2018
DOI: 10.3389/fgene.2018.00586
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Abstract: Mutations of a single gene can lead to a major increase in longevity in organisms ranging from yeast and worms to insects and mammals. Discovering these mutations (sometimes referred to as “longevity genes”) led to identification of evolutionarily conserved molecular, cellular, and organismal mechanisms of aging. Studies in mice provided evidence for the important role of growth hormone (GH) signaling in mammalian aging. Mice with mutations or gene deletions leading to GH deficiency or GH resistance have reduc… Show more

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Cited by 36 publications
(36 citation statements)
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“…We do not currently understand the precise mechanism for this discrepancy, but believe that the most likely explanation is the difference in the age of the animals at the time of transferring them from 23°C to 30°C. The suggested importance of exposing juvenile versus adult mice to increased eT is consistent with the well‐documented potential of early life nutritional, hormonal, or environmental interventions to influence adult phenotypic characteristics, including rate of aging and longevity (Barker, ; Bartke & Quainoo, ; Sun et al,). The data generated in adult Ames dwarf mice concerning energy metabolism (Darcy et al, ) are likely influenced by profound suppression of thyroid function in these animals.…”
Section: Conclusion and Discussionsupporting
confidence: 53%
“…We do not currently understand the precise mechanism for this discrepancy, but believe that the most likely explanation is the difference in the age of the animals at the time of transferring them from 23°C to 30°C. The suggested importance of exposing juvenile versus adult mice to increased eT is consistent with the well‐documented potential of early life nutritional, hormonal, or environmental interventions to influence adult phenotypic characteristics, including rate of aging and longevity (Barker, ; Bartke & Quainoo, ; Sun et al,). The data generated in adult Ames dwarf mice concerning energy metabolism (Darcy et al, ) are likely influenced by profound suppression of thyroid function in these animals.…”
Section: Conclusion and Discussionsupporting
confidence: 53%
“…It accelerates after reproductive age, when the genes have already been passed on to the next generation, and several mechanisms are currently proposed to accelerate this process. Based on animal studies and some human data, Bartke et al propose that the elevated plasma level of growth hormone (GH) and IGF-I have a negative effect on life span [17]. In particular, low levels of circulating in blood IGF-I or somatomedin C, which is secreted from the liver in response to GH, has been shown to be a predictive marker of longevity in mice and humans.…”
Section: Discussionmentioning
confidence: 99%
“…These animals appeared to be more resistance to stress, were generally healthier and displayed extended longevity. However, no consistent effects on life span were observed in an examination of humans with similar mutations [28].…”
Section: Intraspecies Comparisons Linking Growth Rate and Longevitymentioning
confidence: 91%