Immunohistologic patterns of congenital nevocellular nevi

Nickoloff, B. J.

doi:10.1001/archderm.122.11.1263

Cited by 12 publications

(7 citation statements)

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“…The histologic appearance of the findings from the repeated biopsies revealed no noteworthy change compared with the ap- pearance of the original biopsy findings. 26 This suggests that major events in the evolution of CMN do not occur in the first and second decades of life but does not exclude the possibility that those events may occur later in life.…”

Section: Commentmentioning

confidence: 97%

“…25 But because most of the study participants were in the first decade of life and included only 2 individuals older than 20 years, these findings do not necessarily preclude the possibility that major histologic changes in CMN may become apparent after the first decade of life. In the study by Nickoloff et al, 26 biopsy samples of 10 small CMN from individuals younger than 1 year were obtained and compared with findings from repeated biopsies obtained after a mean follow-up period of 10.25 years. The histologic appearance of the findings from the repeated biopsies revealed no noteworthy change compared with the ap- pearance of the original biopsy findings.…”

Section: Commentmentioning

confidence: 99%

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Age- and Site-Specific Variation in the Dermoscopic Patterns of Congenital Melanocytic Nevi

Changchien¹,

Dusza²,

Agero³

et al. 2007

Arch Dermatol

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Section: Commentmentioning

confidence: 97%

Section: Commentmentioning

confidence: 99%

Age- and Site-Specific Variation in the Dermoscopic Patterns of Congenital Melanocytic Nevi

Changchien¹,

Dusza²,

Agero³

et al. 2007

Arch Dermatol

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“…Other groups confirmed that acquired nevi often exhibit ''congenital'' histologic features, [16][17][18][19] and congenital nevi may present with predominantly junctional histologic changes (Table 1). [18][19][20][21][22][23][24][25] As apparent from Table 1, the original criteria by Mark et al 12 were subject to modifications by subsequent authors. An important example of these modifications is represented by the controversy as to whether the presence of nevus cells inside or only around adnexal epithelia is a characteristic feature of congenital nevi.…”

Section: Congenital Nevimentioning

confidence: 99%

Nevogenesis-New Thoughts Regarding a Classical Problem

Krengel¹

2005

The American Journal of Dermatopathology

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The development of melanocytic nevi is a multifactorial and heterogeneous biologic process that involves prenatal and postnatal steps. As a consequence, there are two main perspectives to nevi: that of a hamartoma and that of a benign tumor. In this review, dermatopathological studies on congenital and acquired nevi, including studies on age-related and location-dependent changes, are analyzed. These studies have lead to different hypothetical concepts on the evolution of individual lesions. In the light of findings from experimental embryology and stem cell biology, we discuss the histogenesis of nevi with special reference to the temporospatial sequence of melanocyte-basement membrane interactions and hair follicle genesis. Regarding the mechanisms of postnatal nevus development, epidemiological studies demonstrate the importance of constitutional and environmental influences, especially ultraviolet light. Possible molecular pathways of solar nevogenesis involve ultraviolet-induced alterations of the cellular microenvironment (eg, changes in the expression of cytokines and melanocyte adhesion molecules). Recent results and future directions of clinical and experimental research are presented.

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“…Re-pigmentation first appeared 2 months after curettage, with a mean of 3 months. Patients [15,21,22]. Others noticed the importance of nevus size in determining the extent of dermal involvement already in the early postnatal period [1,8,24].…”

Section: Resultsmentioning

confidence: 99%

Results of early curettage of giant congenital melanocytic nevi; a report of eight cases and review of the literature

2007

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The aim of this study was to investigate the longterm cosmetic and oncologic results following early curettage of giant congenital melanocytic nevi (GCMN). Neonates with GCMN treated with curettage within 4 weeks of age and with a minimum follow-up of 2 years were evaluated at the outpatient department. Scar formation was evaluated by means of the patient and observer scar assessment scale (POSAS). Biopsy specimens were analysed. In 9 years, eight neonates were treated. The mean follow-up period was 5.6 years. Six (75%) patients developed re-pigmentation of the curetted skin, hypertrichosis returned in five cases. One patient developed hypertrophic scars, all others formed good scars. None of the patients developed a melanoma. Biopsy specimens showed nevus cells in the skin after curettage. In 50% of the patients curettage is followed by severe re-pigmentation. Since this treatment does not remove all nevus cells, long-term followup is essential to detect malignant transformation.

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Immunohistologic patterns of congenital nevocellular nevi

Cited by 12 publications

References 0 publications

Age- and Site-Specific Variation in the Dermoscopic Patterns of Congenital Melanocytic Nevi

Age- and Site-Specific Variation in the Dermoscopic Patterns of Congenital Melanocytic Nevi

Nevogenesis-New Thoughts Regarding a Classical Problem

Results of early curettage of giant congenital melanocytic nevi; a report of eight cases and review of the literature

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