Immunologic Reactions in Psoriasis

Treatment of Psoriasis with Topical Agents

“…The main objective of cytotoxic drugs developed in the 20th century, such as methotrexate, was to reduce keratinocyte proliferation. However, immunological studies on psoriatic patients identified changes in humoral immune response as part of the overall problem but not the cause [16,17]. The efficacy of cytotoxic drugs in the late 1960s paved the road for ideas about the role of the immune system in psoriasis [18,19].…”

Psoriasis as a Chess Board — An Update of Psoriasis Pathophysiology

“…The main objective of cytotoxic drugs developed in the 20 th century, such as methotrexate, was to reduce keratinocyte proliferation. Immunological studies on psoriatic patients identified changes in humoral immune reactions as part of the overall problem but not the cause [8,9]. Efficacy of the cytotoxic drugs in the late 1960s paved the road for ideas about the role of the immune system in psoriasis [10,11].…”

Targeting IL-23: Insights into the pathogenesis and the treatment of psoriasis

“…Immunological studies on psoriatic patients indentified changes in humoral immune reactions as part of the overall problem but not the cause. [67] Eventually, other studies identified that the action of cytotoxic drugs extended to the immune system of patients with psoriasis. [89] However, the dominant thought was that psoriasis was a disease of faulty epidermopoiesis due to impaired autocontrol mechanisms.…”