Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males

Jones, Helen; Nyakayiru, Jean; Bailey, Tom G.; Green, Daniel; Cable, N. Timothy; Sprung, Victoria S.; Hopkins, Nicola; Thijssen, Dick H. J.

doi:10.1177/2047487314547657

Cited by 65 publications

(98 citation statements)

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“…Combining these effects may be of clinical relevance, because the 'early' and 'late' phases may have distinct protective mechanisms (Bolli, 2000). Given the relatively long duration of the 'late' phase of protection, we explored whether less frequent (and arguably more practical) exposure to repeated IPC is sufficient to induce vascular adaptation (Jones et al 2015). We found that 8 weeks of IPC (three cycles per week) significantly improved brachial artery endothelial function and that this effect was evident after 2 weeks (i.e.…”

Section: What Are the Cardiovascular Adaptations To Repeated Ipc?mentioning

confidence: 99%

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Thijssen

Maxwell

Green

et al. 2016

Experimental Physiology

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Professor Dick H. J. Thijssen's work is focused on the (primary and secondary) prevention of cardiovascular disease. His work focuses on exploring and understanding the benefits of exercise training and (repeated) ischaemic preconditioning, but also examines the link between the preconditioning effects of exercise and ischaemic preconditioning. The benefits of these interventions are linked to improvement in micro-and macrovessel function and structure, and he explores factors that moderate these effects (e.g. older age, cardiovascular disease). The benefits on the arterial wall, but also activation of the preconditioning pathways, may contribute to the reduction in cardiovascular risk associated with both interventions. His work also aims to understand (haemodynamic) stimuli, such as shear stress and arterial pressure, that mediate improvement in vascular function and structure. Ultimately, this work contributes to identification of (non-)pharmacological strategies in the management of patients with cardiovascular risk and/or disease. New Findings r What is the topic of this review?This review discusses the effects of repeated exposure of tissue to ischaemic preconditioning on cardiovascular function, the attendant adaptations and their potential clinical relevance. r What advances does it highlight?We discuss the effects of episodic exposure to ischaemic preconditioning to prevent and/or attenuate ischaemic injury and summarize evidence pertaining to improvements in cardiovascular function and structure. Discussion is provided regarding the potential mechanisms that contribute to both local and systemic adaptation. Findings suggest that clinical benefits result from both the prevention of ischaemic events and the attenuation of their consequences.Ischaemic preconditioning (IPC) refers to the phenomenon whereby short periods of cyclical tissue ischaemia confer subsequent protection against ischaemia-induced injury. As a consequence, IPC can ameliorate the myocardial damage following infarction and can reduce infarct size. The ability of IPC to confer remote protection makes IPC a potentially feasible cardioprotective strategy. In this review, we discuss the concept that repeated exposure of tissue to IPC may increase the 'dose' of protection and subsequently lead to enhanced protection against ischaemia-induced myocardial injury. This may be relevant for clinical populations, who demonstrate attenuated efficacy of IPC to prevent or attenuate ischaemic injury (and therefore myocardial infarct size).

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Section: What Are the Cardiovascular Adaptations To Repeated Ipc?mentioning

confidence: 99%

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Thijssen

Maxwell

Green

et al. 2016

Experimental Physiology

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“…As shown in Table 1, all studies examined the acute effects of IPC on exercise performance; therefore, little is known of the possible effects of repeated IPC. To the best of our knowledge, only one study investigated the effects of a regular routine of IPC on vasculature and fitness level for a period of eight weeks 29) . As this recent study mainly focused on the effects of repeated IPC on vascular function, detailed outcomes with regard to exercise performance were not evaluated; the study failed to observe improvement in aerobic fitness level 29) .…”

Section: Ipc Protocolmentioning

confidence: 99%

“…To the best of our knowledge, only one study investigated the effects of a regular routine of IPC on vasculature and fitness level for a period of eight weeks 29) . As this recent study mainly focused on the effects of repeated IPC on vascular function, detailed outcomes with regard to exercise performance were not evaluated; the study failed to observe improvement in aerobic fitness level 29) . Since this study is insufficient evidence of repeated IPC effects on exercise performance, future studies are needed.…”

