2016
DOI: 10.18632/aging.101013
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Abstract: Telomere length, a marker of biological aging, has been associated with cardiovascular disease (CVD). Increased arterial stiffness, an indicator of arterial aging, predicts adverse CVD outcomes. However, the relationship between telomere length and arterial stiffness is less well studied. Here we examined the cross-sectional association between leukocyte telomere length (LTL) and arterial stiffness in 2,165 American Indians in the Strong Heart Family Study (SHFS). LTL was measured by qPCR. Arterial stiffness w… Show more

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Cited by 11 publications
(10 citation statements)
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References 49 publications
(67 reference statements)
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“… 76 Furthermore, substantial evidence has demonstrated that telomere shortening has been linked with greater risk of obesity 77 and cardiovascular disease. 78 In particular, a cohort study conducted on 7,008 U.S. residents suggested that a unit increase in percent body fat, waist circumference (cm) and body mass index (kg/m2) contributed, respectively, to a 0.01%, 0.09% and 0.2% decrease in leukocyte telomere length (T/S ratio), indicating that life course adiposity dynamics are the determinant of telomere shortening. 77 Also, the Strong Heart Family Study sheds light on the potential role of leukocyte telomere length in the prediction of adverse cardiovascular disease outcomes.…”
Section: Potential Role Of Rap1 In Diabetic Cardiomyopathymentioning
confidence: 99%
See 2 more Smart Citations
“… 76 Furthermore, substantial evidence has demonstrated that telomere shortening has been linked with greater risk of obesity 77 and cardiovascular disease. 78 In particular, a cohort study conducted on 7,008 U.S. residents suggested that a unit increase in percent body fat, waist circumference (cm) and body mass index (kg/m2) contributed, respectively, to a 0.01%, 0.09% and 0.2% decrease in leukocyte telomere length (T/S ratio), indicating that life course adiposity dynamics are the determinant of telomere shortening. 77 Also, the Strong Heart Family Study sheds light on the potential role of leukocyte telomere length in the prediction of adverse cardiovascular disease outcomes.…”
Section: Potential Role Of Rap1 In Diabetic Cardiomyopathymentioning
confidence: 99%
“… 77 Also, the Strong Heart Family Study sheds light on the potential role of leukocyte telomere length in the prediction of adverse cardiovascular disease outcomes. 78 It was observed that longer leukocyte telomere length was significantly linked with reduced arterial stiffness. 78 In another observational cohort study on 257 kidney donors for transplantation provides evidence for the close association between shorter telomere length in peripheral blood leukocytes and kidney tissues and intrarenal arteriosclerosis, independent of cardiovascular risk factors.…”
Section: Potential Role Of Rap1 In Diabetic Cardiomyopathymentioning
confidence: 99%
See 1 more Smart Citation
“…Shorter telomere length has been associated with various age‐related diseases, including cardiovascular disease (CVD) , obesity , diabetes and cancer . Among American Indians participating in the Strong Heart Study (SHS), our group has recently reported associations of leukocyte telomere length with incident diabetes , onset and progression of carotid atherosclerosis , obesity , arterial aging and life simple 7 factors .…”
Section: Introductionmentioning
confidence: 99%
“…Shorter leukocyte telomere length (LTL) has been associated with a wide range of aging-related disorders, such as diabetes, cardiovascular disease, and cancer [913]. Among American Indians participating in the Strong Heart Family Study (SHFS), our group has also reported associations of shorter LTL with diabetes [14], carotid atherosclerosis [15], obesity [16], and arterial aging [17]. …”
Section: Introductionmentioning
confidence: 99%