Impact of heat stress on milk yield, antioxidative levels, and serum metabolites in primiparous and multiparous Holstein cows

Chen, Xue; Dong, Jia Nan; Rong, Ji Ye; Xiao, Jun; Wang, Zhao; Aschalew, Natnael D.; Zhang, Xue Feng; Wang, Tao; Qin, Guixin; Sun, Zhe; Zhen, Yuguo

doi:10.1007/s11250-022-03159-x

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…Heat stressed cows at higher temperature humidity index (THI = 83.4) have had significantly lesser milk yield (31.2 vs. 38.6 kg/d) than the control cows at thermo-neutral conditions (THI = 75.7) [ 11 ]. Similar effects on the milk yield were observed during the season with high temperature and humidity [ 12 , 13 ]. These deleterious effects on milk production and health of animals stem from the heat stress induced molecular changes that alter normal physiological mechanisms [ 14 , 15 ].…”

Section: Introductionsupporting

confidence: 67%

Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle

et al. 2023

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Environmental heat stress in dairy cattle leads to poor health, reduced milk production and decreased reproductive efficiency. Multiple genes interact and coordinate the response to overcome the impact of heat stress. The present study identified heat shock regulated genes in the peripheral blood mononuclear cells (PBMC). Genome-wide expression patterns for cellular stress response were compared between two genetically distinct groups of cattle viz., Hariana (B. indicus) and Vrindavani (B. indicus X B. taurus). In addition to major heat shock response genes, oxidative stress and immune response genes were also found to be affected by heat stress. Heat shock proteins such as HSPH1, HSPB8, FKB4, DNAJ4 and SERPINH1 were up-regulated at higher fold change in Vrindavani compared to Hariana cattle. The oxidative stress response genes (HMOX1, BNIP3, RHOB and VEGFA) and immune response genes (FSOB, GADD45B and JUN) were up-regulated in Vrindavani whereas the same were down-regulated in Hariana cattle. The enrichment analysis of dysregulated genes revealed the biological functions and signaling pathways that were affected by heat stress. Overall, these results show distinct cellular responses to heat stress in two different genetic groups of cattle. This also highlight the long-term adaptation of B. indicus (Hariana) to tropical climate as compared to the crossbred (Vrindavani) with mixed genetic makeup (B. indicus X B. taurus).

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Section: Introductionsupporting

confidence: 67%

Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle

et al. 2023

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“…It is well known that genetics, parity, diets and environmental management have an impact on the milk yield and milk composition of dairy cows. In addition, heat stress can significantly reduce milk yield, with the milk yield of primiparous cows being more easily affected by heat stress (Chen et al., 2022 ). Even cows fed the same diet under the same management presented wide variations in milk production.…”

Section: Discussionmentioning

confidence: 99%

The physiological dissimilarities of Holstein dairy cows with different milk yields

Dong

Liu

et al. 2022

Veterinary Medicine & Sci

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Background Even if breed, parity, dietary and environmental management are same, dairy cows still have notable differences in milk yield that may be underpinned by physiologic differences. Objectives This study aimed to investigate the physiological dissimilarities of dairy cows with different milk yields. Methods Thirty cows were sorted into high milk‐yielding cows (group H: 58.93±2.31 kg/day), moderate milk‐yielding cows (group M: 44.99±0.54 kg/day), and low milk‐yielding cows (group L: 24.99±6.83 kg/day) according to milk yield. Blood was collected and serum parameters were assessed. Rumen fluid was collected for the evaluation of rumen fermentation parameters (RFPs) and bacterial community composition (BCC). Results Serum prolactin, growth hormone, glutathione peroxidase, immunoglobulin A and non‐esterified fatty acid had a significantly positive correlation with milk yield ( p < 0.05), whereas serum glucagon and total antioxidant capacity had a significantly negative correlation with milk yield ( p < 0.05). The concentration of valeric acid and the ratio of acetic acid to propionic acid in the rumen fluid in group H was significantly lower than that in group L ( p < 0.05). The concentration of acetic acid and butyric acid in group H was significantly lower than that in groups M and L ( p < 0.05). The relative abundances of Ruminococcaceae_NK4A214 _group, Prevotella_1 , Rikenellaceae_RC9_gut_group , Christensenellaceae_R‐7_group , Muribaculaceae , and Ruminococcus_2 were negatively correlated with milk yield, whereas the relative abundance of Succinivibrionaceae_UCG‐001 , Lachnospiraceae_NK3A20_group, Shuttleworthia and Dialister were positively correlated with milk yield ( p < 0.05). Conclusions This study indicates that dairy cows with different milk yields have clear divergence in serum indicators, RFPs, BCC and rumen microbial metabolism.

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“…This might be due to the fact that heat stress can lead to an aggravation of lipid peroxidation and a decrease in total antioxidant capacity in dairy cows at different lactation stages. Moreover, heat stress negatively impacts feed intake, milk yield, and negative energy balance in early lactation [ 51 ]. However, in Sum1 and Spr2 groups, the largest number of DE circRNAs were enriched in heat-stress-related signaling pathways such as autophagy.…”

Section: Discussionmentioning

confidence: 99%

Analysis of CircRNA Expression in Peripheral Blood of Holstein Cows in Response to Heat Stress

Zhang

Wang

et al. 2023

IJMS

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The present study aimed to identify key circRNAs and pathways associated with heat stress in blood samples of Holstein cows, which will provide new insights into the molecular mechanisms driving heat stress in cows. Hence, we evaluated changes in milk yield, rectal temperature, and respiratory rate of experimental cows between heat stress (summer) and non-heat stress (spring) conditions with two comparisons, including Sum1 vs. Spr1 (same lactation stage, different individuals, 15 cows per group) and Sum1 vs. Spr2 (same individual, different lactation stages, 15 cows per group). Compared to both Spr1 and Spr2, cows in the Sum1 group had a significantly lower milk yield, while rectal temperature and respiratory rate were significantly higher (p < 0.05), indicating that cows in the Sum1 group were experiencing heat stress. In each group, five animals were chosen randomly to undergo RNA-seq. The results reveal that 140 and 205 differentially expressed (DE) circRNAs were screened in the first and second comparisons, respectively. According to the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, these DE circRNAs were mainly enriched in five signaling pathways, including choline metabolism, the PI3K/AKT signaling pathway, the HIF-1 signaling pathway, the longevity-regulating pathway, and autophagy. Then, we obtained the top 10 hub source genes of circRNAs according to the protein–protein interaction networks. Among them, ciRNA1282 (HIF1A), circRNA4205 (NR3C1), and circRNA12923 (ROCK1) were enriched in multiple pathways and identified as binding multiple miRNAs. These key circRNAs may play an important role in the heat stress responses of dairy cows. These results provide valuable information on the involvement of key circRNAs and their expression pattern in the heat stress response of cows.

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Impact of heat stress on milk yield, antioxidative levels, and serum metabolites in primiparous and multiparous Holstein cows

Cited by 11 publications

References 30 publications

Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle

Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle

The physiological dissimilarities of Holstein dairy cows with different milk yields

Analysis of CircRNA Expression in Peripheral Blood of Holstein Cows in Response to Heat Stress

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