Immunomodulatory Effect of Triphala during Experimentally Induced Noise Stress in Albino Rats

Srikumar, Ramakrishnan; Parthasarathy, Narayanaperumal Jeya; Manikandan, S.; Muthuvel, A.; Rathinam, Rajamani; Sheeladevi, Rathinasamy

doi:10.1248/jhs.53.142

Cited by 8 publications

(9 citation statements)

References 11 publications

(12 reference statements)

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“…Such an increase in IL-4 and a concomitant decrease in IL-2 and IFN-γ on exposure to noise stress has been reported. 41 Our observations revealed that the deviated levels of the IL-4 and IFN-γ in chronically stressed rats were reversed by AC as well as α-asarone treatments while the IL-2 levels, though were markedly increased from the stressed animals, could not be completely reversed.…”

Section: Two Subsets Of T Helper Cells (Th Cells) Namelymentioning

confidence: 53%

Effect of Acorus Calamus Linn. And Its Active Principle on Noise Stress-Induced Changes on Immune System

Subramanian

2012

Int J of Biomed & Adv Res

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Noise is an inevitable everyday stressor in our lives and is detrimental to our immune system. The aim of the present study was to investigate the potential of ethyl acetate extract of Acorus Calamus (AC) and its active component, α-asarone on the noise stress induced changes on immune system of Wistar albino rats. Noise stress of 100dB for 4h/day for 30 days was employed in this study to observe the effect of stress on immune system and the dosage of AC and α-asarone used were 50 mg / Kg b.wt and 9mg/Kg b.wt respectively for 45 days. Sheep red blood cells (5 × 10 9 cells/ml) were used to immunize the animals. Six different groups were used: Control Immunized, AC treated immunized, α-asarone treated immunized, Noise stress immunized, AC treated stress immunized, α-asarone treated stress immunized groups. The immune status was assessed by the serum cytokine levels of IL-2, IL-4, IFN-γ and the CD4, CD8 T cell lymphocyte phenotype in spleen while biochemical markers of oxidative stress-LPO, GSH in spleen and corticosterone in plasma were estimated in the immune challenged animals. Results showed that noise stress significantly increased the lipid peroxidation and corticosterone level with concomitant depletion of GSH in the immunized rats. Noise stress significantly suppressed the CD4 and CD8 T cells in spleen and the cytokines IL2, IFN-γ and enhanced IL4 levels in the serum. The supplementation with AC as well as α-asarone prevents the noise stress induced changes in the antioxidant as well as immune status in rats. This study concludes that AC restores the noise stress induced changes which may be due to its active principle α-asarone.

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Section: Two Subsets Of T Helper Cells (Th Cells) Namelymentioning

confidence: 53%

Effect of Acorus Calamus Linn. And Its Active Principle on Noise Stress-Induced Changes on Immune System

Subramanian

2012

Int J of Biomed & Adv Res

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“…The present observation in noise stressed animal is further correlated with Srikumar et al. [24], where noise stress induced a decrease in FPT with an enhancement in LMI. The decrease in foot pad thickness after stress could be due to the effect of stress on the inflammatory, mediatory and adhesion molecules on the endothelial cell and extra vascular space.…”

Section: Discussionmentioning

confidence: 97%

“…During the experiment, the noise level peaked at 100 dB immediately after the generator was switched on and continued daily for 4 h for 15 days. The controls were also kept in these cages without noise stress exposure [24].…”

Section: Methodsmentioning

confidence: 99%

Effect of Scoparia dulcis on noise stress induced adaptive immunity and cytokine response in immunized Wistar rats

Loganathan

Srinivasan

Wankhar

et al. 2017

Journal of Ayurveda and Integrative Medicine

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BackgroundNoise acts as a stressor and is reported to have impact on individual health depending on nature, type, intensity and perception. Modern medicine has no effective drugs or cure to prevent its consequences. Being an environmental stressor noise cannot be avoided; instead minimizing its exposure or consuming anti-stressor and adaptogens from plants can be considered.ObjectivesThe present study was carried out to evaluate the anti-stressor, adaptogen and immunostimulatory activity of Scoparia dulcis against noise-induced stress in Wistar rat models.Material and methodsNoise stress in rats was created by broadband white noise generator, 100 dB A/4 h daily/15 days and S. dulcis (200 mg/kg b.w.) was administered orally. 8 groups of rats were used consisting of 6 animals each; 4 groups for unimmunized and 4 groups for immunized. For immunization, sheep red blood cells (5 × 109 cells/ml) were injected intraperitoneally.ResultsSub-acute noise exposed rats showed a significant increase in corticosterone and IL-4 levels in both immunized and unimmunized rats whereas lymphocytes, antibody titration, soluble immune complex, IL-4 showed a marked increase with a significant decrease in IL-2, TNF-α, IFN-γ cytokines only in unimmunized rats. Immunized noise exposed rats presented increased leukocyte migration index and decreased foot pad thickness, IL-2, TNF-α, IFN-γ with no changes in the lymphocytes.ConclusionS. dulcis (SD) has normalized and prevented the noise induced changes in cell-mediated and humoral immunity and it could be the presence of anti-stressor and immuno stimulant activity of the plant.

