Impact of COVID-19 on Neurological Manifestations: An Overview of Stroke Presentation in Pandemic.

Fatima, Nida; Saqqur, Maher; Shauib, Ashfaq

doi:10.21203/rs.3.rs-36387/v1

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…After exclusion of 14 articles through title and abstract screening, the full texts of 18 articles were assessed. Fourteen studies that did not address our topic of interest 22 23 24 25 26 27 28 29 30 31 32 33 34 35 were excluded. Two studies were excluded because their focuses were on lipoprotein (a) 36 and obesity, 37 respectively.…”

Section: Resultsmentioning

confidence: 99%

The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews

Choi

Kim

Kang

2020

J Lipid Atheroscler

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Objective: The aim of this study was to analyze the available knowledge about the potential association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews. Methods: In this umbrella review (an overview of systematic reviews), we investigated the association between dyslipidemia and COVID-19 severity. A systematic search was performed of 4 main electronic databases (MEDLINE, Embase, Scopus, and the Cochrane Library databases) from inception until August 2020. We evaluated the methodological quality of the included studies using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2 tool and used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence for the outcome. In addition, we evaluated the strengths and limitations of the evidence and the methodological quality of the available studies. Results: Out of 35 articles identified, 2 systematic reviews were included in the umbrella review. A total of 7,951 COVID-19-positive patients were included. According to the AMSTAR 2 criteria and GRADE system, the quality of the included studies was not high. A history of dyslipidemia is likely to be associated with the severity of COVID-19 infection, but the contrary is the case for cholesterol levels at hospitalization. Conclusions: Although existing research on dyslipidemia and COVID-19 is limited, our findings suggest that dyslipidemia may play a role in the severity of COVID-19 infection. More adequately powered studies are needed.

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Section: Resultsmentioning

confidence: 99%

The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews

Choi

Kim

Kang

2020

J Lipid Atheroscler

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“…Special attention and efforts should be applied to prevent and reduce the transmission in susceptible populations, including children, elderly people, and healthcare providers [ 6 ]. Recently, several reports on meningitis, encephalitis, myelitis, and peripheral nerve affection in the context of COVID-19 were published, suggesting that SARS-CoV-2 can directly or indirectly infect structures and functions of the nervous system [ 11 – 20 ]. Coronavirus infections have been associated with the neurological manifestations, viz., febrile seizures, convulsions, change in mental status, and encephalitis [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Neurological manifestations and comorbidity associated with COVID-19: an overview

Kumar

Thakur

2020

Neurol Sci

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First in 2002, severe acute respiratory syndrome coronavirus (SARS-CoV), second in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV), and now the third in the December 2019, emergence of tremendously pathogenic and large-scale epidemic novel coronavirus (SARS-CoV-2) has brought the worst conditions into the human inhabitants of the twenty-first century. The SARS-CoV-2 uses the resembling receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly feasts through the respiratory tract. The ACE2 receptor appearances have been also detected upon glial cells and neurons, which makes them a potential target of SARS-CoV-2 disease (COVID-19). Consequently, cells expressing ACE2, apart from lung and cardiovascular tissue, neurons and glial cells may act as targets and are thus vulnerable to SARS-CoV-2 systemic infection as well as its central nervous system (CNS) comorbidities. Investigation of the neurological manifestations of COVID-19 is a step towards better understanding the SARS-CoV-2 infections, inhibiting the additional spread and treating patients affected by this pandemic. In this concern, more clinical examinations for CNS involvement of SARS-CoV-2 are warranted. In this article, we have reviewed the neurological characteristic features of COVID-19 patients, latent neurotropic mechanisms of SARS-CoV-2 involvement in the comorbidity associated with CNS disorders, and neurological manifestations associated with COVID-19. Therefore, in the perspective of COVID-19 pandemic, clinicians and healthcare workers should be aware of a wide spectrum of neurological manifestations associated with COVID-19 along with their signs and symptoms for initial diagnosis and isolation of the patients.

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“…Finally, 45 systematic reviews met the inclusion criteria and were included in this overview. 11 –55…”

Section: Resultsmentioning

confidence: 99%

The neurological symptoms of COVID-19: a systematic overview of systematic reviews, comparison with other neurological conditions and implications for healthcare services

Wildwing

Holt

2021

Therapeutic Advances in Chronic Disease

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Aims: In response to the rapid spread of COVID-19, this paper provides health professionals with better accessibility to available evidence, summarising findings from a systematic overview of systematic reviews of the neurological symptoms seen in patients with COVID-19. Implications of so-called ‘Long Covid’ on neurological services and primary care and similarities with other neurological disorders are discussed. Methods: Firstly, a systematic overview of current reviews of neurological symptoms of COVID-19 was conducted. Secondly, the implications of these findings are discussed in relation to the potential effect on neurological services and the similarities in the experience of patients with COVID-19 and those with other neurological disorders. A total of 45 systematic reviews were identified within seven databases, published between 11 April 2020 and 15 October 2020, following a search in June 2020, updated on 20 October 2020. Results: The results indicated that COVID-19 exhibits two types of neurological symptoms; life-threatening symptoms such as Guillain–Barre Syndrome (GBS) and encephalitis, and less devastating symptoms such as fatigue and myalgia. Many of these so-called lesser symptoms appear to be emerging as longer-term for some sufferers and have been recently labelled Long Covid. When compared, these less devastating symptoms are very similar to other neurological conditions such as chronic fatigue syndrome (CFS) and functional neurological disorder (FND). Conclusion: Implications for neurological healthcare services in the United Kingdom (UK) may include longer waiting times and a need for more resources (including more qualified health professionals). There is also a possible change-effect on health professionals’ perceptions of other neurological conditions such as CFS and FND. Future research is recommended to explore changes in health professionals’ perceptions of neurological symptoms because of COVID-19.

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Impact of COVID-19 on Neurological Manifestations: An Overview of Stroke Presentation in Pandemic.

Cited by 6 publications

References 20 publications

The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews

The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews

Neurological manifestations and comorbidity associated with COVID-19: an overview

The neurological symptoms of COVID-19: a systematic overview of systematic reviews, comparison with other neurological conditions and implications for healthcare services

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