2013
DOI: 10.1007/s10616-013-9663-2 View full text |Buy / Rent full text
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Abstract: Human umbilical cord blood (hUCB) has been the preferred source of stem cells for the treatment of haematological malignancies and genetic disorders. This is primarily due to its non-invasiveness, high accessibility with relative ease of isolation. Still failures do prevail due to its heterogeneity and lesser frequency of MSC identified in UCB. This study, thus, employs a cell enrichment technology to improve its therapeutic efficacy. This was achieved by immunophenotypic comparison of stem cells isolated from… Show more

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“…Due to these shortcomings, alternative sources of MSCs have been extensively researched including MSCs from umbilical cord, fat tissue, and craniofacial tissues . However, such MSCs from adult tissues are heterogeneous and variable among donors, and isolation of homogenous populations of MSCs has been challenging . To overcome these issues, human embryonic stem cell‐derived MSCs (ES‐MSCs) are being used as a possible alternative source for MSCs .…”
Section: Introductionmentioning
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“…Due to these shortcomings, alternative sources of MSCs have been extensively researched including MSCs from umbilical cord, fat tissue, and craniofacial tissues . However, such MSCs from adult tissues are heterogeneous and variable among donors, and isolation of homogenous populations of MSCs has been challenging . To overcome these issues, human embryonic stem cell‐derived MSCs (ES‐MSCs) are being used as a possible alternative source for MSCs .…”
Section: Introductionmentioning
“…Isolated from urine samples, subpopulations of the USCs are characterized by distinct cell morphology, various potential for proliferation and differentiation [ 33 ], similar clone-forming efficiency and high level of CD29 expression [ 34 ]. Also known as Integrin beta 1, an adhesion molecule, the CD29 can bind with a variety of ligands and play an important role in the mobilization, homing, migration and differentiation of stem cells as well as mediation of niche interactions [ [72] , [73] , [74] , [75] , [76] , [77] ]. As a surface marker for the MSCs, CD29 is essential for cell adhesion and recognition in a variety of biological processes including embryogenesis, tissue repair and immune response [ 78 , 79 ].…”
Section: Discussionmentioning