Immunomodulatory effects of chicken soups prepared with the native cage-free chickens and the commercial caged broilers

Li, Zuyue; Li, Yongming; Cai, Zhaoxia; Jin, Guofeng; Ahn, Dong Uk; Huang, Xi

doi:10.1016/j.psj.2022.102053

Cited by 8 publications

(5 citation statements)

References 60 publications

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“…Amino Acid Composition. The total amino acid composition was determined using the method described by Li et al, 18 with some modifications. 50 mg of the sample was hydrolyzed with 10 mL of HCl (6 M) at 110 °C for 24 h. Afterward, the solution was filtered with a 0.22 μm membrane filter and then analyzed using an amino acid automatic analyzer (A300, membra Pure GmbH, Beijing, China).…”

Section: Secondary Structurementioning

confidence: 99%

Identification and Molecular Mechanism of Novel Two-Way Immunomodulatory Peptides from Ovalbumin: In Vitro Cell Experiments, De Novo Sequencing, and Molecular Docking

Li,

Abou-Elsoud,

Chen

et al. 2024

J. Agric. Food Chem.

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The purpose of this study was to identify ovalbumin-derived immunomodulatory peptides by in vitro cell experiments, de novo sequencing, and molecular docking. Ovalbumin hydrolysates were prepared by two enzymes (alkaline protease and papain) individually, sequentially, or simultaneously, respectively. The simultaneous enzymatic hydrolysate (OVAH) had a high degree of hydrolysis (38.12 ± 0.48%) and exhibited immune-enhancing and anti-inflammatory activities. A total of 160 peptides were identified by LC−MS/MS in OVAH. Three novel peptides NVMEERKIK, ADQARELINS, and WEKAFKDE bound to TLR4-MD2 through hydrogen bonds and hydrophobic interactions with high binding affinity and binding energies of −181.40, −178.03, and −168.12 kcal/mol, respectively. These three peptides were synthesized and validated for two-way immunomodulatory activity. NVMEERKIK exhibiting the strongest immunomodulatory activity, increased NO and TNF-α levels by 128.69 and 38.01%, respectively, in normal RAW264.7 cells and reduced NO and TNF-α levels by 27.31 and 39.13%, respectively, in lipopolysaccharideinduced inflammatory RAW264.7 cells. Overall, this study first revealed that ovalbumin could be used as an immunomodulatory source for controlling inflammatory factor secretion.

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Section: Secondary Structurementioning

confidence: 99%

Identification and Molecular Mechanism of Novel Two-Way Immunomodulatory Peptides from Ovalbumin: In Vitro Cell Experiments, De Novo Sequencing, and Molecular Docking

Li,

Abou-Elsoud,

Chen

et al. 2024

J. Agric. Food Chem.

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“…Chicken soup is a dish made by stewing chicken as raw material, which is highly favored by consumers around the world due to its rich nutrition and unique flavor, and has become a popular food ( Qi et al, 2023 ). In traditional Chinese dietary culture, chicken soup is regarded as a tonic product with therapeutic properties, with prevent colds, relieve inflammation, and improve immunity, especially suitable for children, the elderly and the infirm ( Guan et al, 2023 , Li et al, 2022 ). Stewing is a cooking method with prolonged heating, which promotes the release of creatinine, bioactive peptides, flavor peptides, flavor nucleotides, and free amino acids, benefit for the digestion and absorption of chicken meat ( Xiao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Bamboo shoots improve the nutritional and sensory quality, and change flavor composition of chicken soup

Wang,

Wu,

Zhang

et al. 2024

Food Chemistry: X

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“…Unlike commercially farmed chickens confined in cages, backyard poultry offers a unique flavor, richer nutritional profile, and improved immunity (Li et al., 2022). Nevertheless, their free‐range cultivation presents challenges in biosecurity and increased disease risk (Derksen et al., 2018; Tansawai et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

“…As reported, the market for backyard chickens is expanding in China and other developing countries (Zhu et al, 2018). Similarly, countries like the United States and Canada have seen a rise in backyard poultry prevalence (Brochu et al, 2019;Elkhoraibi et al, 2014).Unlike commercially farmed chickens confined in cages, backyard poultry offers a unique flavor, richer nutritional profile, and improved immunity (Li et al, 2022). Nevertheless, their free-range cultivation presents challenges in biosecurity and increased disease risk (Derksen et al, 2018;Tansawai et al, 2019).…”

mentioning

confidence: 99%

Depletion of tilmicosin residue in Gushi chickens following oral administration via drinking water

Zhang,

Qian,

et al. 2023

Vet Pharm & Therapeutics

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This study aimed to examine the depletion of tilmicosin residues in Gushi chickens following the administration at a concentration of 75 mg/L in their drinking water for three consecutive days. Plasma, liver, kidney, lung, muscle, and skin + fat samples were collected from 6 chickens at 6 h, 1, 3, 5, and 7 days after the treatment. Tilmicosin concentrations in the samples were determined using a high‐performance liquid chromatography (HPLC) method. The findings revealed that the highest tilmicosin residues were detected in the liver, followed by the kidney, lung, skin + fat, muscle, and plasma. Notably, at 7 days post‐treatment, no drug residue was detected in all samples except for the liver and kidney. The non‐compartmental model was employed to calculate relevant pharmacokinetic parameters. The elimination half‐lives (t1/2λz) of tilmicosin were as follows, ranked from long to short: skin + fat (45.42 h), liver (44.17 h), kidney (40.06 h), plasma (37.64 h), lung (31.39 h), and muscle (30.05 h). Considering the current residue depletion and the maximum residue limits (MRLs) set by Chinese regulatory authorities, the withdrawal times for tilmicosin were estimated as 18.91, 10.81, and 8.58 days in the kidney, liver, and skin + fat, respectively. A rounded‐up value of 19 days was selected as the conclusive withdrawal time. Furthermore, based on the observed tilmicosin concentrations in plasma and lung, combined with previously reported minimum inhibitory concentration (MIC) values against Mycoplasma gallisepticum, the current dosing regimen was deemed adequate for treating Mycoplasma gallisepticum infections in Gushi chickens.

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Immunomodulatory effects of chicken soups prepared with the native cage-free chickens and the commercial caged broilers

Cited by 8 publications

References 60 publications

Identification and Molecular Mechanism of Novel Two-Way Immunomodulatory Peptides from Ovalbumin: In Vitro Cell Experiments, De Novo Sequencing, and Molecular Docking

Identification and Molecular Mechanism of Novel Two-Way Immunomodulatory Peptides from Ovalbumin: In Vitro Cell Experiments, De Novo Sequencing, and Molecular Docking

Bamboo shoots improve the nutritional and sensory quality, and change flavor composition of chicken soup

Depletion of tilmicosin residue in Gushi chickens following oral administration via drinking water

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