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“…Therefore the herb may cause augmentation of the humoral immune response to sheep red blood cells SRBCs acting as antigens that caused enhanced responsiveness of T and B-lymphocyte subtypes of the immune system thus promoting the anti-body synthesis (Sharififar et al, 2009) in the Wistar albino rats similar to what has been observed in other studies. The increased adhesion of the neutrophils to nylon fibers could be due to the compounds in the herb that may improve the migration of phagocytes such as neutrophils to the foreign body in blood vessels (Guyton and Hall, 2006;Srikumar et al, 2007). The neutrophils represent a multifunctional cell type in innate immunity that contributes to bacterial clearance by recognition, phagocytosis and killing of foreign bodies (Guyton and Hall, 2006;Srikumar et al, 2007), whereas the T and Blymphocytes are involved and responsible for production of antibodies leading to enhancement of immunity (Guyton and Hall, 2006;Srikumar et al, 2007;GarlandScience, 2008;Soehnlein et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…The increased adhesion of the neutrophils to nylon fibers could be due to the compounds in the herb that may improve the migration of phagocytes such as neutrophils to the foreign body in blood vessels (Guyton and Hall, 2006;Srikumar et al, 2007). The neutrophils represent a multifunctional cell type in innate immunity that contributes to bacterial clearance by recognition, phagocytosis and killing of foreign bodies (Guyton and Hall, 2006;Srikumar et al, 2007), whereas the T and Blymphocytes are involved and responsible for production of antibodies leading to enhancement of immunity (Guyton and Hall, 2006;Srikumar et al, 2007;GarlandScience, 2008;Soehnlein et al, 2008). The observed increase in the footpad thickness of the Wistar albino rats which is a measure of the DTH as a result of the challenge of the SRBC antigens could be due to some of the compounds found in the herbal extract.…”

Section: Discussionmentioning

confidence: 99%

Effect of the total crude extracts of Hibiscus sabdariffa on the immune system in the Wistar albino rats

Lubega¹

2013

Afr. J. Pharm. Pharmacol.

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Medicinal herbs are commonly used worldwide as immune boosters and immunomodulators in the management of various disease conditions. Many of these herbs commonly used have not been scientifically evaluated for their immune modulating activities. The study investigated the immunomodulatory activity of the total crude leaf extract of Hibiscus sabdariffa in Wistar albino rats. It was an experimental study that was conducted on four groups of animals each with 6 healthy adult rats. Group I was dosed each with 1mL of normal saline. Groups II, III and IV were dosed 1mL of 125, 250 and 500 mg/Kg bwt of total crude extract, daily for 14 days respectively. On the 15 th day, whole blood was collected into a clean ethlenediaminetetracetic acid (EDTA)-vacutainer. The complete blood count (CBC), immune blood cell count, hemagglutination antibody (HA) titers, neutrophil adhesion and delayed-type hypersensitivity (DTH) response were determined. All the doses caused an increase in mean red blood cell (RBC) counts as compared to control group. Similarly, the mean percentage neutrophils, monocytes, basophils and eosinophils increased with dose while the opposite was true for percentage lymphocytes. The mean HA titers for the herb were higher than control though no statistical difference (p≥0.05) was observed. Similar effects were observed with neutrophil adhesions response as that of HA titers. For DTH, the highest footpad thickness (175.2% increment) was observed at a dose of 500 mg/Kg bwt after 12 h and was statistically significant (p≤0.05) as compared to control. H. sabdariffa contain compounds with immunomodulatory activity in Wistar albino rats.

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Immunomodulatory Effect of Triphala during Experimentally Induced Noise Stress in Albino Rats

Cited by 8 publications

References 11 publications

Effect of Acorus Calamus Linn. And Its Active Principle on Noise Stress-Induced Changes on Immune System

Effect of Acorus Calamus Linn. And Its Active Principle on Noise Stress-Induced Changes on Immune System

Effect of Scoparia dulcis on noise stress induced adaptive immunity and cytokine response in immunized Wistar rats

Effect of the total crude extracts of Hibiscus sabdariffa on the immune system in the Wistar albino rats

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