Impact of Duration of Neoadjuvant Radiation on Rectal Cancer Survival: A Real World Multi-center Retrospective Cohort Study

Utilization of short-course radiation therapy for patients with nonmetastatic rectal adenocarcinoma in the United States

“…Patients who received neoadjuvant treatment with SCRT rather than LCRT were older, had more medical comorbidities, and tended to have earlier stage disease or more favorable disease. This is in line with previous retrospective studies, 16 and may be due to the logistical convenience of SCRT compared with LCRT among groups of patients with compromised general conditions.…”

Utilization of short-course radiation therapy for patients with nonmetastatic rectal adenocarcinoma in the United States

“…Patients who received neoadjuvant treatment with SCRT rather than LCRT were older, had more medical comorbidities, and tended to have earlier stage disease or more favorable disease. This is in line with previous retrospective studies, 16 and may be due to the logistical convenience of SCRT compared with LCRT among groups of patients with compromised general conditions.…”

Neoadjuvant therapy in rectal cancer: how are we choosing?

“…In our study, clinical node positivity was an independent predictor for receiving LCR over SCR. This is in line with findings of a recent cohort study that demonstrated that patients staged as N1 or N2 were more likely to receive LCR over SCR (OR 5.08, CI 2.51–11.22, P < 0.0001 and OR 8.35, CI 3.35–22.39, P < 0.001, respectively) . However, almost a third of presumed node‐positive patients in our cohort who received neoadjuvant therapy, had SCR rather than LCR, suggesting that it is not the only factor driving decision‐making.…”

Preoperative short-course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer: Meta-analysis with trial sequential analysis of long-term survival data

“…Based on the inclusion and exclusion criteria, 217 studies were excluded and 21 studies were subjected to a more detailed review. Finally, 11 studies (4 RCTs [ 10 , 13 – 15 ] and 7 non-RCTs [ 28 – 34 ]) with a total of 1984 patients were included in this meta-analysis.…”

“…11 included studies all analyzed OS and DFS, and 10 of them analyzed LR. 4 RCTs [ 10 , 13 – 15 ] out of the 11 studies earned scores of 6 for quality assessment based on the modified Jadad scale, and the 7 non-RCTs [ 28 – 34 ] were scored 4.…”

Utilization of short-course radiation therapy for patients with nonmetastatic rectal adenocarcinoma in the United States

“…Patients who received neoadjuvant treatment with SCRT rather than LCRT were older, had more medical comorbidities, and tended to have earlier stage disease or more favorable disease. This is in line with previous retrospective studies, 16 and may be due to the logistical convenience of SCRT compared with LCRT among groups of patients with compromised general conditions.…”

Neoadjuvant therapy in rectal cancer: how are we choosing?

“…In our study, clinical node positivity was an independent predictor for receiving LCR over SCR. This is in line with findings of a recent cohort study that demonstrated that patients staged as N1 or N2 were more likely to receive LCR over SCR (OR 5.08, CI 2.51–11.22, P < 0.0001 and OR 8.35, CI 3.35–22.39, P < 0.001, respectively) . However, almost a third of presumed node‐positive patients in our cohort who received neoadjuvant therapy, had SCR rather than LCR, suggesting that it is not the only factor driving decision‐making.…”

Preoperative short-course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer: Meta-analysis with trial sequential analysis of long-term survival data

“…Based on the inclusion and exclusion criteria, 217 studies were excluded and 21 studies were subjected to a more detailed review. Finally, 11 studies (4 RCTs [ 10 , 13 – 15 ] and 7 non-RCTs [ 28 – 34 ]) with a total of 1984 patients were included in this meta-analysis.…”

“…11 included studies all analyzed OS and DFS, and 10 of them analyzed LR. 4 RCTs [ 10 , 13 – 15 ] out of the 11 studies earned scores of 6 for quality assessment based on the modified Jadad scale, and the 7 non-RCTs [ 28 – 34 ] were scored 4.…”

Utilization of short-course radiation therapy for patients with nonmetastatic rectal adenocarcinoma in the United States

“…Patients who received neoadjuvant treatment with SCRT rather than LCRT were older, had more medical comorbidities, and tended to have earlier stage disease or more favorable disease. This is in line with previous retrospective studies, 16 and may be due to the logistical convenience of SCRT compared with LCRT among groups of patients with compromised general conditions.…”

Neoadjuvant therapy in rectal cancer: how are we choosing?

“…In our study, clinical node positivity was an independent predictor for receiving LCR over SCR. This is in line with findings of a recent cohort study that demonstrated that patients staged as N1 or N2 were more likely to receive LCR over SCR (OR 5.08, CI 2.51–11.22, P < 0.0001 and OR 8.35, CI 3.35–22.39, P < 0.001, respectively) . However, almost a third of presumed node‐positive patients in our cohort who received neoadjuvant therapy, had SCR rather than LCR, suggesting that it is not the only factor driving decision‐making.…”

Preoperative short-course radiotherapy and long-course radiochemotherapy for locally advanced rectal cancer: Meta-analysis with trial sequential analysis of long-term survival data

“…Based on the inclusion and exclusion criteria, 217 studies were excluded and 21 studies were subjected to a more detailed review. Finally, 11 studies (4 RCTs [ 10 , 13 – 15 ] and 7 non-RCTs [ 28 – 34 ]) with a total of 1984 patients were included in this meta-analysis.…”

“…11 included studies all analyzed OS and DFS, and 10 of them analyzed LR. 4 RCTs [ 10 , 13 – 15 ] out of the 11 studies earned scores of 6 for quality assessment based on the modified Jadad scale, and the 7 non-RCTs [ 28 – 34 ] were scored 4.…”