The global pandemic of COVID-19 has caused serious harm to people's healthy life and the normal operation of society. People have paid more attention to the prevention and control of microbial contamination such as bacteria and viruses. Blocking the spread of disease-causing microorganisms through indirect contact with humans through contaminated surfaces, or avoiding direct contact with them, is the primary way to protect us from harm. Current solutions include designing antibacterial and antiviral surface coatings and developing personal protective equipment made from self-cleaning films or fabrics. In this paper, the work of several widely studied metals, metal oxides, metal organic framework materials, etc. with antibacterial and antiviral functionality is reviewed, their microbial inactivation mechanisms as well as performance are summarized and discussed. In the end, the future perspectives on emerging research directions and challenges in the development of antibacterial and antiviral coatings and films are presented. Keywords inorganic nanomaterials; antimicrobial coatings; self-disinfecting surfaces; self-cleaning films 1 引言 近年来陆续爆发了多种微生物污染引起的传染病, 包括流感 [1] 、COVID-19 [2] 、炭疽 [3] 等. 引起这些流行性 传染病的致病性微生物可以在物体表面存活 2 h 到 9 d [4] , 有的甚至更长时间, 因此极易通过各种途径传播扩 散. 目前已知的传播方式主要有直接接触传播、间接接 触传播(涉及无生命表面的污染)、飞沫传播和空气传 播 [5] . 无论人类通过哪种途径感染了这些病菌, 都会受 到一定危害. 轻者会导致皮肤黏膜等产生过敏反应, 严 重者会导致器官衰竭甚至会带来生命危险. 并且, 大规 模的疫情爆发会给全球经济和社会发展造成巨大损 失 [6][7][8] . 因此, 阻断致病微生物的传播十分重要.研究显示, 在无生命表面涂覆抗菌抗病毒功能涂层 是阻断致病微生物间接传播的有效方案. 通过穿戴个人 防护设备(Personal Protective Equipment, PPE), 如口罩、 手套、护目镜、防护服等来降低与有害微生物直接接触 也是预防人类受到感染的重要方式 [9] . 然而, 一次性 PPE 的大量消耗引起了全世界对 PPE 生产材料资源的 短缺和塑料废弃物污染的严重担忧 [10][11][12][13] . 更紧迫的问题 是, 病原体污染的 PPE 废物不当处置会增加交叉感染的 风险. 实现防护材料和抗菌抗病毒涂层的自消毒和可重 复使用是目前社会所面临的严峻挑战.纳米材料是一类粒径在 1~100 nm 范围内, 微观结 构中至少有一个相的材料. 由于平均尺寸小、表面原子 数量多、比表面积大、表面能高等特征, 其在不同应用 场合中均有十分出色的表现 [14] . 由于其固有的抗病原 体特性以及一些光活性产物和生物策略(包括益生菌或 生物表面活性剂)产生的对细菌、真菌和病毒等微生物 有效灭活作用, 纳米材料已经越来越多地成为医疗环境