Impact of HLA-C and Bw Epitopes Disparity on Liver Transplantation Outcome

Impact of Recipient HLA-C in Liver Transplant: A Protective Effect of HLA-Cw*07 on Acute Rejection

“…These findings also agree with the observations of Oertel et al [23], about the potential absence of association between NK alloreactivity and AR. Unlike the results of Bishara et al [24], which suggest an impact of the HLA-C epitope disparity in liver transplants, we find an influence on the part of the recipient HLA-C, although this discrepancy could be explained by the different sizes of the series in these two studies.…”

KIR Gene and KIR Ligand Analysis to Predict Graft Rejection After Renal Transplantation

“…So far, few studies have addressed the effects of NK cell alloreactivity based on KIR genotyping on the outcome of solid organ transplantation (31)(32)(33). Two studies evaluated the effect of NK cell alloreactivity based on the missing-self hypothesis (31,33).…”

“…Two studies evaluated the effect of NK cell alloreactivity based on the missing-self hypothesis (31,33). In a cohort of liver transplant patients, patients receiving a graft that lacked the expression of self HLA-Cw and HLA-Bw4 epitopes experienced a significantly higher number of acute rejection episodes in the first year after transplantation as compared to patients that received a graft that expressed the same HLA epitopes as the patient (31).…”

Donor HLA-C Genotype Has a Profound Impact on the Clinical Outcome Following Liver Transplantation

“…KIR2DL2/3 proteins bind HLA-C alleles carrying an asparagine at position 80 while KIR2DL1 recognizes HLA-C alleles with a lysine at this position. These two HLA-C types are termed group 1 (HLA-C1) and group 2 (HLA-C2), respectively (19), and all HLA-C allotypes ( (22,23), neoplastic (24) and infectious diseases (20), as well as outcome following hematopoietic stem cell transplantation (25 (26); whereas for liver transplants an association with acute rejection has been observed (27,28 (Figure 2A). Figure 2C) but no effect was seen on the development of hepatic artery thrombosis ( Figure 2D).…”