Immunosuppression and Skin Cancer

Otley, Clark C.

doi:10.1001/archderm.138.6.827

Cited by 20 publications

(9 citation statements)

References 6 publications

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Section: Immunosuppressionmentioning

confidence: 96%

“…BCCs are the second most frequent skin malignancy after SCC in this group of patients 21 . Literature data indicate that in the transplant patients skin cancers may have a more aggressive course 21,22 . Moreover, the incidence of nonmelanoma skin cancers (NMSCs) in that group increases with the length of follow‐up after transplantation, estimating that increase to approximately 100‐fold by 5 years after transplantation 23 .…”

Section: Immunosuppressionmentioning

confidence: 97%

“…21 Although we cannot call immunosuppression after transplantations a truly environmental factor, it seems that this kind of treatment could be connected with a very high risk of cutaneous malignancies with the further influence of UV exposure. 21 BCCs are the second most frequent skin malignancy after SCC in this group of patients. 21 Literature data indicate that in the transplant patients skin cancers may have a more aggressive course.…”

Section: Immunosuppression and Uv Radiationmentioning

confidence: 99%

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Environmental Risk Factors Predisposing to the Development of Basal Cell Carcinoma

2004

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BCC is a very complex disease, with many factors influencing its development. Environmental factors are very important for the prevalence of BCC, and most of them can be avoided. The exposure to ultraviolet radiation is undoubtedly of great risk; therefore, the national campaigns against aggressive, seasonal sun exposure, especially in children and adolescents, as well as using sunscreens, are of great value in the fight against BCC development.

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Section: Immunosuppressionmentioning

confidence: 96%

Section: Immunosuppressionmentioning

confidence: 97%

Section: Immunosuppression and Uv Radiationmentioning

confidence: 99%

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Environmental Risk Factors Predisposing to the Development of Basal Cell Carcinoma

2004

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“…Although the small numbers limit the conclusions we can draw from this observation, HIV infection as a risk factor for skin cancer recurrence needs further study. 15,16 …”

Section: Commentmentioning

confidence: 99%

Recurrence After Treatment of Nonmelanoma Skin Cancer

Chren

Torres²,

Stuart³

et al. 2011

Arch Dermatol

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To determine long-term tumor recurrence rates after treatment of primary nonmelanoma skin cancer (NMSC). Data are currently insufficient to permit evidence-based choices among treatments for NMSC.Design: Prospective study of an inception cohort observed for a median of 6.6 years after treatment.Setting: Dermatology clinic at a Veterans Affairs hospital. Care was provided by dermatology resident or attending physicians.Patients: Consecutive sample of all 495 patients with 616 primary NMSCs diagnosed in 1999 and 2000 and treated with electrodessication and curettage (ED&C), excision, or Mohs surgery. Follow-up was available for 608 tumors (99%).Main Outcome Measure: Tumor recurrence, deter-mined by medical record review, with validation by clinical examination. Results:The mean age at diagnosis was 71 years; 97% were men. Overall, 127 tumors were treated with ED&C (20.9%); 309 with excision (50.8%); and 172 with Mohs surgery (28.3%). Over the course of the study, 21 tumors recurred (3.5% [95% confidence interval (CI), 2.2%-5.2%]): 2 after ED&C (1.6% [95% CI, 0.2%-5.6%]), 13 after excision (4.2% [95% CI, 2.2%-7.1%]), and 6 after Mohs surgery (3.5% [95% CI, 1.3%-7.4%]).Conclusions: Recurrence of primary NMSC after treatment occurred in less than 5% of tumors. The recurrence rate after ED&C was lower than expected, and the recurrence rate after Mohs surgery was higher than expected. These findings may be related to the risk for recurrence in the treatment groups.

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“…18, 19 The incidence of basal cell carcinoma (BCC), the most common skin cancer, has been doubling every 14 years. 20 The risk for subsequent BCCs after an initial tumor is substantial, with 44% developing additional lesions within three years.…”

mentioning

confidence: 99%

Basal Cell Carcinoma

Fagundes¹,

Glaser

Johnson

et al. 2012

Arch Gen Psychiatry

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Context Child emotional maltreatment can result in lasting immune dysregulation that may be heightened in the context of more recent life stress. Basal cell carcinoma (BCC) is the most common skin cancer, and the immune system plays a prominent role in tumor appearance and progression. Objective To address relationships among recent severe life events, childhood parental emotional maltreatment, depression, and messenger RNA (mRNA) coding for immune markers associated with BCC tumor progression/regression. Setting University medical center Design We collected information about early parent-child experiences, severe life events in the last year as assessed by the Life Events and Difficulties Schedule (LEDS), depression, and mRNA for immune markers associated with BCC tumor progression/regression from BCC tumor patients. Participants 91 BCC patients (ages 23–92) who had all had a previous BCC tumor. Main Outcome Measures The expression of four BCC tumor mRNA markers (CD25, CD3ε, ICAM-1, and CD68) that have been linked to BCC tumor progression/regression were assessed in BCC tumor biopsies. Results Both maternal and paternal emotional maltreatment interacted with the occurrence of severe life events to predict the local immune response to the tumor (adjusted p=0.009, p=0.03, respectively). Among BCC patients who had experienced a severe life event within the past year, those who were emotionally maltreated by their mothers (p=0.007) or fathers (p=0.02) as children had a poorer immune response to the BCC tumor. Emotional maltreatment was unrelated to BCC immune responses among those who did not experience a severe life event. Depressive symptoms were not associated with the local tumor immune response. Conclusions Troubled early parent-child relationships, in combination with a severe life event in the past year, predicted immune responses to a BCC tumor. The immunoreactivity observed in BCCs and the surrounding stroma reflects an anti-tumor-specific immune response that can be altered by stress.

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Immunosuppression and Skin Cancer

Cited by 20 publications

References 6 publications

Environmental Risk Factors Predisposing to the Development of Basal Cell Carcinoma

Environmental Risk Factors Predisposing to the Development of Basal Cell Carcinoma

Recurrence After Treatment of Nonmelanoma Skin Cancer

Basal Cell Carcinoma

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