Immunohistochemical Study of Bone Sialoprotein and Osteopontin in Healthy and Diseased Root Surfaces

Abstract

The absence of bone sialoprotein and osteopontin staining along exposed cementum surfaces may be due to structural and compositional changes in matrix components associated with periodontal disease. This may influence the ability for regeneration and new connective tissue attachment onto previously diseased root surfaces.

Extracellular matrix expression and periodontal wound‐healing dynamics following guided tissue regeneration therapy in canine furcation defects

“…They inhibited or delayed the formation of collagens as well as the expression of BSP and OPN along the root surfaces, which seem to be crucial for new cementum formation. This confirms recently published immunohistochemical findings (Lao et al 2006), which also showed absence of BSP and OPN staining along pathologically exposed human cementum surfaces.…”

Extracellular matrix expression and periodontal wound‐healing dynamics following guided tissue regeneration therapy in canine furcation defects

“…They inhibited or delayed the formation of collagens as well as the expression of BSP and OPN along the root surfaces, which seem to be crucial for new cementum formation. This confirms recently published immunohistochemical findings (Lao et al 2006), which also showed absence of BSP and OPN staining along pathologically exposed human cementum surfaces.…”

Immunohistochemical Evaluation of Periodontal Regeneration Using a Porous Collagen Scaffold

“…Loss of BSP caused progressive disorientation of the PDL due to structural defects in the cementum-PDL interface, highlighting the significance of BSP for periodontal function [28]. Furthermore, an immunohistochemical study with healthy and periodontitis-affected human teeth has shown that BSP could not be detected on exposed cementum (absence of overlying PDL) of periodontally compromised teeth [53]. The authors concluded that the lack of BSP may influence the ability for regeneration and new connective tissue attachment onto previously diseased root surfaces [53].…”

Bone biology‐related gingival transcriptome in ageing and periodontitis in non‐human primates

“…, Lao et al. ) indicating multiple functions. OPN is produced by T cells, macrophages, osteoclasts and osteoblasts, binds to mineral and signals through several integrin receptors which includes α v β 3 and CD44.…”

“…The up-regulated genes were those promoting osteoclast differentiation and activity which include SPP1, SMEK3P, MMP8, TLR4, TFEC and BMP3 expression. SPP1 encodes for Osteopontin (OPN) which is major component of mineralized matrix and is expressed by a variety of cells in soft and hard tissues (Sodek et al 2000, Lao et al 2006) indicating multiple functions. OPN is produced by T cells, macrophages, osteoclasts and osteoblasts, binds to mineral and signals through several integrin receptors which includes avb3 and CD44.…”

Extracellular matrix expression and periodontal wound‐healing dynamics following guided tissue regeneration therapy in canine furcation defects

“…They inhibited or delayed the formation of collagens as well as the expression of BSP and OPN along the root surfaces, which seem to be crucial for new cementum formation. This confirms recently published immunohistochemical findings (Lao et al 2006), which also showed absence of BSP and OPN staining along pathologically exposed human cementum surfaces.…”

Immunohistochemical Evaluation of Periodontal Regeneration Using a Porous Collagen Scaffold

“…Loss of BSP caused progressive disorientation of the PDL due to structural defects in the cementum-PDL interface, highlighting the significance of BSP for periodontal function [28]. Furthermore, an immunohistochemical study with healthy and periodontitis-affected human teeth has shown that BSP could not be detected on exposed cementum (absence of overlying PDL) of periodontally compromised teeth [53]. The authors concluded that the lack of BSP may influence the ability for regeneration and new connective tissue attachment onto previously diseased root surfaces [53].…”

Bone biology‐related gingival transcriptome in ageing and periodontitis in non‐human primates

“…, Lao et al. ) indicating multiple functions. OPN is produced by T cells, macrophages, osteoclasts and osteoblasts, binds to mineral and signals through several integrin receptors which includes α v β 3 and CD44.…”

“…The up-regulated genes were those promoting osteoclast differentiation and activity which include SPP1, SMEK3P, MMP8, TLR4, TFEC and BMP3 expression. SPP1 encodes for Osteopontin (OPN) which is major component of mineralized matrix and is expressed by a variety of cells in soft and hard tissues (Sodek et al 2000, Lao et al 2006) indicating multiple functions. OPN is produced by T cells, macrophages, osteoclasts and osteoblasts, binds to mineral and signals through several integrin receptors which includes avb3 and CD44.…”

Extracellular matrix expression and periodontal wound‐healing dynamics following guided tissue regeneration therapy in canine furcation defects

“…They inhibited or delayed the formation of collagens as well as the expression of BSP and OPN along the root surfaces, which seem to be crucial for new cementum formation. This confirms recently published immunohistochemical findings (Lao et al 2006), which also showed absence of BSP and OPN staining along pathologically exposed human cementum surfaces.…”

Immunohistochemical Evaluation of Periodontal Regeneration Using a Porous Collagen Scaffold

“…Loss of BSP caused progressive disorientation of the PDL due to structural defects in the cementum-PDL interface, highlighting the significance of BSP for periodontal function [28]. Furthermore, an immunohistochemical study with healthy and periodontitis-affected human teeth has shown that BSP could not be detected on exposed cementum (absence of overlying PDL) of periodontally compromised teeth [53]. The authors concluded that the lack of BSP may influence the ability for regeneration and new connective tissue attachment onto previously diseased root surfaces [53].…”

Bone biology‐related gingival transcriptome in ageing and periodontitis in non‐human primates

“…, Lao et al. ) indicating multiple functions. OPN is produced by T cells, macrophages, osteoclasts and osteoblasts, binds to mineral and signals through several integrin receptors which includes α v β 3 and CD44.…”

“…The up-regulated genes were those promoting osteoclast differentiation and activity which include SPP1, SMEK3P, MMP8, TLR4, TFEC and BMP3 expression. SPP1 encodes for Osteopontin (OPN) which is major component of mineralized matrix and is expressed by a variety of cells in soft and hard tissues (Sodek et al 2000, Lao et al 2006) indicating multiple functions. OPN is produced by T cells, macrophages, osteoclasts and osteoblasts, binds to mineral and signals through several integrin receptors which includes avb3 and CD44.…”