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Cited by 21 publications
(25 citation statements)
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“…We have also shown that the CR-associated upregulation of PGC-1α expression is partially mediated through FGF21 in WAT [29]. CR also upregulates PPARγ expression in WAT [29]. In addition, the expression of PGC-1α is increased as a result of rosiglitazone-induced PPARγ activity in WAT [30].…”
Section: Introductionmentioning
confidence: 52%
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“…We have also shown that the CR-associated upregulation of PGC-1α expression is partially mediated through FGF21 in WAT [29]. CR also upregulates PPARγ expression in WAT [29]. In addition, the expression of PGC-1α is increased as a result of rosiglitazone-induced PPARγ activity in WAT [30].…”
Section: Introductionmentioning
confidence: 52%
“…Moreover, Fgf21 Tg mice live longer than Wd mice and have a similar metabolic phenotype to CR mice [28]. We have also shown that the CR-associated upregulation of PGC-1α expression is partially mediated through FGF21 in WAT [29]. CR also upregulates PPARγ expression in WAT [29].…”
Section: Introductionmentioning
confidence: 57%
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“…CR の有益な効果における GH/IGF-1 シグナ ル CR により血中 GH や,GH 刺激により肝臓など から分泌される IGF-1 が減少する. 26) また前述のよ つである Mipep を介する SIRT3 を 始めとする一部のミトコンドリアマトリクスタンパ ク質の成熟化を伴うことを明らかにした(Fig. 1) . 一般に,加齢に伴い Srebp-1c や PPARg,それに転 写制御される脂肪細胞分化や脂質代謝に係わる遺伝 子発現が減少する.41,42) CR は GH/IGF-1 シグナル 非依存性かつ WAT 選択的な Srebp-1c 発現を介し…”
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