Immunologic response to administration of standardized dog allergen extract at differing doses

Lent, Anne M.; Harbeck, Ronald J.; Strand, Matthew; Sills, Michael; K, Schmidt; Efaw, Benjamin; Lebo, Terri; Nelson, Harold S.

doi:10.1016/j.jaci.2006.07.055

Cited by 58 publications

(57 citation statements)

References 24 publications

(31 reference statements)

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“…Meanwhile, changes in specific IgE, which initially increases in the up-dosing phase and then decreases to basal levels a few months later [30], is not as consistent as other immunological markers, such as the IgG4 level [19]. After 1 year of treatment, we, together with others [19, 31, 32], have not recorded a significant change in levels of specific IgE in either cluster or conventional schedules.…”

Section: Discussionmentioning

confidence: 74%

Comparative Study of Cluster and Conventional Immunotherapy Schedules with <i>Dermatophagoides pteronyssinus</i> in the Treatment of Persistent Allergic Rhinitis

Zhang

Han

Wang

et al. 2008

Int Arch Allergy Immunol

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Background and Objectives: Allergy to house dust mite is one of the most common causes of allergic rhinitis (AR) in China. We sought to compare the efficacy and safety of a 6-week cluster schedule of specific immunotherapy with that of a 14-week conventional schedule for the treatment of subjects with persistent AR. Methods: The trial was a prospective and randomized study involving 96 patients with persistent AR, aged 14–60 years, who were allergic to Dermatophagoides pteronyssinus. While 48 patients were randomly assigned to the cluster schedule reaching the maintenance dose within 6 weeks, the other 48 were randomly assigned to the conventional schedule reaching the maintenance dose within 14 weeks. Eighty-nine patients completed a 1-year treatment course. While kinetic changes in clinical efficacy and adverse reactions were observed during the treatment, quality of life, cutaneous reactivity and serum-specific immunoglobulin E to Dermatophagoides pteronyssinus were measured before and after treatment. Results: The cluster schedule reduced the time to reach the maintenance dose by 57% and caused mild systemic adverse reactions after 1.0% of injections (6.7% of patients), with no differences in comparison with the conventional schedule. Cluster specific immunotherapy led to decreases in clinical symptoms and earlier use of medication than did the conventional schedule. Similar improvements in quality of life and reduced cutaneous reactivity without significant changes in specific immunoglobulin E were observed in both groups after 1 year. Conclusions: The cluster schedule is a safe alternative to the conventional schedule with the advantage of achieving clinical effectiveness sooner.

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Section: Discussionmentioning

confidence: 74%

Comparative Study of Cluster and Conventional Immunotherapy Schedules with <i>Dermatophagoides pteronyssinus</i> in the Treatment of Persistent Allergic Rhinitis

Zhang

Han

Wang

et al. 2008

Int Arch Allergy Immunol

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“…Such early impact on cutaneous responses (SDSPT) is also found from cluster immunotherapy treatments with HDM allergens, as well as with other inhalants. 36,37,38,39,40 For practical reasons we did not measure the delayed cutaneous responses although other reports have considered that it could be evidence for symptoms improvement. 22,41 We did measure the papule size at the site of the ID injection (papule read at 15 min) the day of the fi rst and last injection, fi nding a non-signifi cant diminution.…”

Section: Discussionmentioning

confidence: 99%

Intradermal immunotherapy with low-dose house dust mite allergens in patients with allergic rhinitis: A proof-of-concept study

Vieira-Hernández¹,

Capriles‐Hulett²,

Sánchez‐Borges³

et al. 2018

RAM

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Antecedentes: La inmunoterapia subcutánea acuosa a altas dosis es una ruta validada y efectiva de administración de alérgenos para el ácaro del polvo doméstico y alergias al polen.Objetivos: Estudio de definición conceptual empleando inmunoterapia intradérmica (ITID) con alérgenos de ácaros (Dermatophagoides pteronyssinus/Dermatophagoides farinae [Dp/Df] y Blomia tropicalis [Bt]) a bajas dosis; se llevó a cabo en niños con rinitis alérgica sintomáticos a la exposición de polvo de casa. Métodos: A ocho pacientes sin uso previo de inmunoterapia, con pruebas de punción cutánea positivas e IgE sérica específica a una mezcla de Dp/Df y Bt, se les administraron por tres meses 0.05 mL de ITID semanalmente, provenientes de una preparación fenolizada albúmino-salina y contentiva de bajas dosis de ácaros (8.3 AU= 5 ng de Dp/Df y 2.5 DBU de Bt). Los síntomas nasales (Total Nasal Symptom Score) y los faciales (Escala Análoga Visual) fueron registrados dos semanas antes del tratamiento y en el transcurso una vez a la semana. Al comienzo y al final se realizaron pruebas cutáneas diluidas y seriadas (1/100-1/1.000.000) y determinaciones de IgG4 en el suero para los alérgenos. Resultados: Los valores de las escalas sugirieron mejoría clínica. Existió disminución significativa de los diámetros de las pápulas de las pruebas diluidas y seriadas, así como aumento de los valores de la IgG4 sérica al final del tratamiento. La ITID fue bien tolerada.Conclusión: Si estudios ulteriores confirman los presentes hallazgos, se podría promover una mayor utilización de la inmunoterapia alérgeno-específica.

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“…[74][75][76][77][78][79][80][81] Immunotherapy is effective for the treatment of allergic rhinitis 77 (including ocular symptoms 82 ), allergic asthma, 74,79,81,83,84 and stinging insect hypersensitivity 78,85 and is effective in both adults and children. [86][87][88][89][90][91][92] Its efficacy is confirmed for the treatment of inhalant allergy caused by pollens, 93-101 fungi, 102-107 animal allergens, 18,21,22,47,[108][109][110][111] dust mites, 17,83,84,[112][113][114][115][116][117][118][119][120] and cockroaches. 121 There have been no controlled trials of fire ant whole-body extract, but it does appear to be effective in uncontrolled trials.…”

Section: Efficacy Of Immunotherapymentioning

confidence: 99%

“…Effective subcutaneous allergen immunotherapy appears to correlate with administration of an optimal maintenance dose in the range of 5 to 20 mg of major allergen for inhalant allergens. [17][18][19][20][21][22] It should be differentiated from unproved methods, such as neutralization-provocation therapy 23 and low-dose subcutaneous regimens based on the Rinkel technique, 24,25 which have been found to be ineffective in double-blind, placebo-controlled trials. The selection of allergens for immunotherapy is based on clinical history, the presence of specific IgE antibodies, and allergen exposure.…”

Section: Introductionmentioning

confidence: 99%

Allergen immunotherapy: A practice parameter third update

Cox

Nelson

Lockey

et al. 2011

Journal of Allergy and Clinical Immunology

1,005

1,054

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Immunologic response to administration of standardized dog allergen extract at differing doses

Cited by 58 publications

References 24 publications

Comparative Study of Cluster and Conventional Immunotherapy Schedules with <i>Dermatophagoides pteronyssinus</i> in the Treatment of Persistent Allergic Rhinitis

Comparative Study of Cluster and Conventional Immunotherapy Schedules with <i>Dermatophagoides pteronyssinus</i> in the Treatment of Persistent Allergic Rhinitis

Intradermal immunotherapy with low-dose house dust mite allergens in patients with allergic rhinitis: A proof-of-concept study

Allergen immunotherapy: A practice parameter third update

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