2022
DOI: 10.1590/1414-431x2022e12375
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Immunohistochemical expression of Drosha is reduced in eutopic and ectopic endometrium of women with adenomyosis

Abstract: The objective of this study was to evaluate the immunohistochemical expression of Dicer, Drosha, and Exportin-5 in the eutopic and ectopic endometrium of women with adenomyosis. Twenty-two paired ectopic and eutopic endometrium from women with adenomyosis and 10 eutopic endometrium samples from control women undergoing hysterectomy were included in the study. Paraffin-embedded tissue blocks were cut and stained for immunohistochemistry. The percentage of epithelial cells positively marked was identified digita… Show more

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“…Global repression of miRNAs increased transformation in human cancer cell lines and promoted prominent cell motility, favoring the establishment of tumors and metastases [ 58 ]. We recently reported decreased DROSHA protein levels in adenomyosis and suggested a possible relationship between its pathophysiology and endometrial cancer [ 60 ]. Interestingly, DROSHA may regulate cell cycle progression in human MSCs via a miRNA-independent mechanism, potentially by regulating rRNA processing [ 61 ].…”
Section: Discussionmentioning
confidence: 99%
“…Global repression of miRNAs increased transformation in human cancer cell lines and promoted prominent cell motility, favoring the establishment of tumors and metastases [ 58 ]. We recently reported decreased DROSHA protein levels in adenomyosis and suggested a possible relationship between its pathophysiology and endometrial cancer [ 60 ]. Interestingly, DROSHA may regulate cell cycle progression in human MSCs via a miRNA-independent mechanism, potentially by regulating rRNA processing [ 61 ].…”
Section: Discussionmentioning
confidence: 99%