Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland

Abdel-Hamid, Ehab S.; ElShafei, Marwa Mokbel

doi:10.1186/1746-1596-4-14

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…Regarding the papillary cystadenoma lymphomatosum, the bcl-2 was previously detected in 55.6% of cases, while the normal parotid gland tissues were found negative for Bcl-2 32. Abd-Elhamid and Elshafei (33) found that 90% of papillary cystadenoma lymphomatosum showed positive expression of bcl-2. They suggested a protective role of tumor cells from apoptosis to maintain the survival of cells, but not increase their malignant potentiality.…”

Section: Discussionmentioning

confidence: 99%

The differences between benign mixed tumor and papillary cystadenoma lymphomatosum in proliferative, apoptotic, and antiapoptotic activity

Khaleel¹

2019

ATMPH

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The majority of salivary glands tumors are benign mixed tumors. The present study was aimed to evaluate the differences between benign mixed salivary glands tumor and papillary cystadenoma lymphomatous regarding the tumor cell proliferation rate, apoptotic and antiapoptotic activity. The study was performed on archived paraffinembedded salivary glands tissue of 23 benign mixed tumors and five cystadenoma lymphomatosis. Sections were stained with hematoxylin and eosin and cases with the definite diagnosis were selected for immunohistochemistry. The immunoreactivity was assessed in areas of highest positivity regarding Ki-67, P53, and bcl-2. Our results refer that benign mixed tumor and papillary cystadenoma lymphomatous showed negative immune expression for Ki-67. The P53 immune staining in benign mixed tumor appeared negative, while the papillary cystadenoma lymphomatous appeared with mild positive staining. Bcl-2 immune expression in the benign mixed tumor was moderate positive while the papillary cystadenoma lymphomatous was mild positive. We conclude that the benign mixed tumors showed significantly more Ki-67 and bcl-2 immune labeling indexes than papillary cystadenoma lymphomatous, but the P53 immune expression was less (p<0.05). This indicates that the P53 expression was not observed to be correlated with the Ki-67 or bcl-2 overexpression.

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Section: Discussionmentioning

confidence: 99%

The differences between benign mixed tumor and papillary cystadenoma lymphomatosum in proliferative, apoptotic, and antiapoptotic activity

Khaleel¹

2019

ATMPH

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“…Regarding papillary cystadenoma lymphomatosum, the bcl-2 was previously detected in 55.6% of cases while normal parotid gland tissues were found negative for bcl-2 32 . Furthermore, [33] found that 90% of papillary cystadenoma lymphomatosum showed positive expression of bcl-2. They suggested a protective role of tumor cells from apoptosis to maintain survival of cells, but not increase their malignant potentiality.…”

Section: Discussionmentioning

confidence: 99%

The Differences between Benign Mixed Tumor and Papillary Cystadenoma Lymphomatosum in Proliferative, Apoptotic and Antiapoptotic Activities

Khaleel¹

2020

ATMPH

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Background:The majority of salivary glands tumors are benign mixed tumors. The present study was aimed to evaluate the differences between benign mixed salivary glands tumor and papillary cystadenoma lymphomatosum regarding the tumor cell proliferation rate, apoptotic and antiapoptotic activities. Methods: The study was performed on archived paraffin-embedded salivary glands tissue of 23 benign mixed tumor and five cystadenoma lymphomatosum. Sections were stained with hematoxylin and eosin and cases with definite diagnosis were selected for immunohistochemistry. The immunoreactivity was assessed in areas of highest positivity regarding Ki-67, P53 and bcl-2. Results: Benign mixed tumor and papillary cystadenoma lymphomatosum showed negative immune expression for Ki-67. The P53 immune staining in benign mixed tumor appeared negative while the papillary cystadenoma lymphomatosum appeared with a mild positive staining. The bcl-2 immune expression in benign mixed tumor was moderately positive while the papillary cystadenoma lymphomatosum was mildly positive. Conclusion:The benign mixed tumors showed significantly more Ki-67 and bcl-2 immune labeling indexes than papillary cystadenoma lymphomatosum, but the P53 immune expression was less (P<0.05). This indicated that the P53 expression was not correlated with the Ki-67 or bcl-2 over expression.

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“…The inhibition of cell cycle progression by p53 is mediated by multiple mechanisms, including the upregulation of p21, which inhibits the cyclin-dependent kinase (CDK) family of kinases, and transcriptional regulation of Gadd45 and 14-3-3σ. p53 maintains genomic stability and is involved in DNA repair, apoptosis, and cellular senescence [ 100 ]. The inactivation of p53 tumor suppressor genes occurs frequently during tumorigenesis.…”

Section: The Role Of P16 and P53 In Warthin’s Tumormentioning

confidence: 99%

Pathogenesis of Warthin’s Tumor: Neoplastic or Non-Neoplastic?

Aoki,

Tanaka

2024

Cancers

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Warthin’s tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland, mostly in the parotid gland. The epithelial cells constituting a tumor are characterized by the presence of mitochondria that undergo structural and functional changes, resulting in the development of oncocytes. In addition to containing epithelial cells, Warthin’s tumors contain abundant lymphocytes with lymph follicles (germinal centers) that are surrounded by epithelial cells. The pathogenesis of Warthin’s tumor is not fully understood, and several hypotheses have been proposed. The risk factors for the development of Warthin’s tumor, which predominantly occurs in males, include aging, smoking, and radiation exposure. Recently, it has been reported that chronic inflammation and aging cells promote the growth of Warthin’s tumor. Several reports regarding the origin of the tumor have suggested that (1) Warthin’s tumor is an IgG4-related disease, (2) epithelial cells that compose Warthin’s tumor accumulate mitochondria, and (3) Warthin’s tumor is a metaplastic lesion in the lymph nodes. It is possible that the pathogenesis of Warthin’s tumor includes mitochondrial metabolic abnormalities, accumulation of aged cells, chronic inflammation, and senescence-associated secretory phenotype (SASP). In this short review, we propose that DNA damage, metabolic dysfunction of mitochondria, senescent cells, SASP, human papillomavirus, and IgG4 may be involved in the development of Warthin’s tumor.

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Immunohistochemical localization of mdm-2, p27Kip1 and bcl-2 in Warthin's tumor of the parotid gland

Cited by 7 publications

References 24 publications

The differences between benign mixed tumor and papillary cystadenoma lymphomatosum in proliferative, apoptotic, and antiapoptotic activity

The differences between benign mixed tumor and papillary cystadenoma lymphomatosum in proliferative, apoptotic, and antiapoptotic activity

The Differences between Benign Mixed Tumor and Papillary Cystadenoma Lymphomatosum in Proliferative, Apoptotic and Antiapoptotic Activities

Pathogenesis of Warthin’s Tumor: Neoplastic or Non-Neoplastic?

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