Impact of Arterial CO₂Retention in Patients With Moderate or Severe ARDS

Abstract

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Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study

“…The potential mechanisms behind this could be attributed to the fact that the blockage or overdistention of alveoli in patients with hypercapnia could cause the instability of pulmonary units and an imbalance in the ventilation/blood flow ratio [74]. Further studies confirmed that hypercapnia was associated with mortality and that extracorporeal CO 2 removal treatment could correct hypercapnic acidosis, reduce ventilation days and facilitate pulmonary-protective ventilation [42,[75][76][77]. Therefore, strategies aimed at lowering the OSI value could potentially provide greater benefits to patients with hypercapnia.…”

“…net) [36][37][38]. We identified 21 covariates for further analysis based on literature review, our priori knowledge and the minimally sufficient adjustment set, including demographics [39,40] (age, gender and ethnicity), BMI [41], PaCO 2 [42], hemoglobin [43], comorbidities (ARDS, COPD, CKD, AKI, malignancy, HF and diabetes) [44][45][46][47][48], ventilation parameters (PEEP, plateau pressure, tidal volume, OSI at baseline) [49], APS-III score and treatment (dialysis, NMBAs and vasopressor therapy) [50][51][52].…”

Role of RIPK1 in the pathogenesis of acute respiratory distress syndrome

“…(Gorman et al, 2022). Besides, stage 6 also presents CO 2 retention lowering the pH level of the patient and adding more deleterious outcomes for ARDS (Peschel et al, 2021;Maamar et al, 2023).…”

“…The combination of cellular debris in the fluid and atelectasis renders it impossible for the oxygen to get into the capillary membrane in stage 5. In contrast, stage 6 shows pulmonary tissue fibrosis, which indefinitely restricts the gas exchange between the alveoli and the membrane, as well as carbon dioxide retention in the blood (Ohshimo, 2021;Peschel et al, 2021;Gorman et al, 2022;Maamar et al, 2023).…”