Immunohistochemical localization of DARPP-32 in the brain and spinal cord of anuran amphibians and its relation with the catecholaminergic system

López, Jesús M.; Morona, Ruth; González, Agustı́n

doi:10.1016/j.jchemneu.2010.09.004

Cited by 14 publications

(12 citation statements)

References 69 publications

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“…Codistribution/Colocalization of DARPP-32 and TH Although confocal microscopy was not used in the present study, the double immunolabeling experiments showed close relationships between DARPP-32 and catecholaminergic neuronal structures in lungfishes, as in tetrapods [Ouimet et al, 1984[Ouimet et al, , 1992Schnabel et al, 1997;Durstewitz et al, 1998;Reiner et al, 1998;Absil et al, 2001;Smeets et al, 2001Smeets et al, , 2003López et al, 2010]. Also, in zebrafish, DARPP-32 cells are distributed in areas receiving dopaminergic innervation, although in this case they are primarily restricted to the cerebellum and cerebellum-like circuits [Robra and Thirumalai, 2016].…”

Section: Rhombencephalon and Upper Spinal Cordmentioning

confidence: 65%

“…References: teleost: Robra and Thirumalai [2016]; lungfishes: González and Northcutt [2009]; present results; amphibians: López et al [2010]; O'Connell et al [2010]; reptiles: Smeets et al [2001Smeets et al [ , 2003; Moreno et al [2010]; birds: Schnabel et al [1997]; Durstewitz et al [1998]; Reiner et al [1998]; Absil et al [2001]; Roberts et al [2002]; Bálint et al [2004]; Reiner et al [2004]; Metzger et al [2006]; Bálint and Csillag [2007]; Csillag et al [2008]; mammals: Ouimet et al [1984Ouimet et al [ , 1992; Ouimet and Greengard [1990]; Gustafson and Greengard [1990]; Anderson and Reiner [1991]; Perez and Lewis [1992]; Barbas et al [1993]; Greengard et al [1998]; Wang et al [2004]; Ishikawa et al [2007]; Glausier et al [2010]; Buesa et al [2016]. …”

Section: Spinal Cordmentioning

confidence: 67%

“…The presence of DARPP-32-ir cells in the habenula is a feature shared by all species of sarcopterygian vertebrates studied [Ouimet et al, 1984[Ouimet et al, , 1992Perez and Lewis, 1992;Schnabel et al, 1997;Durstewitz et al, 1998;Absil et al, 2001;Smeets et al, 2001Smeets et al, , 2003Roberts et al, 2002;López et al, 2010;O'Connell et al, 2010;present results], whereas they are absent in zebrafish [Robra and Thirumalai, 2016]. In lungfishes and birds, these immunoreactive cells are located in the lateral habenular region [Absil et al, 2001;present results], whereas in amphibians, reptiles, and mammals these cells are confined in the medial habenular subdivision [Ouimet et al, 1984[Ouimet et al, , 1992Perez and Lewis, 1992;Smeets et al, 2001Smeets et al, , 2003.…”

Section: Diencephalonmentioning

confidence: 80%

“…Likewise, DARPP-32-ir cells occupy deep layers of the optic tectum of zebrafish and the anuran amphibians studied, also receiving a strong catecholaminergic innervation Smeets, 1991, 1994;González et al, 1993;Sánchez-Camacho et al, 2002;López et al, 2010;O'Connell et al, 2010;Robra and Thirumalai, 2016]. In amniotes, a remarkable population of DARPP-32-ir cells was also observed in the deep tectal layers of reptiles [Smeets et al, 2001[Smeets et al, , 2003], but in superficial tectal layers of birds [Araki et al, 2000;Absil et al, 2001;Metzger et al, 2006].…”

