. In conclusion, we found increased oxidative stress in extensively treated hypertensive patients correlating with the level of blood-pressure control but no association with DNA damage.

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Section: Discussionmentioning

confidence: 88%

Differential Modulation of Markers of Oxidative Stress and DNA Damage in Arterial Hypertension

Kreutzmann,

Kraus,

Christa

et al. 2023

Antioxidants

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“…They were mainly used for MN screening but also other anomalies can be evaluated [15]. About 75 individual studies have been published so far; they concern the detection of eff ects caused by chemical exposures but also the diagnosis of bladder cancer [16].…”

Section: Resultsmentioning

confidence: 99%

“…Cervical cells were mainly scored in the course of routine Pap tests. The morphology of nuclear anomalies is similar to that of oral mucosa cells; a comprehensive review on the use of this test system and the methodology has been published by Setayesh et al [16,17].…”

Section: Resultsmentioning

confidence: 99%

“…It was also found that exposure to carcinogenic chemicals at workplaces led to MN formation in nasal and oral cells [14,24]. Only a few investigations concerned the impact of chemical carcinogens on MN formation in urothelial and cervical cells, diseases and infections which are associated with increased cancer risk (e.g., schistosomiasis, human papillomavirus, HPV), lead to elevated MN rates (for review, see [16,17]).…”

Section: Prediction Of Human Cancer Risksmentioning

confidence: 99%

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Use of Micronucleus Experiments for the Detection of Human Cancer Risks: A Brief Overview

Nersesyan

Mišík

Cherkas

et al. 2021

PSSS MS

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Introduction. Micronuclei (MN) are small extranuclear DNA-containing structures that are formed as a consequence of structural and numerical chromosomal aberrations. The advantage of MN experiments compared to conventional chromosomal analyses in metaphase cells is that the scoring is by far less time consuming and laborious. MN experiments are currently widely used for the routine screening of chemicals in vitro and in vivo but also for environmental control and human biomonitoring Objectives. The purpose of this review was to collect data on the use of MN experiments for the detection of increased cancer risks as a consequence of environmental, lifestyle and occupational exposures and the detection/diagnosis of different forms of cancer. Methods. Analysis of the literature on methods for MN experiments with humans; as well as the use of this technique in different areas of research. Results. To date, a wide range of protocols for human biomonitoring studies has been developed for the measurement of MN formation in peripheral blood cells and in epithelial from different organs (buccal and nasal cavity, cervix and bladder). In addition to MN, other nuclear anomalies can be scored which reflect genetic instability as well as acute toxicity and the division of target cells. Conclusions. The evidence is accumulating that MN can be used as a diagnostic tool for the detection of increased cancer risks as well as for the early diagnosis of cervical and bladder cancer

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“…They showed that viral infection increases frequencies of (i) koilocytotic cell (squamous epithelial cells with perinuclear cavitation and nuclear features of low-grade squamous intraepithelial lesions [LSIL]), (ii) cells with perinuclear halo (a vacuolated area that surrounds the nucleus), (iii) cells with micronuclei (MN). The latter endpoint is well known since many papers were published concerning this problem (see reviews 2,3 ). All other investigated endpoints (binucleated cells, budded cells, etc.)…”

mentioning

confidence: 97%

Re: “Cytomorphometry and morphology analysis of human papillomavirus type 16 in liquid‐based cervical cytology samples” by Safi Oz et al.

Nersesyan

Parsadanyan

2022

Diagnostic Cytopathology

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Impact of infections, preneoplasia and cancer on micronucleus formation in urothelial and cervical cells: A systematic review

Cited by 10 publications

References 104 publications

Differential Modulation of Markers of Oxidative Stress and DNA Damage in Arterial Hypertension

Differential Modulation of Markers of Oxidative Stress and DNA Damage in Arterial Hypertension

Use of Micronucleus Experiments for the Detection of Human Cancer Risks: A Brief Overview

Re: “Cytomorphometry and morphology analysis of human papillomavirus type 16 in liquid‐based cervical cytology samples” by Safi Oz et al.

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