Impact of Cigarette Smoking on Papaverine-Induced Erection

Glina, Sidney; Reichelt, A; Leão, Pedro Puech; Reis, J M

doi:10.1016/s0022-5347(17)41708-3

Cited by 32 publications

(12 citation statements)

References 4 publications

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“…For example, cigarette smoking and toxic nicotine particles can inhibit smooth muscle relaxation of erectile tissue, thereby blocking the penile erection response. 22,23 One might propose that there exists a continuum, whereby mildamoderate venous leak leads to severe venous leak which leads to arteriogenic impotence, accounting for the similarly low cavernosal oxygen tension values in groups 1 and 2b. Alternatively, it may well be that our use of Doppler ultrasound may not have the degree of sensitivity needed to detect arterial lesions.…”

Section: Discussionmentioning

confidence: 99%

Vasculogenic impotence and cavernosal oxygen tension

Strohl

et al. 2000

Int J Impot Res

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Aims of this study: To determine the associations, if any, of cavernosal oxygen tension with vasculogenic impotence. Materials and Methods: We evaluated penile cavernosal blood gas levels in men with suspected vasculogenic impotence during penile duplex ultrasonography andaor dynamic infusion cavernosometry and cavernosography (DICC). Patients with suspected impotence were evaluated from 1992 ± 1996. Patient ages ranged from 24 ± 75 y (mean 48 y). Eighteen men had arteriogenic impotence diagnosed by abnormal penile duplex ultrasound after injection of a vasoactive agent, and 23 men had venous leakage diagnosed by DICC. Results: Eighteen men with arteriogenic impotence had the following mean blood gas values: pH 7.38 AE 0.01, PCO2 45.50 AE 0.94, PO2 65.17 AE 2.16. Twenty-three men with venogenic (venous leak) impotence had the following mean cavernosal blood gas values: pH 7.41 AE 0.01, PCO2 42.26 AE 0.83, PO2 74.17 AE 2.51. The differences in PO2 were signi®cant (P`0.05). A subgroup of men with severe venous leakage had PO2 values that were similar to the low arterial PO2 values. Conclusion: The low PO2 in patients with arteriogenic impotence, and the subset of men with severe venous leak impotence, support a global concept of low cavernosal PO2 as a mechanism for both arteriogenic and venogenic impotence.

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Section: Discussionmentioning

confidence: 99%

Vasculogenic impotence and cavernosal oxygen tension

Strohl

et al. 2000

Int J Impot Res

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“…Nicotine infusion into dogs results in inhibition of cavemosal nerve stimulation-induced erections (Jeuneman et al 1987). Smoking 2 cigarettes is sufficient to inhibit penile erections induced by an intracorporeal injection of a low dose of papaverine (Glina et al 1988). Thus, tobacco smoking appears to be a potent cause of impotence.…”

Section: Drug-induced Impotencementioning

confidence: 99%

Impotence in Elderly Men

Morley

Kaiser

1992

Drugs & Aging

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Impotence is a highly prevalent condition occurring in 10 million American men over the age of 18 years. Alterations in vascular supply, hormonal changes with age, neurological dysfunction and the use of a variety of medications may combine and contribute to impotence. Impotence should not be considered a normal part of the aging process. Careful attention to evaluation for the aetiology of impotence will lead to making appropriate therapeutic choices.

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“…Passive smoking also had a significant adverse effect on ED [9]. Smoking may cause ED by several mechanisms, including impairing intrapenile blood flow [29,30]. The link between smoking and ED is important since it may motivate some smokers to quit [29,31].…”

Section: Introductionmentioning

confidence: 99%

Dyslipidemia as a Risk Factor for Erectile Dysfunction

Vrentzos¹,

Paraskevas²,

Mikhailidis

2007

CMC

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Erectile dysfunction (ED) is a common condition with a significant effect on quality of life. The prevalence of ED increases with age and other risk factors (hypertension, diabetes, smoking, coronary heart disease, dyslipidemia and depression). Nitric oxide (NO) activity is adversely affected, in penile and vascular tissue, by these risk factors. Endothelial dysfunction and a reduced generation or bioavailability of NO have emerged as major pathophysiological mechanisms in ED. Hyperlipidemia may impair erectile function by affecting endothelial and smooth muscle cells of the penis. Oxidized low-density lipoprotein is a causative factor for the impaired relaxation response of the corpus cavernosum. Elevated serum cholesterol and reduced high density lipoprotein cholesterol levels are associated with an increased risk of ED. It follows that treating dyslipidemia could have a beneficial effect on ED. Phosphodiesterase type 5 inhibitors are now considered as first line treatment for ED. There is evidence that statins improve responses to these drugs. ED is considered as a warning sign of silent or early vascular disease. The use of statins may be beneficial in these patients.

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Impact of Cigarette Smoking on Papaverine-Induced Erection

Cited by 32 publications

References 4 publications

Vasculogenic impotence and cavernosal oxygen tension

Vasculogenic impotence and cavernosal oxygen tension

Impotence in Elderly Men

Dyslipidemia as a Risk Factor for Erectile Dysfunction

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