2013
DOI: 10.18632/aging.100619
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Abstract: During the past two decades, several interventions have been shown to increase the healthy lifespan of model organisms as evolutionarily distant from each other as yeast, worms, flies and mammals. These anti-aging maneuvers include (but are not limited to) cycles of caloric restriction, physical exercise as well as the administration of multiple, chemically unrelated agents, such as resveratrol, spermidine and various rapamycin-like compounds collectively known as rapalogs. Most, if not all, lifespan-extending… Show more

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Cited by 25 publications
(12 citation statements)
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References 81 publications
(77 reference statements)
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“…The beneficial effects of RSV were originally thought to derive from its antioxidant properties [26]. Moreover, RSV has been shown to possess anti-platelet, anti-cancer and lifespan-extending effects in various experimental models [27,28,29,30]. It has been reported that SIRT1 regulates both inflammatory processes and cholesterol metabolism in macrophages by reducing the uptake of ox-LDL and preventing the formation of macrophage foam cells [31].…”
Section: Discussionmentioning
confidence: 99%
“…The beneficial effects of RSV were originally thought to derive from its antioxidant properties [26]. Moreover, RSV has been shown to possess anti-platelet, anti-cancer and lifespan-extending effects in various experimental models [27,28,29,30]. It has been reported that SIRT1 regulates both inflammatory processes and cholesterol metabolism in macrophages by reducing the uptake of ox-LDL and preventing the formation of macrophage foam cells [31].…”
Section: Discussionmentioning
confidence: 99%
“…Rapamycin was originally isolated from Streptomyces hygroscopicus, which is indigenous in the Easter Islands and was used originally for declining immune response in the case of organ transplantation. However, later its robust immuneenhancing effect was also cleared [105]. Its target is the mammalian target of Rapamycin (mTOR), which is a serin/threonin kinase, encoded by the mTOR gene in men.…”
Section: Pro-immunity and Antiagingmentioning
confidence: 99%
“…HDAC inhibitors were previously reported to exhibit strong anti-inflammatory effects[ 34 - 36 ]. Rapamycin, however, previously viewed as a pure immune suppressant drug, was more recently also shown to mediate strong immune stimulating effects as reviewed in[ 37 , 38 ]. Similarly, a recent study showed that the Class I HDAC inhibitor Entinostat markedly enhanced anti-tumor vaccination[ 39 ].…”
Section: Introductionmentioning
confidence: 99%