Immunomodulatory and antibacterial activities of extracts from Rutaceae species

Costa, José Fernando Oliveira; Juíz, Paulo José Lima; Pedro, André São; David, Juceni P.; David, Jorge; Giulietti, Ana María; França, Flávio; Santos, Ricardo Ribeiro dos; Soares, Milena Botelho Pereira

doi:10.1590/s0102-695x2010000400007

Cited by 10 publications

(6 citation statements)

References 9 publications

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“…Brazil is home to one of the richest floras in the world, with about 10% of the world's total species (MUGGE et al, 2016). Brazilian megadiversity represents an invaluable source of new substances, derived from the secondary metabolism of plants, which may present antimicrobial (COSTA et al, 2010;SILVA et al, 2017), antioxidant (PEREIRA et al, 2016;SANTI et al, 2017) and acaricide activity (FERRAZ et al, 2017). In addition, many products marketed by the pharmaceutical industry, originate from plants, being possible to mention digoxin from Digitalis spp.…”

Section: Introductionmentioning

confidence: 99%

Biological activities and phytochemical screening of leaf extracts from Zanthoxylum caribaeum L. (Rutaceae)

et al. 2020

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The Brazilian flora is known for its vast biodiversity; however, many species have been still little studied regarding to their chemical composition and biological potential. Thus, this study aimed to determine the antimicrobial, antioxidant and acaricidal activity of the extracts of leaves of Zanthoxylum caribaeum L. In addition, phytochemical screening of these extracts was carried out to determine the main classes of secondary metabolites present in Z. caribaeum. Using the Z. caribaeum leaves, the aqueous extract and extracts were obtained in organic solvents (ethanol, methanol, hexane, acetone, dichloromethane and ethyl acetate). The antimicrobial activity of extracts was determined by broth microdilution method, and to detect antioxidant activity the method of capturing the free radical 2,2-diphenyl-1-picryl hydrazyl (DPPH) was used. The acaricidal activity of the extracts was tested on Dermanyssus gallinae (De Geer) (Acari: Dermanissidae). Ethanolic and methanolic extracts presented antimicrobial activity for most of the bacterial strains tested, as well as for yeast Candida albicans. The ethanolic extract presented high free radical sequestration potential (71.2%) and antioxidant capacity (the lowest IC50 value - 24.39 μg mL-1). The extracts obtained with methanol and acetone were the most promising. In general, phytochemical screening indicated the presence of steroids, flavanones, flavones, flavonols, saponins, tannins, triterpenoids and xanthones.

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Section: Introductionmentioning

confidence: 99%

Biological activities and phytochemical screening of leaf extracts from Zanthoxylum caribaeum L. (Rutaceae)

et al. 2020

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“…However, the potential of vascular plants as a source for a new medicine is still largely unexplored. Only a small percentage have been recorded phytochemically among the estimated about 500000 species (1) in which the medicinal aspects and antimicrobial agents of Rutaceae plants were investigated by some previous studies (2,3).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activities of ethanolic extract of four species of Rutaceae family

et al. 2020

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In this study, the antibacterial activity of ethanolic extract from the leaves of four Rutaceae species, including Acronychia pedunculata, Clausena excavata, Glycosmis pentaphylla and Luvunga scandens, were performed using the agar disk diffusion method for the first time. The ethanolic extracts from the leaves of A. pedunculata and G. pentaphylla were able to resist against all six bacterial strains with zones of inhibition for Bacillus cereus (17.3±2.1 mm, 20.8±1.0 mm) Staphylococcus aureus (8.5±0.5 mm, 17.6±0.3 mm) Escherichia coli (16.7±2.1 mm, 15.3±1.2 mm), Pseudomonas aeruginosa (11.7±0.6 mm, 14.0±1.7 mm), Salmonella enteritidis (22.3±0.6 mm, 24.6±0.5 mm) and Salmonella typhimurium (9.5±0.9 mm, 8.3±0.6 mm). On the other hand, the ethanolic extract of C. excavata leaf was resistant to B. cereus (12.3±0.6 mm), S. aureus (11.6±0.5 mm), E. coli (11.5±2.1 mm), P. aeruginosa (10.6±0.3 mm) while B. cereus (8.2±0.3 mm), S. aureus (9.3±0.6 mm), E. coli (8.5±0.5 mm) and S. typhimurium (8.3±0.6 mm) were inhibited by the ethanolic extract of L. scandens leaf. This study could provide necessary information for further application of these species in medicine.

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“…In these plant species, there is great potential for pharmacological use (Barreiro & Bolzani 2009). Studies by Costa et al, 2008;Costa et al, 2010 demonstrated that the Brazilian semiarid region has plants with immunomodulatory and antibacterial activities.…”

Section: Introductionmentioning

confidence: 99%

In silico screening of brazilian semiarid compounds to identify potential drugs with glucocorticoid receptor interaction

Filho¹,

Lima²,

Cedro³

et al. 2020

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The glucocorticoid receptor regulates the anti-inflammatory response, and prevents transcription of anti-inflammatory substances such as nuclear factor kB and lipocortin-1, IL-2, IL-6, TNF and prostaglandins. Thus, a search for new molecules with potential interaction with the glucocorticoid receptor is an interesting strategy for the treatment of inflammatory diseases. Virtual screening has proven to be a viable tool for discovering new products at lower cost and practicality. Thus, the aim of this study is to identify and evaluate brazilian semiarid compounds with anti-inflammatory potential with glucocorticoid receptor action through molecular coupling. Protein selection was performed by searching the 3D structure database, Protein Data Bank. A total of 382 semi-arid molecules available in the ZINC database of State University of Feira de Santana (UEFS) were used. Molecular docking was performed using Autodock Vina and as interaction clouds analyzed by the Discovery Studio Visualizer program. Mometasone furoate shows a binding energy of -12.7 Kcal.mol-1. A ZINC 69481862 molecule fits Lipinski and Veber rules, however, the best interaction was the ZINC 69482012 molecule, evidenced by the binding energy -11.2 Kcal.mol-1. Analyses of intermolecular interactions have shown that Van der Waals interactions and electrostatic bonds are crucial for the binding of the molecule at the receptor's active site. It is necessary to test in vitro to verify the viability and toxicity of the potential drug.

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Immunomodulatory and antibacterial activities of extracts from Rutaceae species

Cited by 10 publications

References 9 publications

Biological activities and phytochemical screening of leaf extracts from Zanthoxylum caribaeum L. (Rutaceae)

Biological activities and phytochemical screening of leaf extracts from Zanthoxylum caribaeum L. (Rutaceae)

Antibacterial activities of ethanolic extract of four species of Rutaceae family

In silico screening of brazilian semiarid compounds to identify potential drugs with glucocorticoid receptor interaction

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