Section: Mesencephalonmentioning

confidence: 85%

“…The specificity of the antisera was tested previously [Hemmings and Greengard, 1986] and it has been used in immunohistochemical studies in tetrapods [Ouimet et al, 1992;Schnabel et al, 1997;Reiner et al, 1998;Smeets et al, 2001Smeets et al, , 2003López et al, 2010;Moreno et al, 2010]. In addition, the immunohistochemical reaction was corroborated with controls in which either the primary antibody, secondary antibody, or the PAP complex was omitted.…”

Section: Darpp-32 Immunohistochemistrymentioning

confidence: 99%

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Immunohistochemical Localization of DARPP-32 in the Brain of Two Lungfishes: Further Assessment of Its Relationship with the Dopaminergic System

López

Morona²,

González³

2017

Brain Behav Evol

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The distribution of DARPP-32 (a phosphoprotein related to the dopamine D₁ receptor) has been widely used as a means to clarify the brain regions with dopaminoceptive cells, primarily in representative species of tetrapods. The relationship between dopaminergic and dopaminoceptive elements is frequently analyzed using the catecholamine marker tyrosine hydroxylase (TH). In the present study, by means of combined immunohistochemistry, we have analyzed these relationships in lungfishes, the only group of sarcopterygian fishes represented by 6 extant species that are the phylogenetically closest living relatives of tetrapods. We used the Australian lungfish Neoceratodus forsteri and the African lungfish Protopterus dolloi. The DARPP-32 antibody yields a distinct and consistent pattern of neuronal staining in brain areas that, in general, coincide with areas that are densely innervated by TH-immunoreactive fibers. The striatum, thalamus, optic tectum, and torus semicircularis contain intensely DARPP-32-immunoreactive cell bodies and fibers. Cells are also located in the olfactory bulbs, amygdaloid complex, lateral septum, pallidum, preoptic area, suprachiasmatic nucleus, tuberal hypothalamic region, rostral rhombencephalic reticular formation, superior raphe nucleus, octavolateral area, solitary tract nucleus, and spinal cord. Remarkably, DARPP-32-immunoreactive fibers originating in the striatum reach the region of the dopaminergic cells in the mesencephalic tegmentum and represent a well-established striatonigral pathway in lungfishes. Double immunolabeling reveals that DARPP-32 is present in neurons that most likely receive TH input, but it is absent from the catecholaminergic neurons themselves, with the only exception of a few cells in the suprachiasmatic nucleus of Neoceratodus and the solitary tract nucleus of Protopterus. In addition, some species differences exist in the localization of DARPP-32 cells in the pallium, lateral amygdala, thalamus, prethalamus, and octavolateral area. In general, the present study demonstrates that the distribution pattern of DARPP-32, and its relationship with TH, is largely comparable to those reported for tetrapods, highlighting a shared situation among all sarcopterygians.

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Section: Rhombencephalon and Upper Spinal Cordmentioning

confidence: 65%

Section: Spinal Cordmentioning

confidence: 67%

Section: Diencephalonmentioning

confidence: 80%

Section: Mesencephalonmentioning

confidence: 85%

Section: Darpp-32 Immunohistochemistrymentioning

confidence: 99%

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Immunohistochemical Localization of DARPP-32 in the Brain of Two Lungfishes: Further Assessment of Its Relationship with the Dopaminergic System

López

Morona²,

González³

2017

Brain Behav Evol

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The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

