IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma

Abstract

Sinonasal inverted papilloma (IP) has a propensity for malignant transformation. Although the IP-associated squamous cell carcinoma (SCC) is rare, it has a poor prognosis. To the best of our knowledge, this is the first study to assess IMP3 immunohistochemical (IHC) expression in sinonasal tumors and to compare it to the Ki-67 IHC expression and to other established clinicopathological parameters. A retrospective study was conducted on three groups which consisted of 72 cases of sinonasal IP, 20 age-matched samples of normal respiratory epithelium, and 15 cases of sinonasal SCC associated with IP, which were obtained from the archives of the Pathology Lab of Ain Shams University Specialized and Ain Shams University Hospitals during the period from January 2012 to December 2019. An IHC study was performed to evaluate IMP3 and Ki-67 expression in the three groups, with correlation of IMP3 expression to established clinicopathological parameters of sinonasal SCC on top of IP. Both IMP3 and Ki-67 showed a sharp rise in expression in the sinonasal SCC group. In addition, there were statistically significant differences in expression values between the 3 groups ( P = 0.001 ). Receiver Operating Characteristic (ROC) analysis revealed that IMP3 and Ki-67 could be used to discriminate sinonasal SCC from control and IP lesions, with sensitivity and specificity of 100% and 81.5% for IMP3, respectively, and 100% and 62.5% for Ki-67, respectively. Spearman’s rho revealed that both IMP3 and Ki-67 were significantly related to the lymph node and tumor stages but not to the tumor grade. ROC analysis was performed to select cut-off scores for progression and survival for IMP3, and accordingly, Kaplan-Meier analysis showed correlation between IMP3 and overall survival, local recurrence-free survival, and metastasis-free survival in sinonasal SCC cases at the selected cut-off values. Based on our results, IMP3 could serve as a promising diagnostic, prognostic, and therapeutic marker for IP-associated sinonasal SCC.

Immunohistochemical Expression of IMP3 in Cutaneous Basal Cell Carcinoma

“…IMP3, as already mentioned, is a cytoplasmic marker found in many malignancies [1,2]. Since it shows a tendency towards higher expression in more aggressive neoplasms, it has been considered as a promising prognostic indicator [1][2][3][4][5][6]. However, while the number of studies suggesting the biological and clinical relevance of IMP3 is increasing, there is also a rising number of papers revealing apparent discrepancies with respect to the frequency of expression in some types of cancer [2].…”

“…It is required for the migration of cells forming the roof plate of the neural tube which suggests that IMP3 may play an important role in promoting cell migration [1,2]. Moreover, IMP3 has gained considerable interest as a cancer-associated protein as it has been reported in a variety of human malignancies and has been linked to advanced disease stage and adverse clinical outcomes [1][2][3][4][5][6]. These data indicate that it may represent a valuable prognostic marker in human cancer.…”

İnverted Papillomda PDL-1 Ekspresyonu

“…Recurrence rates of inverted papilloma have been reported in the literature at different rates, ranging from 5% to 45% (27,28) with a value of ≥31, with 100% sensitivity and specificity, is a significant predictive factor for relapse in IP. (29). In addition, the presence of HPV infection, frontal sinus involvement on CT, and the presence of dysplasia in pathological diagnosis are predictive factors for recurrence (8,30,31).…”

Does Loss of Immunohistochemical Expression of Glypican 3 in Oral Squamous Cell Carcinoma Play a Role in the Wnt/β-catenin Signaling Pathway?

“…7 It also acts as a tumor promoter in several cancers such as hepatocellular carcinoma (HCC), lung squamous cell carcinoma (SCC), and cervical cancer cells. [11][12][13][14][15] β-catenin is a cytoplasmic structural protein that is bound in the cell-cell adherens junction and involved in regulating E-cadherin-mediated cell adhesion and the canonical Wnt signaling pathway. 16 Cytoplasmic activity of β-catenin depends on the canonical Wnt signaling pathway status.…”

“…One of the mechanisms of GPC3 downregulation is epigenetic silencing due to hypermethylation of its promoter 7. It also acts as a tumor promoter in several cancers such as hepatocellular carcinoma (HCC), lung squamous cell carcinoma (SCC), and cervical cancer cells 11–15…”