Impact of age on adherence and efficacy of peanut oral‐immunotherapy using a standardized protocol

Zhu, Rongbo; Robertson, Kara; Protudjer, Jennifer L. P.; Macikunas, Andrea Leilani; Kim, Rebecca; Jeimy, Samira; Kim, Harold

doi:10.1111/pai.13447

Cited by 8 publications

(14 citation statements)

References 11 publications

(23 reference statements)

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“… 13 The incidences of systemic reactions requiring epinephrine were 5 in 160 patients (3.1%) and 8 in 52,751 peanut Ped-OIT doses (0.015%); whether epinephrine was administered at home or at the clinic was not reported. 13 No patient mortalities were reported in either of these studies.…”

Section: Resultsmentioning

confidence: 98%

“… 12 Similarly, a multicenter study collaborating between community and academic allergists in South-Western Ontario studied 160 patients between the ages of 1 and 17 years who were treated with peanut Ped-OIT between 2016 and 2020. 13 Over a period of 14 months, the patients received monthly incremental increases in peanut protein. 13 Of the 160 patients, 129 completed peanut Ped-OIT, reaching a maintenance dose of 250 mg of peanut protein, and 31 patients (19%) discontinued peanut Ped-OIT because of side effects.…”

Section: Resultsmentioning

confidence: 99%

“… 13 Over a period of 14 months, the patients received monthly incremental increases in peanut protein. 13 Of the 160 patients, 129 completed peanut Ped-OIT, reaching a maintenance dose of 250 mg of peanut protein, and 31 patients (19%) discontinued peanut Ped-OIT because of side effects. 13 The incidences of systemic reactions requiring epinephrine were 5 in 160 patients (3.1%) and 8 in 52,751 peanut Ped-OIT doses (0.015%); whether epinephrine was administered at home or at the clinic was not reported.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Comparing the risk of anaphylaxis requiring epinephrine in oral immunotherapy and subcutaneous immunotherapy: A review of recent Canadian real-world literature

Kovaltchouk

Jeimy

Soller

et al. 2023

Journal of Allergy and Clinical Immunology: Global

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Comparing the risk of anaphylaxis requiring epinephrine in oral immunotherapy and subcutaneous immunotherapy: A review of recent Canadian real-world literature

Kovaltchouk

Jeimy

Soller

et al. 2023

Journal of Allergy and Clinical Immunology: Global

Self Cite

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“…Findings from other studies suggest that a younger age is associated with better treatment outcome and less adverse reactions, but these studies focused on peanut OIT only, and no adult patients were included. 35,36 In the current study, we examined the results of an OIT program being conducted over a decade and found 96 adults who completed OIT for various foods. The total rate of full desensitization was 61.5%.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of food allergy oral immunotherapy in adults

Epstein‐Rigbi

Levy

Nachshon

et al. 2022

Allergy

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Background Oral immunotherapy (OIT) is an emerging method for treating food allergy in children. However, data regarding adults undergoing this process are lacking. Methods We retrospectively analyzed the medical records of patients with food allergy aged ≥17 years who completed OIT treatment between April 2010 and December 2020 at Shamir Medical Center. Data were compared with that of children aged 4 to <11 years and adolescents aged ≥11 to 17 treated during the same time period. Results A total of 96 adults at a median age of 22.3 years who underwent OIT for milk (n = 53), peanut (n = 18), sesame (n = 7), egg (n = 5), and tree nuts (n = 13) were analyzed and compared with 1299 children and 309 adolescents. Adults experienced more adverse reactions requiring injectable epinephrine, both during in‐clinic up‐dosing (49% vs. 15.9% and 26.5% for children and adolescents, respectively, p < 0.0001) and during home treatment (22.9% vs. 12.4%, p = 0.007 for children, and 17.5%, p = 0.23 for adolescents). Most adults (61.5%) were fully desensitized, but the rates of full desensitization were significantly lower than children (73.4%, p = 0.013). Significantly more adults (28.3%) undergoing milk OIT failed treatment than children (14.3%, p = 0.015) and adolescents (14.1%, p = 0.022), while failure rates in adults undergoing OIT for other foods were low (9.3%) and comparable with children and adolescents. Conclusions OIT is successful in desensitizing most adults with IgE‐mediated food allergy. Adults undergoing milk OIT are at increased risk for severe reactions and for OIT failure while failure rates in adults undergoing OIT for other foods are low.

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“…The time before an event of stroke mortality occurred was slowed down among men who drank milk regularly. [ 3 ] Also in the aspect of healthy food, Zhu et al [ 4 ] have demonstrated that their secondary analysis showed that long-term consumption of specific healthy plant foods including nuts, fruits, and vegetables improved weight management and cardiometabolic health, whereas adherence to an overall plant-based diets benefited weight management only, supporting the hypothesis that specific components in plant-based diets are important as well. As a good habit in a high-risk group, Alehagen et al [ 5 ] have reported the relationship between D-dimer and a dietary supplement consisting of selenium and coenzyme Q10 in an elderly community-living population.…”

mentioning

confidence: 99%