Impact and cost-effectiveness of selective human papillomavirus vaccination of men who have sex with men

Lin, Allen; Ong, Koh Jun; Hobbelen, P.H.F.; King, Eleanor M.; Mesher, David; Edmunds, W. John; Sonnenberg, Pam; Gilson, Richard; Bains, Irenjeet; Choi, Yoon Hong; Tanton, Clare; Soldan, Kate; Jit, Mark

doi:10.1093/cid/ciw845

Cited by 37 publications

(63 citation statements)

References 41 publications

(38 reference statements)

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“…HPV-6 and 11 types, which can cause genital warts [4,22], were the most prevalent low-risk HPV types among MSM attending university, and these two types could be protected by both the four-valent and nine-valent HPV vaccines. A previous study found that HPV vaccinations in males were highly effective in largely preventing anogenital warts and anal cancers [23]. The modeling analysis predicted that a vaccination program for males only with a certain coverage (80%) could achieve a reduction of 90% in HPV infections in MSM.…”

Section: Discussionmentioning

confidence: 95%

Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Fan

Ouyang³

et al. 2020

Vaccines

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Men who have sex with men (MSM) attending university are a high-risk population for human papillomavirus (HPV) infection and are a neglected population of HPV vaccination programs in China. To provide evidence for HPV vaccination policies, we conducted this study to examine the prevalence and factors associated with anal HPV infection among MSM attending university in China. A self-administered online questionnaire was conducted to collect information on social demographics and sexual behaviors. A self-collected rectal swab specimen was collected to test for 37 HPV types. A total of 426 participants were tested for HPV. The median age was 20 years. HPV prevalence was 37.5% for any type, 29.8% for nine-valent vaccine types, 24.6% for four-valent vaccine types, 11.5% for HPV-16/18, and 15.7% for HPV-6/11. Men enrolled in a technical diploma, living in Northern China, having more than two sex partners, being bottom or versatile in anal sex, and having a human immunodeficiency virus (HIV) testing history were more likely to have positive anal HPV of any type. Our study found a high prevalence of anal HPV infection among MSM attending university in China, with HPV vaccine-preventable types being the most popular types in this group. Thus, our findings highlight the urgency of promoting HPV vaccination among teenage MSM.

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Section: Discussionmentioning

confidence: 95%

Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Fan

Ouyang³

et al. 2020

Vaccines

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“…Since 2011, the Advisory Committee on Immunization Practice (ACIP) recommended routine vaccination for all males at ages 11‐12 years, through age 21 years for men not previously fully vaccinated, and through age 26 years for MSM and immunocompromised men, including those with HIV infection . Quadrivalent HPV vaccination of MSM was likely reported as an effective and cost‐effective way for reducing the burden of HPV‐related disease in MSM . Particularly, both clinical and economic benefits were reported for quadrivalent HPV vaccine in HIV‐negative MSM as adjunct strategy in the prevention of recurrent high‐grade intraepithelial neoplasia, decreasing the lifetime risk of anal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…[36][37][38] Quadrivalent HPV vaccination of MSM was likely reported as an effective and cost-effective way for reducing the burden of HPV-related disease in MSM. 39,40 Particularly Current evidences support to achieve the target of universal vaccination with a gender-neutral approach by considering both HPV vaccination's clinical effectiveness and economic sustainability. 42,43 Therefore, as MSM should not benefit-even indirectly-from an increasing coverage among females, they represent an important at risk group population to monitor, in which the implementation and the evaluation of effective immunization programmes is required, as well as an increased promotion of knowledge and awareness on HPV prevention among vaccine providers, subjects receiving vaccine and their relatives.…”

Section: Genotype Distribution In Hpv Positive Msmmentioning

confidence: 99%

Prevalence of anal, oral, penile and urethral Human Papillomavirus in HIV infected and HIV uninfected men who have sex with men

Ucciferri

Tamburro

Falasca

et al. 2017

Journal of Medical Virology

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Aims of the study were to evaluate Human Papillomavirus (HPV) and type-specific prevalence in four anatomical sites in HIV infected men who have sex with men (MSM) compared with HIV uninfected MSM. Participants were recruited among the attendees of Infectious Diseases Clinics in Central Italy. A trained medical practitioner collected by interview sociodemographic data and information on medical history, sexual behavior, and drug use. Swabs from anal canal, oral cavity, urethral mucosa, and coronal sulcus were tested for HPV DNA and genotyping. Ninety MSM were enrolled, 45 subjects within each group. Overall, 48.9% MSM were HPV positive and prevalence was higher in HIV infected men (60.0% vs 37.8%, P = 0.035). HPV at multiple anatomic sites occurred in 59.1% MSM, with 34.1% and 22.7% at two and three sites, respectively. Prevalence of anal, coronal sulcus, oral, and urethral HPV was 96.3%, 37%, 21.6%, and 18.5% in HIV infected MSM, and 70.6%, 70.6%, 29.4%, and 23.5% among HIV uninfected. A similar proportion of HIV infected and uninfected MSM (59.2% and 58.8%) carried at least one high-risk genotype. Prevalence of types covered by nonavalent vaccine was 77.8% in HIV infected compared with 82.3% in HIV uninfected MSM. HPV 58 and 16 were mostly detected in HIV positive (43.7% and 31.2%) and negative MSM (50.0% and 40.0%). HPV detection rate underlined the high vulnerability of MSM to acquire multisite infections, characterized by various genotype combinations. Since nonavalent vaccine could have prevented 80% of HPV infections, study findings support the implementation of vaccination programs among MSM.

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“…These data have been used to inform the likely cost-effectiveness and the design of the HPV-MSM programme 8. As this programme implementation starts, GUMCAD data will be well placed to monitor attendances (including potential additional attendances attracted by HPV vaccination), vaccine uptake and course completion.…”

Section: Discussionmentioning

confidence: 99%

Attendance of MSM at Genitourinary Medicine services in England: implications for selective HPV vaccination programme (a short communication)

et al. 2017

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Impact and cost-effectiveness of selective human papillomavirus vaccination of men who have sex with men

Abstract: SummaryOffering human papillomavirus (HPV) vaccination to men who have sex with men up to age 40 years via genitourinary clinics will have a large impact on HPV-related diseases and is likely to be cost-effective.

Cited by 37 publications

References 41 publications

Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Anal Human Papillomavirus Infection among MSM Attending University in China: Implications for Vaccination

Prevalence of anal, oral, penile and urethral Human Papillomavirus in HIV infected and HIV uninfected men who have sex with men

Attendance of MSM at Genitourinary Medicine services in England: implications for selective HPV vaccination programme (a short communication)

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