Immunological responses of patients with psoriasis and the effect of treatment with methotrexate

Levantine, Ashley; Brostoff, Jonathan

doi:10.1111/j.1365-2133.1975.tb05116.x

Cited by 34 publications

(6 citation statements)

References 9 publications

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“…Sensitization to DNCB was found to occur less frequently in patients with psoriasis as compared to non-psoriatics (Epstein & Maibach, 1965). Also, a lowered mitogenic response to PHA, Con A and PWM was observed (Levantine & Brostoff, 1976;Guilhou et al, 1975). recently noted decreased numbers of T cells in the peripheral blood of psoriatic patients as evaluated by Erosettes.…”

Section: Discussionmentioning

confidence: 98%

Lymphocyte activation by streptococcal antigens in psoriasis

Gross¹,

Packhäuser²,

Hahn³

et al. 1977

Br J Dermatol

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Cell-mediated immune responses in 28 hospitalized patients with psoriasis and in 36 healthy controls were studied using the two-step leukocyte migration agarose test. Specific cell-mediated immunity to A-streptococcal cell wall and cell membrane antigens occurred significantly more often in patients with psoriasis than in the control group. A statistically significant correlation between psoriasis-associated antigens of the HLA-B locus and cellular immune reactivity to A-streptococcal antigens or clinical course was not found. When patients with guttate psoriasis were compared separately with the control group, leukocyte migration inhibition induced by cell-free supernatants of A-streptococcal antigen-exposed mononuclear cell cultures was found to be more frequent than in other forms of psoriasis.

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Section: Discussionmentioning

confidence: 98%

Lymphocyte activation by streptococcal antigens in psoriasis

Gross¹,

Packhäuser²,

Hahn³

et al. 1977

Br J Dermatol

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“…These anomalies may be explained by a shift toward T suppressor cells of the T helper/T suppres sor cell ratio in the peripheral blood in psoriasis as reported 115]. There are, however, also reports suggesting a normal lymphocyte proliferation in patients with psoriasis [16][17][18]. Moreover, it has recently been found that soluble intcrlcukin-2 receptors, indicating lymphocyte activation, are elevated in psoriatic serum even after clinical remission 119-21 ].…”

Section: Discussionmentioning

confidence: 96%

Chloroquine Stimulates the Mitogen-Driven Lymphocyte Proliferation in Patients with Psoriasis

Schopf

Ockenfels²,

Schultewolter³

et al. 1993

Dermatology

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Chloroquine is known to exacerbate psoriasis. Since immunological stimuli are considered to be important for the pathogenesis of psoriasis, we compared the effects of chloroquine on cell-mediated immunity in 15 healthy control individuals and 15 patients with psoriasis. We employed the spontaneous and phytohemagglutin (PHA)-induced uptake of ³H-thymidine to measure lymphocyte proliferation. Chloroquine was added to the cultures at concentrations ranging from 0.022 to 220 μM. We found that both spontaneous and PHA-driven lymphocyte proliferations were significantly lower in patients with psoriasis (p < 0.002). The spontaneous blastogenesis in both controls and patients remained stable under chloroquine. In PHA-driven cultures in controls, 0.022––2.2 μM chloroquine had no effect, higher concentrations of the drug suppressed proliferation. In patients, 22 μM chloroquine surmounted the suppression of the PHA-induced proliferative response found in controls; moreover, 2.2––0.022 μM chloroquine increased lymphocyte proliferation by > 300% (p < 0.002). Our data indicate that in psoriasis the lower lymphocyte transformation is abnormally stimulated by the addition of pharmacological doses of chloroquine.

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“…A definite decrease in the E-rosette-forming lymphocytes has been reported by several investigators (Clot et al, 1975(Clot et al, , 1978Cormane, Hunyadi & Hamerlinck, 1977;Ghnski et al, 1978). Normal levels of E-rosette-forming cells have also been claimed (Levantine & Brostoff, 1975;Heid et al, 1976;Lischka, t976). The lymphocyte response to phytohaemagglutinin (PHA) in psoriatics has been reported to be normal (Hopsu-Havu & Helander, 1975;Clot et al, 1978) but that to concanavalin A (Con A) abnormally low (Clot et al, 1978).…”

mentioning

confidence: 88%

Effect of 8-methoxypsoralen plus UVA (PUVA) on lymphocyte transformation and T cells in psoriatic patients

1979

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The peripheral blood lympochytes of the psoriatic patients studied initially showed a normal response to phytohaemagglutinin (PHA) and to purified protein derivative of tuberculin (PPD) in a microculture using whole blood, but a lower than normal response to a high concentration of concanavalin A (Con A). The initial level of E-rosette-forming T cells in psoriatic patients (51 3%) was significantly lower than that in healthy controls (66 7/,,).A single exposure to 8-methoxypsoralen (8-MOP) and UVA light (PUVA) did not suppress the lymphocyte responses to PHA, Con A or PPD, rather the responses showed a tendency to be slightly increased. Sitnilarly, no changes in the mitogen responses of peripheral blood lymphocytes were recorded during or after 12 weeks PUVA therapy for psoriasis. The lymphocytes still showed a weaker than normal response to a high concentration of Con A. However, the percentage of E-rosette-forming T cells in the peripheral blood increased from 51*3% to 62-8% after 12 weeks PUVA therapy.The low initial level of E-rosette-forming T cells was found to correlate more closely with the activity than with the extent of the disease. The increase found in the E-rosette-forming cells during PUVA therapy did not correlate with the improvement of the psoriatic lesions. The low response of peripheral blood lymphocytes of psoriatic patients to a high concentration of Con A correlated with the age of the patients but not with the activity or extent of the disease.

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Immunological responses of patients with psoriasis and the effect of treatment with methotrexate

Cited by 34 publications

References 9 publications

Lymphocyte activation by streptococcal antigens in psoriasis

Lymphocyte activation by streptococcal antigens in psoriasis

Chloroquine Stimulates the Mitogen-Driven Lymphocyte Proliferation in Patients with Psoriasis

Effect of 8-methoxypsoralen plus UVA (PUVA) on lymphocyte transformation and T cells in psoriatic patients

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