Impact of advanced maternal age on maternal and neonatal outcomes in preterm birth

Lü, Lin; Li, Jianhua; Dai, Xiaofeng; Wei, Juanbing; Hu, Jifen

doi:10.5603/gp.a2021.0224

Cited by 12 publications

(10 citation statements)

References 27 publications

(34 reference statements)

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“…From the medical point of view, the risk of miscar-riage increases with age, which is associated with a declining number and quality of egg cells. Advanced maternal age was a risk factor for adverse pregnancy outcomes as well [35]. On the other hand, from the perspective of developmental psychology, a woman is aware of the inevitability of the passage of time and, consequently, has a lesser ability to fulfil the parental role, which may have a negative impact on sexual activity.…”

Section: Discussionmentioning

confidence: 99%

Sexual quality of life and female sexual function in women after fetal death

Białek

Szwabowicz²,

Świercz³

2022

Ginekol Pol

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Objectives: Pregnancy loss is associated with distress which can have a significant emotional impact on women and their spouses including a lower sexual quality of life and sexual dysfunction. The present study aimed to assess sexual quality of life and sexual function in women after fetal death. Material and methods:A total of 110 women with a history of pregnancy loss hospitalized in the Clinic of Obstetrics and Gynecology were included. In order to evaluate the sexual quality of life and sexual functions the standardized questionnaires -the Sexual Quality of Life (SQoL-F) and Female Sexual Function Index (FSFI), respectively were used.Results: Women declared a lower sexual quality of life. Most of them (52.73%) were at a risk of sexual dysfunction in the areas of desire (4.15 ± 1.21) and orgasm (3.82 ± 1.48). The older the age and length of the relationship was (p = 0.002; r = -0.298) the worse the sexual quality of life (p < 0.001) and sexual function were (p < 0.05). The sexual quality of life (p < 0.001) and sexual function in the area of desire (p = 0.001), arousal (p = 0.001) and orgasm (p < 0.001) were significantly better in the women who have experienced one pregnancy loss than in those with more than one pregnancy loss. Sexual function was better in women who did not plan to have a pregnancy. The week in which the pregnancy was lost and the fact of having other children have not been statistically significant. Conclusions:The sexual quality of life and female sexual function in women after an experience of fetal death were less satisfying.

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Section: Discussionmentioning

confidence: 99%

Sexual quality of life and female sexual function in women after fetal death

Białek

Szwabowicz²,

Świercz³

2022

Ginekol Pol

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“…Publication bias was investigated quantitatively using the Begg's test and publication bias was considered present if p > 0.05. 37 To obtain the p-values, a two-tailed test was used. The statistical analysis and graphs were presented with Reviewer Manager v. 5.3 and jamovi software v. 2.3 (https://www.…”

Section: Statistical Analysesmentioning

confidence: 99%

Meta-analysis to assess the role of maternal characteristics

Wang

Zhang

2023

Adv Clin Exp Med

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Background. Postpartum hemorrhage (PPH) is a serious condition that can lead to several complications. Many different factors precipitate PPH.Objectives. To assess the role and impact of different factors such as body mass index (BMI), age, hypertension, parity, and embryo transfer on PPH. Materials and methods.Thirty-one studies have been included in the current meta-analysis. The outcomes of these studies were analyzed using a random-effects model and it was used to calculate the mean difference (MD) with 95% confidence interval (95% CI) in order to quantify the impact of different risk factors on PPH. Results.Regarding the maternal age, older subjects (≥35 years) showed a significantly higher incidence of PPH (MD = 1. 15, 95% CI: 1.03-1.27, p = 0.01). On the other hand, BMI had no impact on the incidence of PPH (MD = 0.76, 95% CI: 0.26-2.24, p = 0.62). At the same time, primiparous subjects, those with hypertension and those in whom frozen-thawed embryo transfer (FTET) was performed showed a significantly higher PPH incidence (

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“…Specific patient characteristics, such as age 35 years or older, higher BMI, no insulin use, and so on, can increase the incidence of GDM (10,11). Moreover, the positive association between maternal age and preterm delivery in GDM remained significant, even after adjusting for relevant confounders (12). It has also been reported that maternal obesity was related to an increased risk of preterm delivery, but obese women with diabetes had an increased risk of preterm delivery, suggesting that blood glucose also plays a role while BMI affects preterm delivery (13).…”

Section: Introductionmentioning

confidence: 98%

Development and validation of nomogram for the prediction of preterm delivery based on patient characteristics and circulating inflammatory cells in patients with gestational diabetes mellitus

Huang¹,

Cai²,

Zhang³

et al. 2023

Ann Transl Med

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Background The incidence of preterm delivery (<37 weeks’ gestation) is increased due to gestational diabetes mellitus (GDM). The preterm delivery is the leading cause of death in children. If potential preterm delivery can be diagnosed early and then prevented, adverse pregnancy outcomes can be improved. Therefore, effective methods are needed for early prediction of preterm delivery in women with GDM. Methods Patients with GDM defined as the presence of at least 1 plasma glucose abnormality at 24–28 weeks of pregnancy [fasting plasma glucose ≥5.1 mmol/L, 60-min ≥10.0 mmol/L, 120-min ≥8.5 mmol/L by 75 g oral glucose tolerance test (OGTT)] from the First Affiliated Hospital of Wenzhou Medical University were enrolled. The data (564 patients) recorded from January 2017 to June 2020 were named the training cohort, and the data (242 patients) obtained from patients with GDM, from July 2020 to January 2022, were named the validation cohort. Mann-Whitney U test and chi-square test were used to compare the skewed distributed and categorical data, respectively. According to the results of univariate logistic regression analysis, the multivariate logistic regression model was developed in the training cohort. Then, the nomogram was established. The validation of the nomogram was conducted on the training and validation cohort. Results No significant differences in baseline characteristics were detected between the 2 cohorts (all P>0.05). The multivariate analysis suggested that maternal age, insulin use, NLR, and monocyte count were the independent predictors of preterm delivery. A nomogram for predicting the probability of preterm delivery was developed. The model suggested good discrimination [areas under the curve (AUC) =0.885, 95% confidence interval (95% CI): 0.855–0.910, sensitivity =83.0%, specificity =83.1% in the training cohort; AUC =0.919, 95% CI: 0.858–0.980, sensitivity =90.6%, specificity =84.8% in the validation cohort] and good calibration [Hosmer-Lemeshow (HL) test: χ 2 =3.618, P=0.306 in the training cohort; χ 2 =6.012, P=0.111 in the validation cohort]. Conclusions The visual nomogram model appears to be a reliable approach for the prediction of preterm delivery, allowing clinicians to take timely measures to prevent the occurrence of preterm delivery in women with GDM at the time of GDM diagnosis, and deserves further investigation.

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Impact of advanced maternal age on maternal and neonatal outcomes in preterm birth

Abstract: Objectives:The aim of this study was to investigate the influence of advanced maternal age on the maternal and neonatal outcomes of preterm pregnancies.

Cited by 12 publications

References 27 publications

Sexual quality of life and female sexual function in women after fetal death

Sexual quality of life and female sexual function in women after fetal death

Meta-analysis to assess the role of maternal characteristics

Development and validation of nomogram for the prediction of preterm delivery based on patient characteristics and circulating inflammatory cells in patients with gestational diabetes mellitus

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