Impact of donor time to cardiac arrest in lung donation after circulatory death

Qaqish, Robert; Watanabe, Y.; Höetzenecker, Konrad; Yeung, J.C.; Chen, Manyin; Pierre, Andrew; Yasufuku, Kazuhiro; Donahoe, Laura; Perrot, Marc de; Waddell, Tom; Keshavjee, S.; Cypel, Marcelo

doi:10.1016/j.jtcvs.2020.04.181

Cited by 16 publications

(16 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tanaka et al, observed PGD grade 3 at 72 h in 21% in lung recipients whose median cDCD donor age was 59 years 27 . However, we would like to emphasize that PGD rate in our cDCD group is similar to most of previous publications of lungs obtained from cDCD with the traditional RR technique 4,28,31 …”

Section: Discussionsupporting

confidence: 80%

“…Our median cDCD donor age was 55 years, much older than most studies on transplantation of cDCD lungs. 2,3,4,28 In fact, the high percentage of elderly donors (>70 years) in our cDCD group, higher than in the DBD group, shows that this combined method is also safe in marginal lung grafts.…”

Section: It Can Also Damage Abdominal Grafts Due To Low Flow In the Pumpmentioning

confidence: 63%

“…27 However, we would like to emphasize that PGD rate in our cDCD group is similar to most of previous publications of lungs obtained from cDCD with the traditional RR technique. 4,28,31 Prolonged warm ischemia may increase the risk of PGD in the postoperative period. The absence of an international accepted definition of warm ischemia in lungs makes it difficult to compare groups.…”

Section: It Can Also Damage Abdominal Grafts Due To Low Flow In the Pumpmentioning

confidence: 99%

See 2 more Smart Citations

Lung transplantation from controlled donation after circulatory death using simultaneous abdominal normothermic regional perfusion: A single center experience

Cuesta

Ballesteros

Naranjo

et al. 2022

American Journal of Transplantation

View full text Add to dashboard Cite

Lung transplantation (LT) is an established therapy for endstage lung disease in selected patients. However, the shortage of organ donors has led investigators to search for new ways to increase the donor pool, such as the use of extended-criteria donors, donation after circulatory death (DCD), or ex situ lung perfusion. 1Lung transplantation using controlled DCD (cDCD) grafts has been widely accepted worldwide, and outcomes are equivalent to those obtained with donation after brain death (DBD) donors. Over the past decade, reports from several centers and multi-institutional

show abstract

Section: Discussionsupporting

confidence: 80%

Section: It Can Also Damage Abdominal Grafts Due To Low Flow In the Pumpmentioning

confidence: 63%

Section: It Can Also Damage Abdominal Grafts Due To Low Flow In the Pumpmentioning

confidence: 99%

See 1 more Smart Citation

Lung transplantation from controlled donation after circulatory death using simultaneous abdominal normothermic regional perfusion: A single center experience

Cuesta

Ballesteros

Naranjo

et al. 2022

American Journal of Transplantation

View full text Add to dashboard Cite

show abstract

“…Several previous case series described an average total DWIT (considering both DCD-II and -III) between 20–40 min [ 19 ]. However, a recent retrospective analysis of a large DCD cohort did not find a correlation between DWIT and early and late post-LuTx outcomes [ 20 , 21 ]. In Italy, DCD lung donation represents a challenge due to legislative constraints as 20 min of asystole are required to confirm cardiocirculatory death, making rapid retrieval strategies unfeasible.…”

Section: Discussionmentioning

confidence: 99%

Lung Biomolecular Profile and Function of Grafts from Donors after Cardiocirculatory Death with Prolonged Donor Warm Ischemia Time

Gori,

Fumagalli,

Lonati

et al. 2022

JCM

View full text Add to dashboard Cite

The acceptable duration of donor warm ischemia time (DWIT) after cardiocirculatory death (DCD) is still debated. We analyzed the biomolecular profile and function during ex vivo lung perfusion (EVLP) of DCD lungs and their correlation with lung transplantation (LuTx) outcomes. Donor data, procurement times, recipient outcomes, and graft function up to 1 year after LuTx were collected. During EVLP, the parameters of graft function and metabolism, perfusate samples to quantify inflammation, glycocalyx breakdown products, coagulation, and endothelial activation markers were obtained. Data were compared to a cohort of extended-criteria donors after brain death (EC-DBD). Eight DBD and seven DCD grafts transplanted after EVLP were analyzed. DCD’s DWIT was 201 [188;247] minutes. Donors differed only regarding the duration of mechanical ventilation that was longer in the EC-DBD group. No difference was observed in lung graft function during EVLP. At reperfusion, “wash-out” of inflammatory cells and microthrombi was predominant in DCD grafts. Perfusate biomolecular profile demonstrated marked endothelial activation, characterized by the presence of inflammatory mediators and glycocalyx breakdown products both in DCD and EC-DBD grafts. Early graft function after LuTx was similar between DCD and EC-DBD. DCD lungs exposed to prolonged DWIT represent a potential resource for donation if properly preserved and evaluated.

show abstract

“…Prior to the MAID drugs administration, heparin 1000 µ/kg was administered intravenously. The MAID combination of medications leads to virtually immediate cardiac arrest, while cDCD donors do require the interval from withdrawal of life‐sustaining therapies to arrest, which is sometimes longer than 60 min 8,13 . After the confirmation of death, which requires 5 min after the arrest, donors were brought to an operating room.…”

Section: Methodsmentioning

confidence: 99%

Outcomes of lung transplantation from organ donation after medical assistance in dying: First North American experience

Watanabe

Kawashima

Kohno

et al. 2022

American Journal of Transplantation

Self Cite

View full text Add to dashboard Cite

Impact of donor time to cardiac arrest in lung donation after circulatory death

Cited by 16 publications

References 19 publications

Lung transplantation from controlled donation after circulatory death using simultaneous abdominal normothermic regional perfusion: A single center experience

Lung transplantation from controlled donation after circulatory death using simultaneous abdominal normothermic regional perfusion: A single center experience

Lung Biomolecular Profile and Function of Grafts from Donors after Cardiocirculatory Death with Prolonged Donor Warm Ischemia Time

Outcomes of lung transplantation from organ donation after medical assistance in dying: First North American experience

Contact Info

Product

Resources

About