Immunomodulatory agents for idiopathic pulmonary fibrosis

An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses

“…Five systematic reviews (Cochrane Database) were considered, three of which included data on breathlessness [ 167 - 169 ]. Paramothayan et al [ 170 ] reviewed 13 trials of corticosteroids for pulmonary sarcoidosis, concluding that oral steroids may be of use in some circumstances.…”

“…Paramothayan et al [ 168 ] further reviewed five trials and found limited evidence to support the use of immunosuppressive and cytotoxic therapy for this condition. Davis et al [ 167 ] reviewed three trials and found little to justify routine use of non-corticosteroid agents for idiopathic pulmonary fibrosis (IPF), and Richeldi et al [ 171 ] found no evidence for an effect of corticosteroid treatment in patients with IPF. Polosa et al [ 169 ] reviewed a single small trial of nebulised morphine in interstitial lung disease (six participants), which reported no improvement in maximal exercise performance or reduction in breathlessness during exercise.…”

An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses

“…Five systematic reviews (Cochrane Database) were considered, three of which included data on breathlessness [ 167 - 169 ]. Paramothayan et al [ 170 ] reviewed 13 trials of corticosteroids for pulmonary sarcoidosis, concluding that oral steroids may be of use in some circumstances.…”

“…Paramothayan et al [ 168 ] further reviewed five trials and found limited evidence to support the use of immunosuppressive and cytotoxic therapy for this condition. Davis et al [ 167 ] reviewed three trials and found little to justify routine use of non-corticosteroid agents for idiopathic pulmonary fibrosis (IPF), and Richeldi et al [ 171 ] found no evidence for an effect of corticosteroid treatment in patients with IPF. Polosa et al [ 169 ] reviewed a single small trial of nebulised morphine in interstitial lung disease (six participants), which reported no improvement in maximal exercise performance or reduction in breathlessness during exercise.…”

Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation

“…Steroids are widely recognized for their effectiveness in treating inflammation in various tissues, including fibroblasts ( 15 - 18 ). Glucocorticoids, a class of steroids, are known for their potent anti-fibrotic, anti-inflammatory, and immunomodulatory properties, making them a common choice for treating a wide range of acute and chronic inflammatory conditions ( 19 - 22 ). However, it’s worth noting that while corticosteroids are highly effective in managing inflammatory conditions like asthma, their efficacy is relatively lower in diseases such as chronic obstructive pulmonary disease ( 23 ).…”

NFATc3 Promotes Pulmonary Inflammation and Fibrosis by Regulating Production of CCL2 and CXCL2 in Macrophages

“…The bleomycin mouse-IPF model demonstrates that inflammation precedes fibrosis, which occurs through innate and adaptive immunity [25][26][27]. It is well established in the literature that NFAT proteins regulate both adaptive and innate immunity by fine tuning various cytokine and chemokine genes.…”

An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses

“…Five systematic reviews (Cochrane Database) were considered, three of which included data on breathlessness [ 167 - 169 ]. Paramothayan et al [ 170 ] reviewed 13 trials of corticosteroids for pulmonary sarcoidosis, concluding that oral steroids may be of use in some circumstances.…”

“…Paramothayan et al [ 168 ] further reviewed five trials and found limited evidence to support the use of immunosuppressive and cytotoxic therapy for this condition. Davis et al [ 167 ] reviewed three trials and found little to justify routine use of non-corticosteroid agents for idiopathic pulmonary fibrosis (IPF), and Richeldi et al [ 171 ] found no evidence for an effect of corticosteroid treatment in patients with IPF. Polosa et al [ 169 ] reviewed a single small trial of nebulised morphine in interstitial lung disease (six participants), which reported no improvement in maximal exercise performance or reduction in breathlessness during exercise.…”

Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation

“…Steroids are widely recognized for their effectiveness in treating inflammation in various tissues, including fibroblasts ( 15 - 18 ). Glucocorticoids, a class of steroids, are known for their potent anti-fibrotic, anti-inflammatory, and immunomodulatory properties, making them a common choice for treating a wide range of acute and chronic inflammatory conditions ( 19 - 22 ). However, it’s worth noting that while corticosteroids are highly effective in managing inflammatory conditions like asthma, their efficacy is relatively lower in diseases such as chronic obstructive pulmonary disease ( 23 ).…”

NFATc3 Promotes Pulmonary Inflammation and Fibrosis by Regulating Production of CCL2 and CXCL2 in Macrophages

“…The bleomycin mouse-IPF model demonstrates that inflammation precedes fibrosis, which occurs through innate and adaptive immunity [25][26][27]. It is well established in the literature that NFAT proteins regulate both adaptive and innate immunity by fine tuning various cytokine and chemokine genes.…”

An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses

“…Five systematic reviews (Cochrane Database) were considered, three of which included data on breathlessness [ 167 - 169 ]. Paramothayan et al [ 170 ] reviewed 13 trials of corticosteroids for pulmonary sarcoidosis, concluding that oral steroids may be of use in some circumstances.…”

“…Paramothayan et al [ 168 ] further reviewed five trials and found limited evidence to support the use of immunosuppressive and cytotoxic therapy for this condition. Davis et al [ 167 ] reviewed three trials and found little to justify routine use of non-corticosteroid agents for idiopathic pulmonary fibrosis (IPF), and Richeldi et al [ 171 ] found no evidence for an effect of corticosteroid treatment in patients with IPF. Polosa et al [ 169 ] reviewed a single small trial of nebulised morphine in interstitial lung disease (six participants), which reported no improvement in maximal exercise performance or reduction in breathlessness during exercise.…”

Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation

“…Steroids are widely recognized for their effectiveness in treating inflammation in various tissues, including fibroblasts ( 15 - 18 ). Glucocorticoids, a class of steroids, are known for their potent anti-fibrotic, anti-inflammatory, and immunomodulatory properties, making them a common choice for treating a wide range of acute and chronic inflammatory conditions ( 19 - 22 ). However, it’s worth noting that while corticosteroids are highly effective in managing inflammatory conditions like asthma, their efficacy is relatively lower in diseases such as chronic obstructive pulmonary disease ( 23 ).…”

NFATc3 Promotes Pulmonary Inflammation and Fibrosis by Regulating Production of CCL2 and CXCL2 in Macrophages

“…The bleomycin mouse-IPF model demonstrates that inflammation precedes fibrosis, which occurs through innate and adaptive immunity [25][26][27]. It is well established in the literature that NFAT proteins regulate both adaptive and innate immunity by fine tuning various cytokine and chemokine genes.…”