849

879

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All animals evaluate the salience of external stimuli and integrate them with internal physiological information into adaptive behavior. Natural and sexual selection impinge on these processes, yet our understanding of behavioral decision-making mechanisms and their evolution is still very limited. Insights from mammals indicate that two neural circuits are of crucial importance in this context: the social behavior network and the mesolimbic reward system. Here we review evidence from neurochemical, tract-tracing, developmental, and functional lesion/stimulation studies that delineates homology relationships for most of the nodes of these two circuits across the five major vertebrate lineages: mammals, birds, reptiles, amphibians, and teleost fish. We provide for the first time a comprehensive comparative analysis of the two neural circuits and conclude that they were already present in early vertebrates. We also propose that these circuits form a larger social decision-making (SDM) network that regulates adaptive behavior. Our synthesis thus provides an important foundation for understanding the evolution of the neural mechanisms underlying reward processing and behavioral regulation. J. Comp. Neurol. 519:3599-3639, 2011. INDEXING TERMS: social behavior; comparative neuroanatomy; amphibian; reptile; bird; teleost; reward system; social behavior network; limbic system; neural circuitsThroughout their lives, all animals constantly face situations that provide either challenges (e.g., aggression, predation) or opportunities (e.g., reproduction, foraging, habitat selection) (for a detailed review, see O'Connell and Hofmann, 2011). In all cases, environmental cues are processed by sensory systems into a meaningful biological signal while internal physiological cues (e.g., condition, maturity) and prior experience are integrated at the same time. This process usually results in behavioral actions that are adaptive, i.e., beneficial to the animal. To accomplish this, an animal's nervous system must evaluate the salience of a stimulus and elicit a context-appropriate behavioral response. Despite tremendous progress in understanding the ecology and evolution of social behavior (Lorenz, 1952;Tinbergen, 1963;Lehrman, 1965;von Frisch, 1967;Krebs and Davies, 1993;Stephens, 2008), it is less understood where in the brain these decisions (e.g., about mate choice or territory defense) are made and how these brain circuits have arisen over the course of vertebrate evolution.Recent research has begun to decipher the neural basis of social decision-making. In mammals in particular, the neural circuits that evaluate stimulus salience and/or regulate social behavior have been uncovered to some degree: the mesolimbic reward system and social behavior network (Fig. 1). It is becoming increasingly clear that the reward system (including but not limited to the midbrain dopaminergic system) is the neural circuit where the salience of an external stimulus is evaluated (Deco and Rolls, 2005;Wickens et al., 2007), as appetitive beh...

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Regional chemoarchitecture of the brain of lungfishes based on calbindin D‐28K and calretinin immunohistochemistry

Morona

López

Northcutt

et al. 2018

J of Comparative Neurology

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Lungfishes are the closest living relatives of land vertebrates, and their neuroanatomical organization is particularly relevant for deducing the neural traits that have been conserved, modified, or lost with the transition from fishes to land vertebrates. The immunohistochemical localization of calbindin (CB) and calretinin (CR) provides a powerful method for discerning segregated neuronal populations, fiber tracts, and neuropils and is here applied to the brains of Neoceratodus and Protopterus, representing the two extant orders of lungfishes. The results showed abundant cells containing these proteins in pallial and subpallial telencephalic regions, with particular distinct distribution in the basal ganglia, amygdaloid complex, and septum. Similarly, the distribution of CB and CR containing cells supports the division of the hypothalamus of lungfishes into neuromeric regions, as in tetrapods. The dense concentrations of CB and CR positive cells and fibers highlight the extent of the thalamus. As in other vertebrates, the optic tectum is characterized by numerous CB positive cells and fibers and smaller numbers of CR cells. The so-called cerebellar nucleus contains abundant CB and CR cells with long ascending axons, which raises the possibility that it could be homologized to the secondary gustatory nucleus of other vertebrates. The corpus of the cerebellum is devoid of CB and CR and cells positive for both proteins are found in the cerebellar auricles and the octavolateralis nuclei. Comparison with other vertebrates reveals that lungfishes share most of their features of calcium binding protein distribution with amphibians, particularly with salamanders.

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Immunohistochemical localization of DARPP-32 in the brain and spinal cord of anuran amphibians and its relation with the catecholaminergic system

Cited by 14 publications

References 69 publications

Immunohistochemical Localization of DARPP-32 in the Brain of Two Lungfishes: Further Assessment of Its Relationship with the Dopaminergic System

Immunohistochemical Localization of DARPP-32 in the Brain of Two Lungfishes: Further Assessment of Its Relationship with the Dopaminergic System

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

Regional chemoarchitecture of the brain of lungfishes based on calbindin D‐28K and calretinin immunohistochemistry

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