Impact of a low molecular weight hyaluronic acid derivative on contact lens wettability

Yamasaki, Katsuhide; Drolle, Elizabeth; Nakagawa, Haruki; Hisamura, Ryuji; Ngo, William; Jones, Lyndon

doi:10.1016/j.clae.2020.05.003

Cited by 23 publications

(24 citation statements)

References 52 publications

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“…Tonge's et al [74] study showed that the Etafilcon A lenses did not show significant changes in wettability during the initial 4h wear period. Yamasaki et al [75] investigated the effects of hyaluronic acid and low molecular weight hyaluronic acid on contact lenses. According to these results, HA increases the hydrophilicity of the lens surface.…”

Section: Discussionmentioning

confidence: 99%

Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses—In Vitro Study

Chwalik-Pilszyk

Wiśniewska

2022

Materials

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This study attempts to evaluate the effect of incubation in selected ophthalmic fluids on contact lenses (Etafilcon A, Omafilcon A, Narafilcon A, Senofilcon A). Four research groups differing in the incubation environment were created: (1) initial state, (2) contact lens solution (CLS), (3) contact lens solution and eye drops (ED) and (4) eye drops. Dehydration by gravimetric method and the contact angle (CA) by the sessile drop method were tested. The surface free energy (SFE) was also calculated with the use of several methods: Owens–Wendt, Wu, Neumann, and Neumann–Kwok. The greatest changes in the dehydration profile were observed for contact lenses incubated in ED. The most noticeable changes in CA values were observed for contact lenses incubated in ED, in which it was not possible to settle water drop after incubation. On the basis of SFE analysis, higher values were found for hydrogel contact lenses, e.g., according to the Owens–Wendt method, they ranged from 54.45 ± 6.56 mJ/m2 to 58.09 ± 4.86 mJ/m2, while in the case of silicone-hydrogel contact lenses, they ranged from 32.86 ± 3.47 mJ/m2 to 35.33 ± 6.56 mJ/m2. Incubation in all tested environments decreased the SFE values, but the differences were in most cases statistically insignificant. Calculating the SFE may be a useful method as it can be used to estimate the possibility of bacteria adhering to contact lens surfaces.

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Section: Discussionmentioning

confidence: 99%

Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses—In Vitro Study

Chwalik-Pilszyk

Wiśniewska

2022

Materials

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“…By providing enhanced eye lubrication, HA also shows the potential to improve the hydration property of the contact lens and a low MW HA derivative solution has recently been proposed to improve their hydrophilicity. Indeed, it was found that it is able to prolong its wettability over time more effectively than other agents in a comparative study [ 67 ].…”

Section: Medical Applications Of Ha and Its Derivativesmentioning

confidence: 99%

Hyaluronic Acid: Redefining Its Role

Abatangelo

Vindigni

Avruscio

et al. 2020

Cells

282

166

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The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has promoted new research impetus for biologists and, the clinical interest in several fields of medicine, such as ophthalmology, articular pathologies, cutaneous repair, skin remodeling, vascular prosthesis, adipose tissue engineering, nerve reconstruction and cancer therapy. In addition, the great potential of HA in medicine has stimulated the interest of pharmaceutical companies which, by means of new technologies can produce HA and several new derivatives in order to increase both the residence time in a variety of human tissues and the anti-inflammatory properties. Minor chemical modifications of the molecule, such as the esterification with benzyl alcohol (Hyaff-11® biomaterials), have made possible the production of water-insoluble polymers that have been manufactured in various forms: membranes, gauzes, nonwoven meshes, gels, tubes. All these biomaterials are used as wound-covering, anti-adhesive devices and as scaffolds for tissue engineering, such as epidermis, dermis, micro-vascularized skin, cartilage and bone. In this review, the essential biological functions of HA and the applications of its derivatives for pharmaceutical and tissue regeneration purposes are reviewed.

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“…HA exhibits good versatility in application. Because it retains water well, it can be employed to increase tear film stability to treat dry eye disease [ 34 ]; it can be added to contact lens during production [ 35 ] and contact lens care solutions [ 36 ] to increase comfort; and it can be used in skin care products [ 37 ] or added to health food to reduce dry skin [ 38 , 39 ]. Due to its high biocompatibility, HA can enhance tissue growth to heal wounds when combined with receptors on the cell surface [ 13 ] or form dermal fillers to improve wrinkles [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Applications of Hyaluronic Acid in Ophthalmology and Contact Lenses

et al. 2021

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Hyaluronic acid (HA) is a glycosaminoglycan that was first isolated and identified from the vitreous body of a bull’s eye. HA is ubiquitous in the soft connective tissues of animals and therefore has high tissue compatibility for use in medication. Because of HA’s biological safety and water retention properties, it has many ophthalmology-related applications, such as in intravitreal injection, dry eye treatment, and contact lenses. Due to its broad range of applications, the identification and quantification of HA is a critical topic. This review article discusses current methods for analyzing HA. Contact lenses have become a widely used medical device, with HA commonly used as an additive to their production material, surface coating, and multipurpose solution. HA molecules on contact lenses retain moisture and increase the wearer’s comfort. HA absorbed by contact lenses can also gradually release to the anterior segment of the eyes to treat dry eye. This review discusses applications of HA in ophthalmology.

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Impact of a low molecular weight hyaluronic acid derivative on contact lens wettability

Cited by 23 publications

References 52 publications

Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses—In Vitro Study

Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses—In Vitro Study

Hyaluronic Acid: Redefining Its Role

Applications of Hyaluronic Acid in Ophthalmology and Contact Lenses

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