Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro

Curcumin Suppresses T Cell Activation by Blocking Ca2+ Mobilization and Nuclear Factor of Activated T Cells (NFAT) Activation

“…Curcumin has been shown to inhibit NF-B activity in various cell types including T cells and, therefore, inhibition of NF-B has been suggested to be the main mechanism of curcumin-mediated suppression of cytokine expression (31). Because NFAT is a key regulator of T cell function and has been shown to be essential for activating most T cell cytokine genes (32,33), we examined the effect of curcumin on NFAT activity.…”

Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells

“…We used 1 µM resveratrol since a similar resveratrol concentration is reached in the plasma of rats after oral administration of red wine [38]. The 50 µM concentration was not cytotoxic in a neuroblastoma cell line [39] and almost completely inhibited lymphocyte cell proliferation [40].…”

Curcumin induces apoptosis through the mitochondria-mediated apoptotic pathway in HT-29 cells

“…Curcumin has been used for a long time as a naturally occurring medicine in treatment of many diseases . Several studies have shown that curcumin possesses anti-proliferative and anti-carcinogenic properties in a wide variety of cell lines and animals (Gao et al, 2004;Aggarwal et al, 2006). Curcumin is described to efficiently induce apoptosis in various cell lines, including NIH 3T3, HL-60, K562, H520, and HeLa (Bhaumik et al, 2000;Sen et al, 2005).…”