Section: Ipc Protocolmentioning

confidence: 99%

“…studies, regular, repeated remote IPC has shown positive effects on vascular 29,[34][35][36][37] , cardiac [38][39][40] , and brain functions 41,42) . Together, IPC did not improve exercise performance in these populations; however, it appears that remote IPC may have positive effects in clinical outcomes.…”

Section: Population Differencesmentioning

confidence: 99%

“…Previous studies on IPC and exercise performance were mostly conducted on healthy and young trained athletes and elite athletes (see Table 1). All studies, except for one by Jones et al (2014) 29) , were cross-sectional studies. Further research is therefore needed to explain the effects of training status (level) with IPC and/or repeated IPC on exercise performance.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

See 2 more Smart Citations

Ischemic preconditioning: Potential impact on exercise performance and underlying mechanisms

Horiuchi

2017

JPFSM

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Originally, in clinical settings, ischemic preconditioning (IPC) has been used to delay cardiac cell injury and protect against myocardial and vascular damage. Furthermore, as this manipulation is relatively easy and noninvasive, previous studies have examined how IPC may have beneficial effects on exercise performance. However, because of various factors, such as different populations, exercise modes and intensities, and IPC protocols, not enough evidence is available to achieve a consensus on the impact of IPC on exercise performance, e.g., time to failure during exercise, time trial performance, and peak power. Existing evidence suggests that IPC seems not to impair exercise performance, though one study found an impairment. However, about half of the previous studies showed beneficial effects of IPC on exercise performance. Similarly, the physiological responses from IPC are varied. It is still possible that various factors, such as exercise mode and intensity, heterogeneous population and IPC protocol may affect exercise performance. Previous studies showed that effective blood flow via an increase in nitric oxide and the improvement of metabolic efficiency might be candidate factors that can explain the effect of IPC on exercise performance, although no direct evidence has been obtained. This review aims to identify potential sources of variation in these effects on exercise performance with IPC.

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Remote ischemic preconditioning accelerates systemic O₂ dynamics and enhances endurance during work-to-work cycling exercise

et al. 2018

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The effect of remote ischemic preconditioning (RIPC) on whole‐body exercise performance and its potential mechanism remains poorly understood. In this study, we examined whether RIPC can accelerate systemic and local O2 dynamics and can enhance endurance during the work‐to‐work cycling exercise. Thirteen healthy men were instructed to perform the work‐to‐work test, which was preceded by the RIPC (bilateral arm occlusion, 3 × 5 minutes) or control (CON; no occlusion) condition. This test involved gradually increasing the exercise intensity as follows: low intensity at 30 W for 3 minutes, moderate intensity at 90% of the gas exchange threshold (GET) for 4 minutes, and severe intensity at 70% of the difference between the GET and VO2 peak until exhaustion. During the test, breath‐by‐breath pulmonary VO2 and near‐infrared spectroscopy‐derived vastus lateralis muscle deoxygenation were recorded continuously. Pulmonary VO2 dynamics during moderate‐intensity exercise was significantly faster in RIPC than in CON. In contrast, no such difference in muscle deoxygenation kinetics was observed between the two conditions. Time until exhaustion during severe‐intensity exercise was significantly longer in RIPC than in CON. These findings suggest that RIPC may be a beneficial strategy for enhancing whole‐body exercise performance, which may partially result from accelerated systemic O2 dynamics during exercise.

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Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males

Cited by 65 publications

References 20 publications

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Ischemic preconditioning: Potential impact on exercise performance and underlying mechanisms

Remote ischemic preconditioning accelerates systemic O₂ dynamics and enhances endurance during work-to-work cycling exercise

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Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males

Cited by 65 publications

References 20 publications

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Repeated ischaemic preconditioning: a novel therapeutic intervention and potential underlying mechanisms

Ischemic preconditioning: Potential impact on exercise performance and underlying mechanisms

Remote ischemic preconditioning accelerates systemic O2 dynamics and enhances endurance during work-to-work cycling exercise

Contact Info

Product

Resources

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Remote ischemic preconditioning accelerates systemic O₂ dynamics and enhances endurance during work-to-work cycling exercise