Impact of hospitalisations for exacerbations of COPD on health-related quality of life

Esteban, Cristóbal; Quintana, José M.; Moraza, Javier; Aburto, Myriam; Egurrola, Mikel; España, Pedro Pablo; Pérez-Izquierdo, Julio; Aguirre, Urko; Aizpiri, Susana; Capelastegui, Alberto

doi:10.1016/j.rmed.2009.02.002

Cited by 70 publications

(64 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This questionnaire allows a more accurate assessment of the severity of the disease when other data remain inconclusive. Patients with frequent hospitalizations have been found to have an increase in the total SGRQ score [9]. …”

Section: Introductionmentioning

confidence: 99%

Predicting Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease: The Impact of Age

et al. 2016

View full text Add to dashboard Cite

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity in the elderly population. COPD leads to a reduced health-related quality of life (HRQL), but the factors which contribute to this are not well understood. A better understanding of the factors which determine HRQL should lead to an improved care for such patients. Objectives: The purpose of this study was to investigate possible age-related differences in HRQL in a population of patients with a similar severity of obstruction. Methods: A total of 180 consecutive COPD patients were enrolled into the study. We analyzed spirometric data, BODE index and its components, and comorbidities were assessed by the Charlson index. HRQL was assessed by the Clinical COPD Questionnaire (CCQ) and St. George's Respiratory Questionnaire (SGRQ). Results: The cohort consisted of 93 ‘younger' patients (mean age 54.8 ± 3.1 years) and 87 older patients (mean age 73.1 ± 5.5 years). Patients in both groups had a similar severity of obstruction: FEV₁ (% from predicted) was 39.9 ± 13.2% in the elderly group compared to 41.7 ± 11.7% in the younger group (p > 0.05). The forward stepwise regression analysis shows that the BODE index, the Charlson index, and the rate of exacerbations are important predictors of deterioration of HRQL in elderly COPD patients, which explains 29% of the total SGRQ score. In the younger COPD patients, the coefficient of determination R² was 0.27, but the predictors were the BODE index and the rate of exacerbations. Conclusions: The BODE index, the Charlson index, and the rate of exacerbations were found to be the major determinants of HRQL in elderly COPD patients, while in younger COPD patients, the BODE index and the rate of exacerbations were influential factors.

show abstract

Section: Introductionmentioning

confidence: 99%

Predicting Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease: The Impact of Age

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Different predictors have been associated with mortality depending on whether the endpoint is short or long term (1). Exacerbation is not only an established predictor of mortality in COPD (2) but is also considered an outcome (3) with its predictors (3) and consequences related to suffering exacerbations with different rate and severity, like decrement of pulmonary function (4) and health-related quality of life (HRQoL) (5,6).…”

Section: Introductionmentioning

confidence: 99%

One-year Mortality in COPD After an Exacerbation: The Effect of Physical Activity Changes During the Event

Esteban

García-Gutiérrez

Legarreta

et al. 2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

Self Cite

View full text Add to dashboard Cite

Mortality is one of the most important outcomes in patients with chronic obstructive pulmonary disease (COPD). Different predictors have been associated with mortality, including the patient's level of physical activity (PA). The objective of this work was to establish the relationship between changes in PA during a moderate-to-severe COPD exacerbation (eCOPD) and 1-year mortality after the index event. This was a prospective observational cohort study with recruitment of 2,484 patients with an eCOPD attending the emergency department (ED) of 16 participating hospitals. Variables recorded included clinical and sociodemographic data from medical records, dyspnea, health-related quality of life, and PA before the index eCOPD and 2 months after the hospital or ED discharge, as reported by the patient. In the multivariate analysis worsening changes in PA from baseline to 2 months after the ED index visit [odds ratio (ORs) from 2.78 to 6.31] was related to 1-year mortality, using the age-adjusted Charlson comorbidity index (OR: 1.22), and previous use of long-term domiciliary oxygen therapy or non-invasive mechanical ventilation at home (OR: 1.68). The same variables were also predictive in the validation sample. Areas under the receiver operating characteristic curve in the derivation and validation sample were 0.79 and 0.78, respectively. In conclusion, PA is the strongest predictor of dying in the following year, i.e., those with worsened PA from baseline to 2 months after an eCOPD or with very low PA levels have a higher risk.

show abstract

“…1 COPD is associated with progressive declines in respiratory function, mediated in part through frequent acute exacerbations as the disease worsens. 2,3 Declining respiratory function, in turn, leads to increased mortality risk, 4,5 reduced quality of life, [6][7][8] and greater risk of disability. 2,5,9,10 COPD also imposes a substantial economic burden.…”

mentioning

confidence: 99%

Effect of Hospital Use of Oral Nutritional Supplementation on Length of Stay, Hospital Cost, and 30-Day Readmissions Among Medicare Patients With COPD

Snider¹,

Jena

Linthicum³

et al. 2015

Chest

View full text Add to dashboard Cite

BACKGROUND: COPD is a leading cause of death and disability in the United States. Patients with COPD are at a high risk of nutritional defi ciency, which is associated with declines in respiratory function, lean body mass and strength, and immune function. Although oral nutritional supplementation (ONS ) has been associated with improvements in some of these domains, the impact of hospital ONS on readmission risk, length of stay (LOS), and cost among hospitalized patients is unknown.

show abstract

Impact of hospitalisations for exacerbations of COPD on health-related quality of life

Cited by 70 publications

References 25 publications

Predicting Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease: The Impact of Age

Predicting Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease: The Impact of Age

One-year Mortality in COPD After an Exacerbation: The Effect of Physical Activity Changes During the Event

Effect of Hospital Use of Oral Nutritional Supplementation on Length of Stay, Hospital Cost, and 30-Day Readmissions Among Medicare Patients With COPD

Contact Info

Product

Resources

About