Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Leventhal, Daniel S.; Sokolovska, Anna; Li, Ning; Plescia, Christopher; Kolodziej, Starsha; Gallant, Carey W.; Christmas, Rudy; Gao, Jianrong; James, Michael J.; Abín-Fuentes, Andrés; Momin, Munira; Bergeron, Christopher G; Fisher, Adam; Miller, Paul; West, Kip A.; Lora, José M.

doi:10.1038/s41467-020-16602-0

Cited by 258 publications

(193 citation statements)

References 48 publications

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“… 21 NPs demonstrate beyond reasonable doubt to beautify the ability of the molecules that make up the defensive system by means of calling to action the dendrite cells. 58 NPs also can engineer DCs through specific attachments which produce the signals that activate the defensive mechanism to play and eliminate malignancy.…”

Section: Nanoparticles In Cancer Immunotherapymentioning

confidence: 99%

Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Muluh¹,

Chen²,

Li³

et al. 2021

IJN

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Recently, there has been an incredible increase in research about the abnormal growth of cells (neoplasm), focusing on the management, treatment and preventing reoccurrence. It has been understood that the natural defense system, composed of a variety of immune defensive cells, does not just limit its function in eliminating neoplastic cells, but also controls the growth and spread of tumor cells of different kinds to other parts of the body. Cancer immunotherapy, is a cancer treatment plan that educates the body’s defensive system to forestall, control, and eliminate tumor cells. The effectiveness of immunotherapy is achieved, to its highest efficacy, by the use of nanoparticles (NPs) for precise and timely delivery of immunotherapies to specific targeted neoplasms, with less or no harm to the healthy cells. Immunotherapies have been affirmed in clinical trials as a cancer regimen for various types of cancers, the side effects resulting from imprecise and non-targeted conveyance is well managed with the use of nanoparticles. Nonetheless, we will concentrate on enhancing cancer immunotherapy approaches by the use of nanoparticles for the productivity of antitumor immunity. Nanoparticles will be presented and utilized as an objective immunotherapy delivery system for high exactness and are thus a promising methodology for cancer treatment.

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Section: Nanoparticles In Cancer Immunotherapymentioning

confidence: 99%

Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Muluh¹,

Chen²,

Li³

et al. 2021

IJN

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“…Efforts have been made to attenuate each pathogen to alleviate the toxicity of infection, but attenuation typically dampens the desired immune response 19 . Efforts to use non-pathogenic Escherichia coli strains to boost antitumor immunity also hold promise, but require intratumoral delivery 20,21 .…”

Section: Selecting Staphylococcus Epidermidis Lm087 As the Tumor Antimentioning

confidence: 99%

Eliciting a potent antitumor immune response by expressing tumor antigens in a skin commensal

Chen

Atabakhsh

Dimas

et al. 2021

Preprint

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Immune modulation has become central to treating cancer. However, global immune stimulation is only effective in a subset of patients and can lead to serious complications, including colitis and type I diabetes. Newer modalities like engineered T cells and tumor vaccines are more specific, but they have shown limited efficacy in solid tumors and are difficult to scale. Bacterial strains from the human microbiome can induce antigen-specific T cells to help maintain barrier function. Here, we redirect CD8+ and CD4+ T cells elicited by the skin commensal Staphylococcus epidermidis to recognize tumor cells by expressing tumor-derived antigens in the bacterial cell. S. epidermidis expressing the model antigen ovalbumin (S. epidermidis-OVA) stimulates antigen-specific CD8+ and CD4+ T cells in vitro. The subcellular localization of the antigen skews the response: cell wall-attached OVA preferentially stimulates CD8+ T cells whereas secreted OVA predominantly induces CD4+ T cells. In a syngeneic tumor model (OVA-expressing B16 melanoma), mice colonized topically with S. epidermidis-OVA exhibit a marked reduction in subcutaneous tumor volume compared to mice colonized with S. epidermidis expressing mCherry; this effect is dependent on live bacteria and a combination of CD8+ and CD4+ T cells. S. epidermidis-OVA also reduces tumor burden when tumor cells are injected intravenously (a model of metastasis), demonstrating that the antitumor effect operates in tissues distant from the site of bacterial colonization. S. epidermidis strains expressing neoantigen peptides from the B16 tumor cell line exhibit potent antitumor efficacy without inducing an autoimmune response against melanocytes in healthy tissue. Antigen-expressing colonists are a simple but powerful strategy to elicit a targeted T cell response in the context of cancer and other diseases.

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“…Control of cell morphology, cycle state, and cell-to-cell interactions are some of the key design goals in synthetic biology to develop 'living materials' [1][2][3][4]. As one example, bacteria endospores can be incorporated into materials for revival and functional activation [5].…”

Section: Introductionmentioning

confidence: 99%

Automated classification of bacterial cell sub-populations with convolutional neural networks

2020

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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Cited by 258 publications

References 48 publications

Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System

Eliciting a potent antitumor immune response by expressing tumor antigens in a skin commensal

Automated classification of bacterial cell sub-populations with convolutional neural networks

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