Impact of baseline telomere length on survival and chemotherapy related toxicity in breast cancer patients receiving (neo)adjuvant anthracycline containing chemotherapy

Hatse, Sigrid; Serena, Marta; Vulsteke, Christof; Punie, Kevin; Neven, Patrick; Smeets, Ann; Laenen, Annouschka; Wildiers, Hans

doi:10.1016/j.tranon.2022.101551

Cited by 2 publications

(1 citation statement)

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“…Among the cellular factors that correlate with aging, one of the most remarkable is TL. Thus, TL has been established as a useful and easily measurable marker by RT-qPCR [ 9 , 10 , 11 , 12 ], although there are other approaches for its quantification, such as terminal restriction fragment (TRF) length measurement by Southern blot [ 13 , 14 ]. In this regard, a study on germline telomere shortening by Lisa Boardman et al showed that longer telomeres increased the risk of developing EOCRC, whereas shorter telomeres were associated with late-onset CRC [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Telomere Length as a New Risk Marker of Early-Onset Colorectal Cancer

Martel-Martel

Corchete

Martí

et al. 2023

IJMS

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Early-onset colorectal cancer (EOCRC; age younger than 50 years) incidence has been steadily increasing in recent decades worldwide. The need for new biomarkers for EOCRC prevention strategies is undeniable. In this study, we aimed to explore whether an aging factor, such as telomere length (TL), could be a useful tool in EOCRC screening. The absolute leukocyte TL from 87 microsatellite stable EOCRC patients and 109 healthy controls (HC) with the same range of age, was quantified by Real Time Quantitative PCR (RT-qPCR). Then, leukocyte whole-exome sequencing (WES) was performed to study the status of the genes involved in TL maintenance (hTERT, TERC, DKC1, TERF1, TERF2, TERF2IP, TINF2, ACD, and POT1) in 70 sporadic EOCRC cases from the original cohort. We observed that TL was significantly shorter in EOCRC patients than in healthy individuals (EOCRC mean: 122 kb vs. HC mean: 296 kb; p < 0.001), suggesting that telomeric shortening could be associated with EOCRC susceptibility. In addition, we found a significant association between several SNPs of hTERT (rs79662648), POT1 (rs76436625, rs10263573, rs3815221, rs7794637, rs7784168, rs4383910, and rs7782354), TERF2 (rs251796 and rs344152214), and TERF2IP (rs7205764) genes and the risk of developing EOCRC. We consider that the measurement of germline TL and the status analysis of telomere maintenance related genes polymorphisms at early ages could be non-invasive methods that could facilitate the early identification of individuals at risk of developing EOCRC.

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