Immunophenotypic quantification of M1 and M2 macrophage polarization in radicular cysts of primary and permanent teeth

Bertasso, Amanda Silva; León, Jorge Esquiche; Silva, R A B; Silva, L A B; Queiroz, Alexandra Mussolino de; Pucinelli, Carolina Maschietto; Romualdo, Priscilla Coutinho; Filho, Paulo Nelson

doi:10.1111/iej.13257

Cited by 19 publications

(27 citation statements)

References 38 publications

(50 reference statements)

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“…The higher levels of infiltration of M1-like macrophages in RCs indicate that an aggressive state of RCs could be observed, more proinflammatory cytokines might be secreted to the lesion area, and the activated osteoclasts in the apical region of the affected teeth ( 33 ). In addition, a similar expression profile of macrophages was observed in RCs of both primary and permanent teeth ( 35 ). These studies suggest that macrophages may exhibit different expression phenotypes at different stages of PL progression.…”

Section: The Clinical Implications Of Macrophage Distribution In Peri...mentioning

confidence: 55%

Macrophages in periapical lesions: Potential roles and future directions

Song

Huang

et al. 2022

Front. Immunol.

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Periapical lesions are infectious diseases that occur in the apical region of teeth. They result in the destruction of alveolar bone and are usually accompanied by swelling, pain, and possible systemic impacts. A complex interaction between pathogens and the host immune system determines the development, progression, and outcome of periapical lesions. The lesions, if not treated promptly, may cause resorption of bone tissue, destruction of the periodontal ligament, and loss of the affected teeth, all of which can severely worsen the quality of life of patients, often at considerable economic cost to both patients and medical organizations. Macrophages are a group of heterogeneous cells that have many roles in the development of infections, destruction and reconstruction of bone tissues, and microbe–host interactions. However, the differential and comprehensive polarization of macrophages complicates the understanding of the regulatory mechanism of periapical lesion progression. This report provides a comprehensive review of recent advances in our knowledge of the potential role of macrophages in determining the turnover of human periapical lesions. For example, macrophage differentiation might indicate whether the lesions are stable or progressing while the extent of bacteria invasion could regulate the differentiation and function of macrophages involved in the periapical lesion. In addition, alternative strategies for the treatment of apical periodontitis are discussed.

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Section: The Clinical Implications Of Macrophage Distribution In Peri...mentioning

confidence: 55%

Macrophages in periapical lesions: Potential roles and future directions

Song

Huang

et al. 2022

Front. Immunol.

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“…IL-13 is a prototypical profibrogenic molecule produced by basophils, mast cells, innate lymphoid cells, Th2 cells and M2 macrophages. These findings could help explain why a fibrous stroma is more evident in chronic periapical lesions arising from permanent rather than primary teeth (Lima et al 2011, Bertasso et al 2020.…”

Section: Discussionmentioning

confidence: 96%

“…Through immunohistochemistry, immune cell infiltration (T cells, B cells and macrophages) in chronic periapical lesions arising from primary teeth has been reported (Bolan et al 2008, Bertasso et al 2020). In the current study, the Ig profile of plasma cells in these chronic periapical lesions has been described for the first time.…”

Section: Discussionmentioning

confidence: 99%

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IgG4‐positive plasma cells are more often detected in chronic periapical lesions arising from permanent rather than primary teeth

Polanco¹,

Bertasso²,

Silveira

et al. 2021

Int Endodontic J

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“…В «зону боевых действий» активно мигрируют лейкоциты. Иммунохимические исследования гистопрепаратов подтверждают выраженную М2-поляриза-цию макрофагов в области гранулёмы [1]. Этот фенотип клеток ответственен за демаркацию, ограничение зоны воспаления.…”

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Destructive lesions of apical periodontitis: achievements of fundamental and applied science in modern approaches to solving the problem

Blinova¹,

Rumyantsev²

2021

HMJ

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Destructive lesions of the periodontium are a serious professional challenge for dentists. Along with tooth loss, which requires expensive prosthetics, chronic odontogenic inflammation provokes transient bacteremia and disrupts the homeostasis of the body. This leads to an exacerbation of somatic diseases, the development of allergic reactions and atherosclerotic damage to the walls of blood vessels. Timely diagnosis and prognosis, adequate choice of treatment methods play a key role in providing care to patients with this pathology. Depending on the clinical situation, both conservative and surgical strategies can be successful. The aim of this review is systematization of the scientific facts, which were accumulated over the past 5–10 years and describing the existing regenerative surgical techniques and promising possibilities of conservative treatment of destructive apical periodontal lesions. CONCLUSION: The latest materials for tissue regeneration developed by scientists are promising in complicated clinical cases associated with a significant loss of the bone tissue and spread of the lesion to the neighboring anatomical structures (maxillary sinus, nasal cavity, etc.). However, with the development of ideas of a tooth as of a nanostructured organ, integration of nanoscale particles with antimicrobial properties into the composition of temporary and permanent filling materials, conservative treatment methods also possess great practical potential. A deeper understanding of pathophysiology and microbiology of pathological process of cyst formation creates methodological basis for development by dentists of the novel therapeutic methods of treatment of periapical lesions that are currently regarded as a “sentence” to the invasive intervention – cystectomy, resection of the root apex or removal of the causal tooth. Effective endodontics is the key to sparing and predictable elimination of foci of chronic odontogenic infection that deranges homeostasis of the whole organism. This is a promising field for synthesis of fundamental and clinical knowledge, for international scientific cooperation with the primary aim to improve the quality of Human life.

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Immunophenotypic quantification of M1 and M2 macrophage polarization in radicular cysts of primary and permanent teeth

Abstract: Bertasso AS, L eon JE, Silva RAB, Silva LAB, de Queiroz AM, Pucinelli CM, Romualdo PC, Nelson-Filho P. Immunophenotypic quantification of M1 and M2 macrophage polarization in radicular cysts of primary and permanent teeth.

Cited by 19 publications

References 38 publications

Macrophages in periapical lesions: Potential roles and future directions

Macrophages in periapical lesions: Potential roles and future directions

IgG4‐positive plasma cells are more often detected in chronic periapical lesions arising from permanent rather than primary teeth

Destructive lesions of apical periodontitis: achievements of fundamental and applied science in modern approaches to solving the problem

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