Impact of Gastroesophageal Reflux on Survival in the Community

Talley, Nicholas J.; Locke, G. Richard; McNally, Meredythe A.; Schleck, Cathy D.; Zinsmeister, Alan R.; Melton, L. Joseph

doi:10.1111/j.1572-0241.2007.01546.x

Cited by 19 publications

(14 citation statements)

References 36 publications

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“…The results of this study align with those from a smaller population-based cohort study from the USA, which found no difference in all-cause mortality between 115 individuals with daily and 2708 individuals without reflux symptoms 18. A cohort study from the UK found that patients with GORD (n=7159) had a 60% increased all-cause mortality within the first year of follow-up after inclusion, compared with patients without GORD (n=10 000), but no difference was seen for the remaining 4 years of follow-up 19.…”

Section: Discussionsupporting

confidence: 87%

All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study)

Ness-Jensen

Gottlieb‐Vedi

Wahlin

et al. 2016

Gut

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Objective: Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancer. The aim of this study was to test the hypothesis that reflux increases all-cause and cancer-specific mortality in an unselected cohort. Design:The Nord-Trøndelag health study (HUNT), a Norwegian population-based cohort study, was used to identify individuals with and without reflux in 1995-1997 and 2006-2008, with follow-up until 2014. All-cause and cancer-specific mortality were assessed from the Norwegian Causes of Death Registry and Cancer Registry. Multivariable Cox-regression was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for mortality with adjustments for potential confounders. Results:We included 4,758 participants with severe reflux symptoms and 51,381 participants without reflux symptoms, contributing 60,323 and 747,239 person-years at risk, respectively. Severe reflux was not associated with all-cause mortality, overall cancerspecific mortality, or mortality in cancer of the head-and-neck or lung. However, for men with severe reflux a 6-fold increase in oesophageal adenocarcinoma-specific mortality was found (HR 6.09, 95% CI 2.33 to 15.93) and the mortality rate was 0.27 per 1000 personyears. For women, the corresponding mortality was not significantly increased (HR 3.68, 95% CI 0.88 to 15.27) and the mortality rate was 0.05 per 1000 person-years. Conclusion:Individuals with severe reflux symptoms do not seem to have increased allcause mortality or overall cancer-specific mortality. Although the absolute risk is small, individuals with severe reflux symptoms have a clearly increased oesophageal adenocarcinoma-specific mortality.4

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Section: Discussionsupporting

confidence: 87%

All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study)

Ness-Jensen

Gottlieb‐Vedi

Wahlin

et al. 2016

Gut

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“…16 As circulatory diseases are the major causes of death in the United States, 28 it is likely that this inverse association was mainly related to circulatory diseases, consistent with our finding. The reason for this inverse association is unclear.…”

Section: Discussionsupporting

confidence: 86%

“…15 Finally, a study from the United States showed no association between daily GERD symptoms and mortality, and there were inverse associations between weekly and less than weekly symptoms and mortality. 16 There has been no published population-based study from non-Western countries on the association between GERD and overall mortality. …”

Section: Introductionmentioning

confidence: 99%

Tu1864 Gastroesophageal Reflux Disease and Overall and Cause-Specific Mortality -A Prospective Study of 50,000 Individuals

Islami¹,

Pourshams²,

Nasseri‐Moghaddam³

et al. 2014

Gastroenterology

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“…Individuals with long‐standing GERD have an increased risk of oesophageal adenocarcinoma 38 . Mortality in individuals with GERD has been reported to be increasing, 39 although a recent study showed that reflux symptoms were not associated with worse survival 40 . There is no confirmation that PPIs prevent BO or adenocarcinoma, but some uncontrolled studies suggest that they may reduce the progression of Barrett’s epithelium to dysplasia 41, 42 .…”

Section: Discussionmentioning

confidence: 99%

Systematic review: persistence and severity in gastro‐oesophageal reflux disease

Armstrong

2008

Aliment Pharmacol Ther

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Impact of Gastroesophageal Reflux on Survival in the Community

Abstract: In this population-based study with over 50,000 person-years of follow-up, reflux symptoms were not associated with worse survival. The vast majority of heartburn sufferers can be reassured of the benign nature of their condition.

Cited by 19 publications

References 36 publications

All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study)

All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study)

Tu1864 Gastroesophageal Reflux Disease and Overall and Cause-Specific Mortality -A Prospective Study of 50,000 Individuals

Systematic review: persistence and severity in gastro‐oesophageal reflux disease

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