Immunohistochemical study of osteopontin and l-selectin in a rat endometriosis model and in human endometriosis

Smooth muscle metaplasia and innervation in interstitium of endometriotic lesions related to pain

“…With regards to other cytokines, we demonstrated the up-regulation of TGF-b1, monocyte chemoattractant protein-1, and OPN in our gene expression analysis with oligonucleotide microarrays in human endometriosis (15) and in a rat endometriosis model (16). Furthermore, we immunohistochemically demonstrated up-regulation of OPN in an endometriotic lesion (37). Therefore, we believe that such cytokine inhibitors might also be effective in endometriotic remodeling and result in the relief of endometriotic pain.…”

Expression and localisation of osteopontin and prominin-1 (CD133) in patients with endometriosis

“…However, endometriosis has been found to be associated with changes in the expression of several genes, including cytokines (19), such as the multifunctional cytokine OPN, which has been intensively investigated in endometriosis (7,8,10,20). …”

“…However, various studies on the endometrial expression of OPN in patients with endometriosis have provided controversial results. A previous study demonstrated that the OPN protein is densely expressed in eutopic normal endometrium, as well as in epithelial cells of endometriotic cysts (7). Moreover, OPN mRNA expression, as well as its plasma levels, have been shown to be higher in patients with endometriosis compared to normal subjects (8).…”

Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis

“…The uterus, abdominal wall, and liver were excised and weighed. In the remaining six rats, one horn of the uterus was cut (5 by 5 mm 2 , 2 sections) and autotransplanted to the peritoneum to induce endometriosis as previously described (15,16). Two and 4 weeks later, three rats from each group were killed.…”