Impact des gonadotrophines chez des patientes traitées pour cancer

Valdelièvre, Constance; Sonigo, Charlotte; Comtet, Marjorie; Simon, Cynthia; Eskenazi, Sarah; Grynberg, Michaël

doi:10.1016/j.bulcan.2016.01.004

Cited by 1 publication

(1 citation statement)

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“…There are several clinical conditions under which FSH expression or signaling via its receptor is increased, resulting in higher circulating levels and ultimately creating a FSH “gain of function” effect. These include ovarian hyperstimulation syndrome (23–26), certain ovarian cancers (27–29), and the recent discovery of non-gonadal FSH actions on bone in transgenic mouse models with elevated human FSH levels (30). GOF effects of FSH in ovaries were also occasionally noted in patients with FSH hypersecreting pituitary adenomas (31).…”

Section: Introductionmentioning

confidence: 99%

Gain–of–Function Genetic Models to Study FSH Action

2019

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Follicle–stimulating hormone (FSH) is a pituitary-derived gonadotropin that plays key roles in male and female reproduction. The physiology and biochemistry of FSH have been extensively studied for many years. Beginning in the early 1990s, coincident with advances in the then emerging transgenic animal technology, and continuing till today, several gain-of-function (GOF) models have been developed to understand FSH homeostasis in a physiological context. Our group and others have generated a number of FSH ligand and receptor GOF mouse models. An FSH GOF model when combined with Fshb null mice provides a powerful genetic rescue platform. In this chapter, we discuss different GOF models for FSH synthesis, secretion and action and describe additional novel genetic models that could be developed in the future to further refine the existing models.

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